You can find TWiV #387 at microbe.tv/twiv, or listen below.
On episode #322 of the science show This Week in Virology, the TWiVodes answer listener email about hantaviruses, antivirals, H1N1 vaccine and narcolepsy, credibility of peer review, Bourbon virus, influenza vaccine, careers in virology, and much more.
You can find TWiV #322 at www.microbe.tv/twiv.
Morbidity and Mortality Weekly Report summarizes a mumps outbreak that occurred in 2011 on a university campus in California:
On September 29, 2011, the California Department of Public Health (CDPH) confirmed by polymerase chain reaction (PCR) three cases of mumps among students recently evaluated at their university’s student health services with symptoms suggestive of mumps. An investigation by CDPH, student health services, and the local health department identified 29 mumps cases. The presumed source patient was an unvaccinated student with a history of recent travel to Western Europe, where mumps is circulating. The student had mumps symptoms >28 days before the onset of symptoms among the patients confirmed on September 29. Recognizing that at least two generations of transmission had occurred before public health authorities were alerted, measles, mumps, and rubella (MMR) vaccine was provided as a control measure. This outbreak demonstrates the potential value of requiring MMR vaccination (including documentation of immunization or other evidence of immunity) before college enrollment, heightened clinical awareness, and timely reporting of suspected mumps patients to public health authorities.
All 29 cases were epidemiologically linked to the university. One of the cases was the source patient’s roommate who had received two doses of MMR (measles, mumps, rubella) vaccine. Other outbreaks of mumps have occurred in populations in which many individuals had received 2 doses of MMR.
Data collected during previous mumps outbreaks on college campuses indicate that extended person-to-person contact, in combination with waning vaccine-induced immunity, might make colleges and universities high-risk settings for outbreaks, even when 2-dose MMR vaccination coverage is high
CDC suggests that all colleges and universities consider requiring documentation that students have received 2 doses of MMR vaccine before matriculation.
The mumps vaccine was licensed in the US in 1967, resulting in a significant decline in the number of cases. However outbreaks continue to occur, even in immunized populations, when the virus is introduced by overseas travelers. The vaccine is included in national health programs of only 62% of countries, and immunization rates have declined in many European countries, leading to outbreaks of measles and mumps.
On episode #183 of the science show This Week in Virology, Connor Bamford joins the TWiV team to discuss bats as hosts for major mammalian paramyxoviruses.
You can find TWiV #183 at www.microbe.tv/twiv.
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit
Vincent, Alan, and Rich review recent outbreaks of mumps in the UK, US, and Israel, protection of mice against 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 vaccines, and a virus-like particle vaccine for chikungunya virus.
This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S.
Win a free Drobo S! Contest rules here.
Click the arrow above to play, or right-click to download TWiV #69 (59 MB .mp3, 82 minutes)
Links for this episode:
- Mumps outbreak in Israel (ProMedMail and Eurosurveillance; thanks Lenn!) and Iowa
- Retraction of Wakefield vaccines- autism study
- Immunization with 1918-like and classical swine H1N1 influenza viruses protects against 2009 H1N1 strain
- Virus-like particle vaccine for chikungunya virus
- Image: antigenic differences in HA structures of 1918, Cal/09 and Bris/59/07 viruses
- Paul Ewald articles (thanks Atila!): one, two, and three, and a recent review of the hypothesis
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