latency

CRISPR-ing herpes simplex virus

by Gertrud U. Rey Herpes simplex viruses establish lifelong persistent infection in sensory neurons of infected individuals, a phenomenon called latency. Latent viral genomes are “dormant” but can sporadically reactivate and begin replicating in a phase called lytic replication, which is often accompanied by shedding of virus particles and the appearance of painful lesions. There …

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TWiV 550: Covering up the shiny parts

TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes. Click arrow to play Download TWiV 550 (64 MB .mp3, 105 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

TWiV 379: A mouse divided

On episode #379 of the science show This Week in Virology, Scott Tibbetts joins the TWiVirate to describe his work on the role of a herpesviral nocoding RNA in establishment of peripheral latency, and then we visit two last minute additions to the Zika virus literature. You can find TWiV #379 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV379.mp3″] Click …

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TWiV 378: Herpes plays DUBstep

On episode #378 of the science show This Week in Virology, Greg Smith joins the TWiVirate to reveal how his lab discovered a switch that controls herpesvirus neuroinvasion, and then we visit the week’s news about Zika virus. You can find TWiV #378 at microbe.tv/twiv, or you may listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV378.mp3″] Click arrow to play Download TWiV …

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