integration

Wasps do a gain-of-function experiment in caterpillars

Parasitic wasps (in the order Hymenoptera) inject their eggs into lepidopteran hosts, where the eggs go through their developmental stages. Along with the eggs, the wasps also deliver viruses carrying genes encoding proteins that inhibit caterpillar immune defenses. Some of these genes are permanently transferred to the lepidopteran host where they have assumed new defensive functions against other …

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Authenticity of XMRV integration sites

Integration of retroviral DNA into the cellular genome is essential for the production of new infectious particles. A strong argument that the novel human retrovirus XMRV is not a laboratory contaminant is the finding that viral DNA is integrated in chromosomal DNA of prostate tumors. Nucleotide sequence analyses of 14 integration sites in prostate tumor DNAs …

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Retroviral integration and the XMRV provirus

A strong argument that the novel human retrovirus XMRV is not a laboratory contaminant is the finding that viral DNA is integrated in chromosomal DNA of prostate tumors. Why does this result constitute such strong proof of viral infection? Establishment of an integrated copy of the viral genome – the provirus – is a critical …

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TWiV 91: You’re an ERVous wreck

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson On episode #91 of the podcast This Week in Virology, Vincent, Dickson, Alan, Rich and Welkin discuss the nature, origin, and evolution of endogenous retroviruses (ERVs), and the recent finding of endogenous filovirus genomes in mammals. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV091.mp3″] Click the arrow above to play, …

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