immunosuppression

Fatal yellow fever in a transplant recipient

Infection with yellow fever virus caused the death of a patient 25 years after receiving a kidney transplant, illustrating the difficulties associated with some medical vaccine exemptions. The patient had received a kidney transplant at the age of 58 in February 1993. Nearly 25 years later he was admitted to hospital with two days of …

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Polyomavirus JC, multiple sclerosis, Tysabri, and an anti-malaria drug

Biogen has announced that an anti-malaria compound may be useful for treating a brain infection, progressive multifocal leukoencephalopathy (PML), that is an adverse effect of the company’s multiple sclerosis/Crohn’s disease drug Tysabri. How does JC virus fit into this story? Tysabri is the trade name for Natalizumab, a monoclonal antibody against the cellular protein alpha-4 integrin. …

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