HIV-1

TWiV 510: Retroviruses at Cold Spring Harbor

3 Comments / This Week in Virology / By

Vincent and Dickson travel to the 44th Retrovirus meeting at Cold Spring Harbor Laboratories, where they speak with John Coffin, Stephen Hughes, Ya-Chi Ho, and Matt Takata about the meeting and their work on HIV-1. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” …

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TWiV 465: Theodora the explorer

1 Comment / This Week in Virology / By

Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA. Click arrow to play Download TWiV 465 (53 MB .mp3, 88 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

Interview with Thomas Hope

Basic virology, Information / By

For the chapter on The Infectious Cycle in the textbook Principles of Virology, Vincent spoke with Thomas Hope, PhD, of Northwestern University Feinberg School of Medicine, about his career and his work on using high resolution microscopy to study the cell biology of infection with HIV-1.

A huge host contribution to virus mutation rates

3 Comments / Basic virology, Information / By

The high mutation rate of RNA viruses enables them to evolve in the face of different selection pressures, such as entering a new host or countering host defenses. It has always been thought that the sources of such mutations are the enzymes that copy viral RNA genomes: they make random errors which they cannot correct. Now …

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