TWiV 335: Ebola lite

On episode #335 of the science show This Week in Virology, the TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants.

You can find TWiV #335 at

NIH grant success rate hits all time low

Informative and sobering blog post from Sally Rockey, NIH Deputy Director for Extramural Research, on 2011 grant application success rates. It’s all summarized in this graph, taken from the NIH Data Book:

Research Project Grants 2011

The success rate, which is the number of funded grants divided by the number of applications, has dropped from a high point of just over 30% in the 1990s to a new low in 2011 of 18%. According to Rockey,

A number of factors contributed to the lower RPG success rates in 2011. One of the most obvious was an 8% increase in the number of competing RPG applications. We received a record 49,592 applications.

Jocelyn Kaiser has a good analysis of the data at ScienceInsider.

According to the data, 60% of all research project grants funded in 2011 were the investigator-initiated R01 grant, which has been the mainstay of basic science research at NIH. In my opinion, this number is too low. As you can see from the graph, the number of awards made has been declining since 2003. The US needs to invest more money in allowing investigators to explore – that  has historically been the proven way to generate innovative results which have the greatest impact on our health.