TWiV 457: The Red Queen meets the White Rabbit

Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population.

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TWiV 110: CSI virology

Alan DoveHosts: Vincent Racaniello, Dickson DespommierAlan Dove, and Rich Condit

On episode #110 of the podcast This Week in Virology, Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, the passing of Frank Fenner, polio outbreak in The Congo, solving criminal cases of HIV transmission, and classifying viruses by capsid structure.

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Weekly Science Picks

Dickson – CDC’s West Nile virus case count for 2010
Rich –
The red bees of Red Hook
Alan – Arsenic-based life at XKCD
Vincent –
PLoS iPad app

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Frank Fenner, MD, 1914-2010

Australian virologist Frank Fenner, MD was born in Ballarat, Victoria in 1914. He earned a Doctor of Medicine in 1942 at the University of Adelaide, and from 1940 – 1946 he worked on the malaria parasite in Egypt and Papua New Guinea as an officer in the Australian Army Medical Corps. He subsequently began studying the pathogenesis of mousepox virus at the Walter and Eliza Hall Institute of Medical Research in Melbourne. Later he was appointed Professor of Microbiology at the John Curtin School of Medical Research at the Australian National University, where he continued his work on viruses, including myxoma virus. His interest in the balance between virus virulence and host resistance was put to practical use in an effort to control Australia’s rabbit plague through the introduction of myxoma virus.

Dr. Fenner was a co-author of The Biology of Animal Viruses, first published in 1968. I still have my paperback ‘student’s edition’ which served as my virology bible during my years as a Ph.D. student. Later, when I was developing virology lectures for medical and graduate students, I relied on this book heavily. From the introduction:

During the last twenty years virology has developed into an independent science. It is now growing so rapidly that two new journals of virology were launched this year. Four major works on viruses of vertebrate animals have been published recently….However, none of these books deals in a comprehensive way with the broader biological principles of animal virology, which is the aim of this two-volume work.

The idea of presenting virology as a series of principles, not simply a list of viruses, was novel, and inspired us during the writing of Principles of Virology many years later.

Fenner’s classic studies on mousepox pathogenesis were the first to demonstrate how disseminated viral infections develop from local multiplication to primary and secondary viremia. In the case of mousepox, after local multiplication in the foot, the host response leads to swelling at the site of inoculation; after viremia, the host response to replication in the skin results in a rash. The figure at left depicting these events is included in Principles of Virology, because the findings serve as a paradigm for many other viral infections.

Fenner was also well known for his work on rabbitpox. European rabbits were introduced into Australia for hunting in 1859, and lacking natural predators, they reproduced to plague proportions. The rabbitpoxvirus, myxoma virus, was released in Australia in the 1950s in an attempt to rid the continent of these rabbits. In the first year, the infection killed the rabbits with a 99.8% mortality rate. By the second year the mortality dropped to 25%, and subsequently the rate of killing was lower than the reproductive rate of the rabbits, ending any hope for 100% eradication of the animals. The most important lesson from this incident is that the original idea to eliminate rabbits with a lethal virus was flawed, because powerful selective forces that could not be controlled or anticipated were at work. Fenner published a series of journal articles from 1950-1964 which carefully documented the changes in the virus and the host that occurred during this incident.

For more information on Dr. Fenner, see his interview from June of 2010 in The Australian, and a summary of his career at the Australian National University.

Fenner F (2010). Deliberate introduction of the European rabbit, Oryctolagus cuniculus, into Australia. Revue scientifique et technique (International Office of Epizootics), 29 (1), 103-11 PMID: 20617651

FENNER F, & WOODROOFE GM (1965). CHANGES IN THE VIRULENCE AND ANTIGENIC STRUCTURE OF STRAINS OF MYOMA VIRUS RECOVERED FROM AUSTRALIAN WILD RABBITS BETWEEN 1950 AND 1964. The Australian journal of experimental biology and medical science, 43, 359-70 PMID: 14343496