virology blog http://www.virology.ws About viruses and viral disease Thu, 02 Feb 2012 15:07:36 +0000 en hourly 1 http://wordpress.org/?v=3.3.1 About viruses and viral disease virology blog no virology blog vracaniello@gmail.com vracaniello@gmail.com (virology blog) About viruses and viral disease virology blog http://www.virology.ws/wp-content/plugins/powerpress/rss_default.jpg http://www.virology.ws TWiV 125 – TWiV infects FiB http://www.virology.ws/2011/03/20/twiv-125-twiv-infects-fib/ http://www.virology.ws/2011/03/20/twiv-125-twiv-infects-fib/#comments Sun, 20 Mar 2011 15:55:46 +0000 Vincent Racaniello http://www.virology.ws/?p=4018

icosahedron light

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Marc Pelletier

This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, and unintended spread of a recombinant retrovirus.

Click the arrow above to play, or right-click to download TWiV #125 (59 MB .mp3, 81 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Weekly Science Picks

Marc – JotNot
Dickson – New bunyavirus in China (NEJM)
Rich – Listening to the Deep Ocean Environment (LIDO) recording of the Hatsushima earthquake (ScienceDaily article) – thanks Bridget!
Alan -Walter and Ina: A Story of Love, War, and Science
Vincent – Icosahedral light fixture (thanks, Eric!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/03/20/twiv-125-twiv-infects-fib/feed/ 4 cafeteria virus,contamination,futures in biotech,giant virus,Marc Pelletier,mariner,retrovirus,sputnik,transposon,twit,viral,virology Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Marc Pelletier This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Marc Pelletier This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, and unintended spread of a recombinant retrovirus. Click the arrow above to play, or right-click to download TWiV #125 (59 MB .mp3, 81 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: A virophage at the origin of large DNA transposons (Science) EurekAlert! on virophage Sputnik, the first virophage (Nature) Unintended spread of BSL2 recombinant retrovirus (Retrovirology) TWiV on Facebook Letters read on TWiV 125 Video of this episode - download large or small .mp4 or view below Weekly Science Picks Marc - JotNot Dickson - New bunyavirus in China (NEJM) Rich - Listening to the Deep Ocean Environment (LIDO) recording of the Hatsushima earthquake (ScienceDaily article) - thanks Bridget! Alan -Walter and Ina: A Story of Love, War, and Science Vincent - Icosahedral light fixture (thanks, Eric!) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no Futures in Biotech 76: It’s time to proteo me http://www.virology.ws/2011/03/16/futures-in-biotech-76-its-time-to-proteo-me/ http://www.virology.ws/2011/03/16/futures-in-biotech-76-its-time-to-proteo-me/#comments Wed, 16 Mar 2011 20:32:19 +0000 Vincent Racaniello http://www.virology.ws/?p=3984

I joined Marc Pelletier and Ruedi Aebersold on futures-in-biotechepisode 76 of Futures in Biotech for a conversation about how mass spectrometry has become one of the most important technologies in our move towards personalized medicine. We also talk about systems biology, a topic we first discussed in TWiV #121.

Click the arrow above to play, or right-click to download FiB #76 (33 MB .mp3, 68 minutes)

Download video (292 MB .mp4)

]]> http://www.virology.ws/2011/03/16/futures-in-biotech-76-its-time-to-proteo-me/feed/ 1 futures in biotech,Marc Pelletier,proteome,proteomics,ruedi aebersold,systems biology,viral,virology,virus I joined Marc Pelletier and Ruedi Aebersold on episode 76 of Futures in Biotech for a conversation about how mass spectrometry has become one of the most important technologies in our move towards personalized medicine. I joined Marc Pelletier and Ruedi Aebersold on episode 76 of Futures in Biotech for a conversation about how mass spectrometry has become one of the most important technologies in our move towards personalized medicine. We also talk about systems biology, a topic we first discussed in TWiV #121. Click the arrow above to play, or right-click to download FiB #76 (33 MB .mp3, 68 minutes) Download video (292 MB .mp4) virology blog no TWiV 124: Viruses that make you better http://www.virology.ws/2011/03/13/twiv-124-viruses-that-make-you-better/ http://www.virology.ws/2011/03/13/twiv-124-viruses-that-make-you-better/#comments Sun, 13 Mar 2011 12:45:48 +0000 Vincent Racaniello http://www.virology.ws/?p=3994

Rabbits Myxomatosis Trial WardangIsland 1938Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Grant McFadden

On episode #124 of the podcast This Week in Virology, Vincent, Dickson, Alan, Rich, and Grant discuss a tanapoxvirus protein that inhibits tumor necrosis factor, purging tumors with myxoma virus, and destruction of the last known stocks of smallpox virus.

Click the arrow above to play, or right-click to download TWiV #124 (74 MB .mp3, 103 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Weekly Science Picks

Grant – A Short History of Nearly Everything by Bill Bryson
Dickson – An Inquiry into the Causes and Effects of the Variolae Vaccinae by Edward Jenner
Rich – Selinah (Topsy Foundation) thanks Meghan!
Alan – Draft report (pdf) on WHO’s H1N1 response and NY Times summary
Vincent – 10 stunning science visualizations

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/03/13/twiv-124-viruses-that-make-you-better/feed/ 0 bioterrorism,cancer therapy,myxoma virus,oncolysis,oncolytic,poxvirus,smallpox,tanapox virus,tumor,viral,virology,virus Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Grant McFadden On episode #124 of the podcast This Week in Virology, Vincent, Dickson, Alan, Rich, and Grant discuss a tanapoxvirus protein that inhibits tumor necrosis fact... Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Grant McFadden On episode #124 of the podcast This Week in Virology, Vincent, Dickson, Alan, Rich, and Grant discuss a tanapoxvirus protein that inhibits tumor necrosis factor, purging tumors with myxoma virus, and destruction of the last known stocks of smallpox virus. Click the arrow above to play, or right-click to download TWiV #124 (74 MB .mp3, 103 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Interaction of tumor necrosis factor with tanapox virus protein Viron Therapeutics Inc Oncolytic viral purging with myxoma virus Why not destroy remaining smallpox stocks? (editorial) US should agree to destroy smallpox stocks (CIDRAP) TWiV on Facebook Letters read on TWiV 124 Weekly Science Picks Grant - A Short History of Nearly Everything by Bill Bryson Dickson - An Inquiry into the Causes and Effects of the Variolae Vaccinae by Edward Jenner Rich - Selinah (Topsy Foundation) thanks Meghan! Alan - Draft report (pdf) on WHO's H1N1 response and NY Times summary Vincent - 10 stunning science visualizations Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiM #2 – The plague, microbial virulence, and the gut microbiome http://www.virology.ws/2011/03/09/twim-2-the-plague-microbial-virulence-and-the-gut-microbiome/ http://www.virology.ws/2011/03/09/twim-2-the-plague-microbial-virulence-and-the-gut-microbiome/#comments Thu, 10 Mar 2011 01:34:16 +0000 Vincent Racaniello http://www.virology.ws/?p=3988

gut microbiomeOn episode #2 of This Week in Microbiology, Vincent, Cliff, and Michael review a fatal laboratory acquired Yersinia pestis infection, and how gut bacteria control body weight and metabolic activity..

Click the arrow above to play, or right-click to download TWiM #2 (52 MB .mp3, 75 minutes).

Subscribe to TWiM (free) at iTunes, the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld App.

Links for this episode:

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv or leave voicemail at 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

]]> http://www.virology.ws/2011/03/09/twim-2-the-plague-microbial-virulence-and-the-gut-microbiome/feed/ 2 bacteria,bacteriology,gut microbiome,microbiology,plague,prokaryote,yersinia On episode #2 of This Week in Microbiology, Vincent, Cliff, and Michael review a fatal laboratory acquired Yersinia pestis infection, and how gut bacteria control body weight and metabolic activity.. - Click the arrow above to play, On episode #2 of This Week in Microbiology, Vincent, Cliff, and Michael review a fatal laboratory acquired Yersinia pestis infection, and how gut bacteria control body weight and metabolic activity.. Click the arrow above to play, or right-click to download TWiM #2 (52 MB .mp3, 75 minutes). Subscribe to TWiM (free) at iTunes, the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld App. Links for this episode: Fatal laboratory acquired Yersinia infection (thanks, Alan!) Hemochromatosis Gut bacteria can control metabolic functions (mBio) Systems biology approach to infectious disease research (mBio) Dr. B. Brett Finlay's 3D animations Letters read on TWiM #2 Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv or leave voicemail at 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim. virology blog no TWiV 123: Contaminated prostates, absolute truth, and bleached worms http://www.virology.ws/2011/03/06/twiv-123-contaminated-prostates-absolute-truth-and-bleached-worms/ http://www.virology.ws/2011/03/06/twiv-123-contaminated-prostates-absolute-truth-and-bleached-worms/#comments Sun, 06 Mar 2011 19:12:02 +0000 Vincent Racaniello http://www.virology.ws/?p=3973

42Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

On episode #123 of the podcast This Week in Virology, Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, and the first virus of Caenorhabditis nematodes.

Click the arrow above to play, or right-click to download TWiV #123 (67 MB .mp3, 93 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Weekly Science Picks

Rich – Einstein: His Life and Universe by Walter Isaacson (Aspen Institute)
Alan – Hi-definition microscopy movies in 3D
Vincent – Stan Maloy interview with Beatrice Hahn on the origins of HIV and malaria

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/03/06/twiv-123-contaminated-prostates-absolute-truth-and-bleached-worms/feed/ 51 caenorhabditis elegans,chronic fatigue syndrome,integration site,mecfs,nematode,prostate cancer,provirus,retrovirus,scientific method,viral,virology,virus Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #123 of the podcast This Week in Virology, Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #123 of the podcast This Week in Virology, Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, and the first virus of Caenorhabditis nematodes. Click the arrow above to play, or right-click to download TWiV #123 (67 MB .mp3, 93 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Analysis of XMRV integration sites from human prostate cancer (Retrovirology) Integration site preference of XMRV (J Virology) The Decline Effect and the Scientific Method by Jonathan Lehrer (New Yorker) Why most published research findings are false (PLoS Medicine) Cochrane Reviews Richard Feynman's 1974 Caltech Commencement Address (pdf) (thanks, Bill!) First virus of Caenorhabditis (PLoS Biology) Nodaviruses at ViralZone Spandrels (thanks, Welkin!) TWiV on Facebook Letters read on TWiV 123 Weekly Science Picks Rich - Einstein: His Life and Universe by Walter Isaacson (Aspen Institute) Alan - Hi-definition microscopy movies in 3D Vincent - Stan Maloy interview with Beatrice Hahn on the origins of HIV and malaria Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiP 23: Strongyloides stercoralis, a most unusual parasite http://www.virology.ws/2011/03/03/twip-23-strongyloides-stercoralis-a-most-unusual-parasite/ http://www.virology.ws/2011/03/03/twip-23-strongyloides-stercoralis-a-most-unusual-parasite/#comments Thu, 03 Mar 2011 22:21:40 +0000 Vincent Racaniello http://www.virology.ws/?p=3967

strongyloides stercoralis freelivingHosts: Vincent Racaniello and Dickson Despommier

On episode 23 of the podcast This Week in Parasitism, Vincent and Dickson review the life cycle and pathogenesis of the world’s most unusual parasite, Strongyloides stercoralis.

Click the arrow above to play, or right-click to download TWiP #23 (74 MB .mp3, 103 minutes)

TWiP is brought to you by the American Society for Microbiology at Microbeworld.org.

Links for this episode:

Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email

Send your questions and comments to twip@twiv.tv

]]> http://www.virology.ws/2011/03/03/twip-23-strongyloides-stercoralis-a-most-unusual-parasite/feed/ 4 filaria,nematode,parasite,parasitism,strongyloides stercoralis Hosts: Vincent Racaniello and Dickson Despommier On episode 23 of the podcast This Week in Parasitism, Vincent and Dickson review the life cycle and pathogenesis of the world's most unusual parasite, Strongyloides stercoralis. - Hosts: Vincent Racaniello and Dickson Despommier On episode 23 of the podcast This Week in Parasitism, Vincent and Dickson review the life cycle and pathogenesis of the world's most unusual parasite, Strongyloides stercoralis. Click the arrow above to play, or right-click to download TWiP #23 (74 MB .mp3, 103 minutes) TWiP is brought to you by the American Society for Microbiology at Microbeworld.org. Links for this episode: Free-living Strongyloides stercoralis adult (jpg) Small intestine with numerous sections of female S. stercoralis (jpg) Rhabditiform larva of S. sterocoralis (jpg) Filariform larva of S. stercoralis in skin (jpg) S. stercoralis buccal cavity (jpg) S. stercoralis life cycle (jpg) Letters read on TWiP 23 Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email Send your questions and comments to twip@twiv.tv virology blog no TWiV 122: More fun than a monkey full of viruses http://www.virology.ws/2011/02/27/twiv-122-more-fun-than-a-monkey-full-of-viruses/ http://www.virology.ws/2011/02/27/twiv-122-more-fun-than-a-monkey-full-of-viruses/#comments Sun, 27 Feb 2011 15:35:09 +0000 Vincent Racaniello http://www.virology.ws/?p=3950

japanese macaquesHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson

On episode #122 of the podcast This Week in Virology, the complete TWiV crew teams up with Welkin Johnson to explore the other AIDS epidemic, infection of monkeys with simian immunodeficiency virus, and its restriction by the cellular protein TRIM5.

Click the arrow above to play, or right-click to download TWiV #122 (77 MB .mp3, 147 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Weekly Science Picks

Welkin – Supramap
Dickson – Science issue on visualizing data
Rich – Doonesbury weighs in on vaccines and autism
Alan – US National Vaccine Plan
Vincent – US Supreme Court decision on vaccine litigation (NY Times)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/02/27/twiv-122-more-fun-than-a-monkey-full-of-viruses/feed/ 0 AIDS,endogenous retrovirus,ERV,macaque,old world monkey,retroviral restriction,simian immunodeficiency virus,siv,trim5,viral,virology,virus Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson On episode #122 of the podcast This Week in Virology, the complete TWiV crew teams up with Welkin Johnson to explore the other AIDS epidemic, Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson On episode #122 of the podcast This Week in Virology, the complete TWiV crew teams up with Welkin Johnson to explore the other AIDS epidemic, infection of monkeys with simian immunodeficiency virus, and its restriction by the cellular protein TRIM5. Click the arrow above to play, or right-click to download TWiV #122 (77 MB .mp3, 147 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Edwin Kilbourne, MD, 1920-2011 Evolution of TRIM5-CypA in Old World monkeys (PLoS Pathogens) Balancing selection and evolution of Old World TRIM5 (PNAS) TRIM5 and cross-species transmission of a primate retrovirus (PLoS Biology) Infectious retrovirus in pet vaccines (J Virology) TWiV on Facebook Letters read on TWiV 122 Weekly Science Picks Welkin - Supramap Dickson - Science issue on visualizing data Rich - Doonesbury weighs in on vaccines and autism Alan - US National Vaccine Plan Vincent - US Supreme Court decision on vaccine litigation (NY Times) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no This Week in Microbiology http://www.virology.ws/2011/02/23/this-week-in-microbiology/ http://www.virology.ws/2011/02/23/this-week-in-microbiology/#comments Wed, 23 Feb 2011 20:16:10 +0000 Vincent Racaniello http://www.virology.ws/?p=3919

This Week in MicrobiologyHosts: Vincent Racaniello, Cliff Mintz, Michael Schmidt, and Stanley Maloy

I’m pleased to announce the launch today of This Week in Microbiology, a podcast that explores unseen life on Earth. As with our other podcasts This Week in Virology (TWiV) and This Week in Parasitism (TWiP), we will strive to produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.

As a science Professor at Columbia University, I have spent my academic career directing a research laboratory focused on viruses. My enthusiasm for teaching inspired me to reach beyond the classroom using new media. TWiM is for everyone who wants to learn about the science of microbiology in a casual way.

While there are no exams or pop quizzes, TWiM does encourage interaction with the audience via comments on specific episodes (see below) and email. Listeners can also use MicrobeWorld to suggest topics for the show by submitting articles or papers to the site and tagging them with twim.

On episode #1 of This Week in Microbiology, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact.

Download TWiM #1 (58 MB .mp3, 63 minutes). To download, right-click or control-click on the link, then select save as.

Subscribe to TWiM (free) at iTunes, the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld App.

Links for this episode:

Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv or leave voicemail at 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.

]]> http://www.virology.ws/2011/02/23/this-week-in-microbiology/feed/ 5 antimicrobial,copper,microbiology,neisseria gonorrhoeae,twim Hosts: Vincent Racaniello, Cliff Mintz, Michael Schmidt, and Stanley Maloy I'm pleased to announce the launch today of This Week in Microbiology, a podcast that explores unseen life on Earth. As with our other podcasts This Week in Virology (TWiV) and... Hosts: Vincent Racaniello, Cliff Mintz, Michael Schmidt, and Stanley Maloy I'm pleased to announce the launch today of This Week in Microbiology, a podcast that explores unseen life on Earth. As with our other podcasts This Week in Virology (TWiV) and This Week in Parasitism (TWiP), we will strive to produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background. As a science Professor at Columbia University, I have spent my academic career directing a research laboratory focused on viruses. My enthusiasm for teaching inspired me to reach beyond the classroom using new media. TWiM is for everyone who wants to learn about the science of microbiology in a casual way. While there are no exams or pop quizzes, TWiM does encourage interaction with the audience via comments on specific episodes (see below) and email. Listeners can also use MicrobeWorld to suggest topics for the show by submitting articles or papers to the site and tagging them with twim. On episode #1 of This Week in Microbiology, Vincent, Cliff, Michael, and Stan discuss transfer of DNA from a human host to a bacterial pathogen, and the ability of dry copper to kill bacteria on contact. Download TWiM #1 (58 MB .mp3, 63 minutes). To download, right-click or control-click on the link, then select save as. Subscribe to TWiM (free) at iTunes, the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld App. Links for this episode: Horizontal gene transfer from a human host to a bacterial pathogen LINE = Long INterspersed Element Human DNA in Bacterial Genomes? Dry copper kills bacteria on contact Microbe by Elio Schaecter Small Things Considered - Microbiology blog Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv or leave voicemail at 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim. virology blog no TWiV 121: Huskies go viral http://www.virology.ws/2011/02/20/twiv-121-huskies-go-viral/ http://www.virology.ws/2011/02/20/twiv-121-huskies-go-viral/#comments Sun, 20 Feb 2011 23:23:10 +0000 Vincent Racaniello http://www.virology.ws/?p=3907

viral huskiesHosts: Vincent Racaniello, Michael Katze, Michael Gale, Deborah Fuller, and Shawn Iadonato

Episode #121 of the podcast This Week in Virology is a conversation about careers in virology, systems biology, innate immunity, and antiviral research recorded at the University of Washington in Seattle.

Click the arrow above to play, or right-click to download TWiV #121 (65 MB .mp3, 90 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:


Weekly Science Picks

Michael K – Pasteur Museum
Deborah – Undaunted Courage by Stephen Ambros
Michael G – The Eighth Day of Creation by Horace Freeland Judson
Vincent – The Emperor of All Maladies by Siddhartha Mukherjee

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/02/20/twiv-121-huskies-go-viral/feed/ 0 antiviral,hepatitis C virus,influenza,innate immunity,interferon,systems biology,viral,virology,virus Hosts: Vincent Racaniello, Michael Katze, Michael Gale, Deborah Fuller, and Shawn Iadonato Episode #121 of the podcast This Week in Virology is a conversation about careers in virology, systems biology, innate immunity, Hosts: Vincent Racaniello, Michael Katze, Michael Gale, Deborah Fuller, and Shawn Iadonato Episode #121 of the podcast This Week in Virology is a conversation about careers in virology, systems biology, innate immunity, and antiviral research recorded at the University of Washington in Seattle. Click the arrow above to play, or right-click to download TWiV #121 (65 MB .mp3, 90 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app. Links for this episode: A systems biology approach to infectious disease research (mBio) Infectious Curiosity (thanks, Gopal!) Astronomy Cast (thanks, Jacob!) The Journal of Negative Results (thanks, Patricia!) Scientist Solutions (thanks, Patricia!) Bacteriophage as antibacterial solution (thanks, Peter!) TWiV on Facebook Letters read on TWiV 121 Video of this episode -  view below or download .mp4 (1 GB) Weekly Science Picks Michael K - Pasteur Museum Deborah - Undaunted Courage by Stephen Ambros Michael G - The Eighth Day of Creation by Horace Freeland Judson Vincent - The Emperor of All Maladies by Siddhartha Mukherjee Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 120: Ed Niles, a Km Vmax kind of guy http://www.virology.ws/2011/02/13/twiv-120-ed-niles-a-km-vmax-kind-of-guy/ http://www.virology.ws/2011/02/13/twiv-120-ed-niles-a-km-vmax-kind-of-guy/#comments Sun, 13 Feb 2011 13:39:52 +0000 Vincent Racaniello http://www.virology.ws/?p=3891

BARDAHosts: Vincent Racaniello, Rich Condit, and Ed Niles

On episode #120 of the podcast This Week in Virology, Vincent, Rich, and Ed discuss the transition from academic scientist to government work, the general program of drug and vaccine development in the biodefense world and at BARDA, and career opportunities for scientists in government.

Click the arrow above to play, or right-click to download TWiV #120 (77 MB .mp3, 147 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Weekly Science Picks

Rich – Dark Sun: The Making of the Hydrogen Bomb by Richard Rhodes
Ed – Tenth anniversary of the human genome at Science Magazine
Vincent – Poliovirus fights back

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/02/13/twiv-120-ed-niles-a-km-vmax-kind-of-guy/feed/ 2 acam2000,bacteriophage t7,barda,ed niles,imvamune,poxvirus,smallpox,vaccine,viral,virology,virus Hosts: Vincent Racaniello, Rich Condit, and Ed Niles On episode #120 of the podcast This Week in Virology, Vincent, Rich, and Ed discuss the transition from academic scientist to government work, the general program of drug and vaccine development i... Hosts: Vincent Racaniello, Rich Condit, and Ed Niles On episode #120 of the podcast This Week in Virology, Vincent, Rich, and Ed discuss the transition from academic scientist to government work, the general program of drug and vaccine development in the biodefense world and at BARDA, and career opportunities for scientists in government. Click the arrow above to play, or right-click to download TWiV #120 (77 MB .mp3, 147 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app. Links for this episode: ACAM2000 smallpox vaccine Bavarian Nordic's smallpox vaccine Imvamune and phase II trial Rich and Ed's paper on bacteriophage T7 mRNAs Quandaries of dengue vaccine development Tetravalent dengue vaccine VIVA - virology at Vassar TWiV on Facebook Letters read on TWiV 120 Weekly Science Picks Rich - Dark Sun: The Making of the Hydrogen Bomb by Richard Rhodes Ed - Tenth anniversary of the human genome at Science Magazine Vincent - Poliovirus fights back Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiP 22: Hookworm http://www.virology.ws/2011/02/09/twip-22-hookworm/ http://www.virology.ws/2011/02/09/twip-22-hookworm/#comments Wed, 09 Feb 2011 15:03:11 +0000 Vincent Racaniello http://www.virology.ws/?p=3869

hookwormHosts: Vincent Racaniello and Dickson Despommier

On episode 22 of the podcast This Week in Parasitism, Vincent and Dickson discuss possibly the most socially and politically important nematode of humans, the hookworm Ancylostoma duodenale and Necator americanus.

Click the arrow above to play, or right-click to download

TWiP is brought to you by the American Society for Microbiology at Microbeworld.org.

Links for this episode:

Download TWiP #22 (70 MB .mp3, 97 minutes)

Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email

Send your questions and comments to twip@twiv.tv

]]> http://www.virology.ws/2011/02/09/twip-22-hookworm/feed/ 3 ancylostoma duodenale,hookworm,necator americanus,parasite,parasitism Hosts: Vincent Racaniello and Dickson Despommier On episode 22 of the podcast This Week in Parasitism, Vincent and Dickson discuss possibly the most socially and politically important nematode of humans, the hookworm Ancylostoma duodenale and Necato... Hosts: Vincent Racaniello and Dickson Despommier On episode 22 of the podcast This Week in Parasitism, Vincent and Dickson discuss possibly the most socially and politically important nematode of humans, the hookworm Ancylostoma duodenale and Necator americanus. Click the arrow above to play, or right-click to download TWiP is brought to you by the American Society for Microbiology at Microbeworld.org. Links for this episode: Diagrams of adult hookworm (jpg) Ancylostoma duodenale adults (jpg) Hookworm mouth (jpg) Hookworm eggs (jpg) Hookworm life cycle (jpg) Letters read on TWiP 22 Download TWiP #22 (70 MB .mp3, 97 minutes) Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email Send your questions and comments to twip@twiv.tv virology blog no TWiV 119: Science and journalism with David Tuller http://www.virology.ws/2011/02/06/twiv-119-science-and-journalism-with-david-tuller/ http://www.virology.ws/2011/02/06/twiv-119-science-and-journalism-with-david-tuller/#comments Sun, 06 Feb 2011 18:38:05 +0000 Vincent Racaniello http://www.virology.ws/?p=3865

science journalismHosts: Vincent Racaniello and David Tuller

On episode #119 of the podcast This Week in Virology, Vincent and journalist David Tuller converse about the state of science reporting by the press.

Click the arrow above to play, or right-click to download TWiV #119 (43 MB .mp3, 60 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/02/06/twiv-119-science-and-journalism-with-david-tuller/feed/ 30 AIDS,chronic fatigue syndrome,david tuller,HIV,journalism,mecfs,science press,science reporting,viral,virology,virus Hosts: Vincent Racaniello and David Tuller On episode #119 of the podcast This Week in Virology, Vincent and journalist David Tuller converse about the state of science reporting by the press. - Click the arrow above to play, Hosts: Vincent Racaniello and David Tuller On episode #119 of the podcast This Week in Virology, Vincent and journalist David Tuller converse about the state of science reporting by the press. Click the arrow above to play, or right-click to download TWiV #119 (43 MB .mp3, 60 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app. Links for this episode: The four XMRV papers in Retrovirology (one, two, three, four) and a commentary David's recent coverage of ME/CFS in the NY Times (July 2010, August 2010, January 2011) MRSA (methicillin-resistant Staphylococcus aureus): The press' mea culpa TWiV on Facebook Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 118: The virus always rings twice http://www.virology.ws/2011/01/30/twiv-118-the-virus-always-rings-twice/ http://www.virology.ws/2011/01/30/twiv-118-the-virus-always-rings-twice/#comments Sun, 30 Jan 2011 17:54:39 +0000 Vincent Racaniello http://www.virology.ws/?p=3844

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

On episode #118 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about vaccinia virus, fungal viruses, synthetic viruses, influenza vaccine, HeLa cells, multiplicity of infection, and much more.

Click the arrow above to play, or right-click to download TWiV #118 (68 MB .mp3, 94  minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

Weekly Science Picks

Alan – What you need to know about infectious disease
Rich – Bad Project (YouTube)
Vincent – Federal research center will help develop medicines

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/01/30/twiv-118-the-virus-always-rings-twice/feed/ 0 arsenic,entropy,fungal virus,HeLa cells,influenza vaccine,moi,synthetic virus,vaccinia,viral,virology,virus Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #118 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about vaccinia virus, fungal viruses, synthetic viruses, influenza vaccine, HeLa cells, Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #118 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about vaccinia virus, fungal viruses, synthetic viruses, influenza vaccine, HeLa cells, multiplicity of infection, and much more. Click the arrow above to play, or right-click to download TWiV #118 (68 MB .mp3, 94  minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with the Microbeworld app. Links for this episode: Distribution of glycoproteins on virion surface (paper 1, paper 2) - thanks, Conor! Susceptibility of cancer cell lines to tanapox (thanks, Cheryl!) Poxvirus family tree Sugar, the bitter truth (YouTube) - thanks, Mary! BBC podcast: Artificial life (thanks, Sam!) Arthritis and influenza at CDC Multiplicity of infection at virology blog Virus-like particle vaccines (thanks, Sheldon!) TWiV on Facebook Letters read on TWiV 118 Weekly Science Picks Alan - What you need to know about infectious disease Rich - Bad Project (YouTube) Vincent - Federal research center will help develop medicines Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 117: The Panic Virus with Seth Mnookin http://www.virology.ws/2011/01/23/twiv-117-the-panic-virus-with-seth-mnookin/ http://www.virology.ws/2011/01/23/twiv-117-the-panic-virus-with-seth-mnookin/#comments Sun, 23 Jan 2011 18:22:41 +0000 Vincent Racaniello http://www.virology.ws/?p=3834

panic virusHosts: Vincent Racaniello, Rich Condit, and Seth Mnookin

On episode #117 of the podcast This Week in Virology, Vincent and Rich converse with Seth Mnookin, author of The Panic Virus, about vaccines, autism, thimerosal, and a contagion of human unreason run wild.

Click the arrow above to play, or right-click to download TWiV #117 (69 MB .mp3, 96  minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Rich and Vincent – The Panic Virus by Seth Mnookin

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/01/23/twiv-117-the-panic-virus-with-seth-mnookin/feed/ 1 autism,mmr vaccine,panic virus,seth mnookin,thimerosal,viral,virology,virus Hosts: Vincent Racaniello, Rich Condit, and Seth Mnookin On episode #117 of the podcast This Week in Virology, Vincent and Rich converse with Seth Mnookin, author of The Panic Virus, about vaccines, autism, thimerosal, Hosts: Vincent Racaniello, Rich Condit, and Seth Mnookin On episode #117 of the podcast This Week in Virology, Vincent and Rich converse with Seth Mnookin, author of The Panic Virus, about vaccines, autism, thimerosal, and a contagion of human unreason run wild. Click the arrow above to play, or right-click to download TWiV #117 (69 MB .mp3, 96  minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Functional HERV-K envelope protein (thanks, Jamie!) Reverse zoonoses Dog influenza at CDC TWiV on Facebook Letters read on TWiV 117 Weekly Science Picks Rich and Vincent - The Panic Virus by Seth Mnookin Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiP 21: The giant intestinal worm, Ascaris lumbricoides http://www.virology.ws/2011/01/19/twip-21-the-giant-intestinal-worm-ascaris-lumbricoides/ http://www.virology.ws/2011/01/19/twip-21-the-giant-intestinal-worm-ascaris-lumbricoides/#comments Thu, 20 Jan 2011 03:37:17 +0000 Vincent Racaniello http://www.virology.ws/?p=3812

ascaris adultsHosts: Vincent Racaniello and Dickson Despommier

On episode 21 of the podcast This Week in Parasitism, Vincent and Dickson review the biology and pathogenesis of Ascaris lumbricoides, one of the largest nematodes to infect humans.

Click the arrow above to play, or right-click to download

TWiP is brought to you by the American Society for Microbiology at Microbeworld.org.

Links for this episode:

Download TWiP #21 (66 MB .mp3, 92 minutes)

Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email

Send your questions and comments to twip@twiv.tv

]]> http://www.virology.ws/2011/01/19/twip-21-the-giant-intestinal-worm-ascaris-lumbricoides/feed/ 3 ascaris,nematode,parasite,parasitism,podcast,roundworm,twip Hosts: Vincent Racaniello and Dickson Despommier On episode 21 of the podcast This Week in Parasitism, Vincent and Dickson review the biology and pathogenesis of Ascaris lumbricoides, one of the largest nematodes to infect humans. - Hosts: Vincent Racaniello and Dickson Despommier On episode 21 of the podcast This Week in Parasitism, Vincent and Dickson review the biology and pathogenesis of Ascaris lumbricoides, one of the largest nematodes to infect humans. Click the arrow above to play, or right-click to download TWiP is brought to you by the American Society for Microbiology at Microbeworld.org. Links for this episode: Ascaris lumbricoides adult female (top) and male (jpg) Ascaris lumbricoides life cycle (jpg) Child with distended abdomen due to Ascaris (jpg) Adult Ascaris removed from child in previous figure (jpg) Toxocara canis and Toxocara cati life cycle (jpg) Letters read on TWiP 21 Download TWiP #21 (66 MB .mp3, 92 minutes) Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email Send your questions and comments to twip@twiv.tv virology blog no TWiV 116: Cocaine, colonies, and chickens http://www.virology.ws/2011/01/16/twiv-116-cocaine-colonies-and-chickens/ http://www.virology.ws/2011/01/16/twiv-116-cocaine-colonies-and-chickens/#comments Sun, 16 Jan 2011 20:02:43 +0000 Vincent Racaniello http://www.virology.ws/?p=3810

hive and feeding bottlesHosts: Vincent Racaniello, Alan Dove, and Rich Condit

On episode #116 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, a field trial of RNAi to prevent Israeli acute paralysis virus infection in honeybees, and suppression of avian influenza transmission in transgenic chickens.

Click the arrow above to play, or right-click to download TWiV #116 (64 MB .mp3, 89 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Dickson – Brian Deer’s investigation of the Wakefield and MMR vaccine
Rich – Photographic periodic table of the elements
Alan – Year of the bat (site one and site two)
Vincent – EteRNA (NY Times article)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/01/16/twiv-116-cocaine-colonies-and-chickens/feed/ 3 addiction,adenovirus,avian flu,chicken,cocaine,colony collapse disorder,H5N1,honeybee,influenza,rnai,vaccine,viral Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #116 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #116 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich review an adenovirus-based vaccine strategy against drug addiction, a field trial of RNAi to prevent Israeli acute paralysis virus infection in honeybees, and suppression of avian influenza transmission in transgenic chickens. Click the arrow above to play, or right-click to download TWiV #116 (64 MB .mp3, 89 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Cocaine analog coupled to disrupted adenovirus Field application of RNAi in honeybees Suppression of avian influenza transmission in GM chickens (EurekAlert) Phage tailspike protein therapy Use of phage lysins to treat bacterial infections (one and two) Cell to cell spread of viruses (review and inhibition by tetherin) Flock house virus replication organelle (thanks Brett!) TWiV on Facebook Letters read on TWiV 116 Weekly Science Picks Dickson - Brian Deer's investigation of the Wakefield and MMR vaccine Rich - Photographic periodic table of the elements Alan - Year of the bat (site one and site two) Vincent - EteRNA (NY Times article) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 115: Color me infected http://www.virology.ws/2011/01/09/twiv-115-color-me-infected/ http://www.virology.ws/2011/01/09/twiv-115-color-me-infected/#comments Sun, 09 Jan 2011 21:46:16 +0000 Vincent Racaniello http://www.virology.ws/?p=3787

brainbow pseudorabies virusHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Marc Pelletier

On episode #115 of the podcast This Week in Virology, Vincent, Alan, Rich and Marc discuss the finding that a limited number of incoming herpesviral genomes can replicate and express in a cell, and controlling viral replication in Aedes aegypti with a Wolbachia symbiont.

Click the arrow above to play, or right-click to download TWiV #115 (84 MB .mp3, 117 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Marc – Homebrew bioreactor (photo, movie) – culture bottle and drive, oil-free vacuum pumps
Rich – Logitech Harmony Universal Remote
Alan – H.M.S. Challenger Reports
Vincent – Sequence of the strawberry genome and blog post by lead author

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/01/09/twiv-115-color-me-infected/feed/ 0 aedes aegypti,brainbow,Chikungunya,Dengue,herpesvirus,malaria,mosquito,plaque,pseudorabies virus,replication,viral,virology Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Marc Pelletier On episode #115 of the podcast This Week in Virology, Vincent, Alan, Rich and Marc discuss the finding that a limited number of incoming herpesviral genomes can replicate and exp... Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Marc Pelletier On episode #115 of the podcast This Week in Virology, Vincent, Alan, Rich and Marc discuss the finding that a limited number of incoming herpesviral genomes can replicate and express in a cell, and controlling viral replication in Aedes aegypti with a Wolbachia symbiont. Click the arrow above to play, or right-click to download TWiV #115 (84 MB .mp3, 117 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Replication and expression of limited numbers of incoming viral genomes The brainbow cassette Release of Wolbachia infected mosquitoes in Australia (story one, two) Journal articles on Wolbachia infection of mosquitoes (Cell, PloS Pathogens) Wolbachia discussion on TWiV 61 TWiV on Facebook Letters read on TWiV 115 Weekly Science Picks Marc - Homebrew bioreactor (photo, movie) - culture bottle and drive, oil-free vacuum pumps Rich - Logitech Harmony Universal Remote Alan - H.M.S. Challenger Reports Vincent - Sequence of the strawberry genome and blog post by lead author Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no Derek Smith on antigenic cartography http://www.virology.ws/2011/01/07/derek-smith-on-antigenic-cartography/ http://www.virology.ws/2011/01/07/derek-smith-on-antigenic-cartography/#comments Fri, 07 Jan 2011 16:05:04 +0000 Vincent Racaniello http://www.virology.ws/?p=3767

Derek Smith, Professor of Infectious Disease Informatics, University of Cambridge, U.K., has developed a method for visualizing antigenic evolution by creating two-dimensional maps in a process called antigenic cartography. These maps are made with data that provide information on the antigenic properties of the pathogen. In the case of influenza virus, the data come from measuring the ability of an antiviral antibody to inhibit hemagglutination – binding of virions to red blood cells. Such maps show how amino acid changes can affect antibody binding to virus particles, which cannot be done by comparing nucleotide sequences of different virus isolates. By charting influenza virus strains in this way, it should be possible to better understand genetic and antigenic evolution.

I discussed antigenic cartography with Dr. Smith during ICAAC Boston 2010, as part of TWiV 99. View the video below, or right click to download the 292 MB .mp4 file.

]]> http://www.virology.ws/2011/01/07/derek-smith-on-antigenic-cartography/feed/ 1 antigenic cartography,antigenic drift,derek smith,H1N1,H3N2,influenza,pandemic,viral,virology,virus Derek Smith, Professor of Infectious Disease Informatics, University of Cambridge, U.K., has developed a method for visualizing antigenic evolution by creating two-dimensional maps in a process called antigenic cartography. Derek Smith, Professor of Infectious Disease Informatics, University of Cambridge, U.K., has developed a method for visualizing antigenic evolution by creating two-dimensional maps in a process called antigenic cartography. These maps are made with data that provide information on the antigenic properties of the pathogen. In the case of influenza virus, the data come from measuring the ability of an antiviral antibody to inhibit hemagglutination – binding of virions to red blood cells. Such maps show how amino acid changes can affect antibody binding to virus particles, which cannot be done by comparing nucleotide sequences of different virus isolates. By charting influenza virus strains in this way, it should be possible to better understand genetic and antigenic evolution. I discussed antigenic cartography with Dr. Smith during ICAAC Boston 2010, as part of TWiV 99. View the video below, or right click to download the 292 MB .mp4 file. virology blog no TWiV 114: Ten out of ’10 http://www.virology.ws/2011/01/02/twiv-114-ten-out-of-10/ http://www.virology.ws/2011/01/02/twiv-114-ten-out-of-10/#comments Sun, 02 Jan 2011 17:43:12 +0000 Vincent Racaniello http://www.virology.ws/?p=3751

vaccinia plaqueHosts: Vincent Racaniello, Alan Dove, and Rich Condit

On episode #114 of the podcast This Week in Virology, Vincent, Alan, and Rich revisit ten compelling virology stories of 2010.

Click the arrow above to play, or right-click to download TWiV #114 (64 MB .mp3, 88 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Ten virology stories of 2010:

  1. XMRV, CFS, and prostate cancer (TWiV 113, 99, 98, 94, 89, 76, 70, 65)
  2. The ongoing saga of polio eradication (TWiV 110, 79)
  3. Viruses interact with the miRNA/siRNA system (TWiV 108, 72)
  4. Endogenous viruses – retro and beyond (TWiV 105, 91, 88, 65)
  5. Dengue virus progress and new outbreak (TWiV 111, 95, 82)
  6. Colony collapse disorder (TWiV 104)
  7. David Baltimore (TWiV 100)
  8. Ode to a plaque (TWiV 68)
  9. Vaccine contamination with circovirus (TWiV 86, 77, 75)
  10. Universal influenza vaccines (TWiV 107)

Weekly Science Picks

Rich – Elementary schoolchildren publish a science paper (original article and editorial with video) – thanks Kathy!
Alan – White-nose syndrome blog
Vincent – Headway, headlines and healthy skepticism

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2011/01/02/twiv-114-ten-out-of-10/feed/ 2 baltimore,cancer,CFS,circovirus,david,Dengue,endogenous,influenza,miRNA,plaque,polio,prostate Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #114 of the podcast This Week in Virology, Vincent, Alan, and Rich revisit ten compelling virology stories of 2010. - Click the arrow above to play, Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #114 of the podcast This Week in Virology, Vincent, Alan, and Rich revisit ten compelling virology stories of 2010. Click the arrow above to play, or right-click to download TWiV #114 (64 MB .mp3, 88 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Ten virology stories of 2010: XMRV, CFS, and prostate cancer (TWiV 113, 99, 98, 94, 89, 76, 70, 65) The ongoing saga of polio eradication (TWiV 110, 79) Viruses interact with the miRNA/siRNA system (TWiV 108, 72) Endogenous viruses - retro and beyond (TWiV 105, 91, 88, 65) Dengue virus progress and new outbreak (TWiV 111, 95, 82) Colony collapse disorder (TWiV 104) David Baltimore (TWiV 100) Ode to a plaque (TWiV 68) Vaccine contamination with circovirus (TWiV 86, 77, 75) Universal influenza vaccines (TWiV 107) Weekly Science Picks Rich - Elementary schoolchildren publish a science paper (original article and editorial with video) - thanks Kathy! Alan - White-nose syndrome blog Vincent - Headway, headlines and healthy skepticism Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no Rich Condit reminisces http://www.virology.ws/2010/12/28/rich-condit-reminisces/ http://www.virology.ws/2010/12/28/rich-condit-reminisces/#comments Tue, 28 Dec 2010 13:07:52 +0000 Vincent Racaniello http://www.virology.ws/?p=3725

infectious polio rnaOn my recent trip to record TWiV #111 at Florida Gulf Coast University, I visited Rich Condit in Gainesville. There he told me a story about how the bacteriophage T7 polymerase/promoter system was developed. It’s an interesting tale that demonstrates how important scientific advances often have convoluted roots. You can watch the video below or download a high-definition (720p) version (585 MB .mov).

The combination of bacteriophage T7 RNA polymerase and its cognate promoter sequence allows the production of specific RNAs either in vitro or in cells. In many laboratories this system is used to synthesize infectious viral RNA from cloned DNAs. In the example shown, a DNA copy of of the poliovirus RNA genome has been cloned into a bacterial plasmid. The promoter sequence for T7 RNA polymerase is inserted at the 5′-end of the viral sequence (not shown). When placed within any double-stranded DNA, this 19 nucleotide promoter sequence (TAATAGGACTCACTATAGG) will lead to the production of RNA. The plasmid is incubated with purified T7 RNA polymerase (commercially available) and ATP, GTP, UTP and CTP, and the viral RNAs that are produced are then transfected into cells. A viral replication cycle begins, resulting in the production of infectious virus particles.

As described by Rich in the video below, this expression system was conceived by Ed Niles and brought to practice by Bernard Moss. The first paper published described the insertion of the gene encoding T7 RNA polymerase into the genome of vaccinia virus. When cells are infected with the recombinant virus, they produce T7 RNA polymerase. To express a protein using this system, a gene is cloned into a plasmid next to the T7 RNA polymerase promoter. When this plasmid is introduced into cells producing T7 RNA polymerase, RNAs are made which are then translated into protein.

This method was subsequently modified by Wimmer and colleagues to synthesize infectious poliovirus RNA in vitro.

Werf, S. (1986). Synthesis of Infectious Poliovirus RNA by Purified T7 RNA Polymerase Proceedings of the National Academy of Sciences, 83 (8), 2330-2334 DOI: 10.1073/pnas.83.8.2330

Fuerst, T. (1986). Eukaryotic Transient-Expression System Based on Recombinant Vaccinia Virus that Synthesizes Bacteriophage T7 RNA Polymerase Proceedings of the National Academy of Sciences, 83 (21), 8122-8126 DOI: 10.1073/pnas.83.21.8122

]]> http://www.virology.ws/2010/12/28/rich-condit-reminisces/feed/ 7 bacteriophage,condit,poliovirus,promoter,t7 polymerase,vaccinia,viral,virology,virus On my recent trip to record TWiV #111 at Florida Gulf Coast University, I visited Rich Condit in Gainesville. There he told me a story about how the bacteriophage T7 polymerase/promoter system was developed. On my recent trip to record TWiV #111 at Florida Gulf Coast University, I visited Rich Condit in Gainesville. There he told me a story about how the bacteriophage T7 polymerase/promoter system was developed. It's an interesting tale that demonstrates how important scientific advances often have convoluted roots. You can watch the video below or download a high-definition (720p) version (585 MB .mov). The combination of bacteriophage T7 RNA polymerase and its cognate promoter sequence allows the production of specific RNAs either in vitro or in cells. In many laboratories this system is used to synthesize infectious viral RNA from cloned DNAs. In the example shown, a DNA copy of of the poliovirus RNA genome has been cloned into a bacterial plasmid. The promoter sequence for T7 RNA polymerase is inserted at the 5'-end of the viral sequence (not shown). When placed within any double-stranded DNA, this 19 nucleotide promoter sequence (TAATAGGACTCACTATAGG) will lead to the production of RNA. The plasmid is incubated with purified T7 RNA polymerase (commercially available) and ATP, GTP, UTP and CTP, and the viral RNAs that are produced are then transfected into cells. A viral replication cycle begins, resulting in the production of infectious virus particles. As described by Rich in the video below, this expression system was conceived by Ed Niles and brought to practice by Bernard Moss. The first paper published described the insertion of the gene encoding T7 RNA polymerase into the genome of vaccinia virus. When cells are infected with the recombinant virus, they produce T7 RNA polymerase. To express a protein using this system, a gene is cloned into a plasmid next to the T7 RNA polymerase promoter. When this plasmid is introduced into cells producing T7 RNA polymerase, RNAs are made which are then translated into protein. This method was subsequently modified by Wimmer and colleagues to synthesize infectious poliovirus RNA in vitro. Werf, S. (1986). Synthesis of Infectious Poliovirus RNA by Purified T7 RNA Polymerase Proceedings of the National Academy of Sciences, 83 (8), 2330-2334 DOI: 10.1073/pnas.83.8.2330 Fuerst, T. (1986). Eukaryotic Transient-Expression System Based on Recombinant Vaccinia Virus that Synthesizes Bacteriophage T7 RNA Polymerase Proceedings of the National Academy of Sciences, 83 (21), 8122-8126 DOI: 10.1073/pnas.83.21.8122 virology blog no TWiV 113: Alan Rein on XMRV http://www.virology.ws/2010/12/26/twiv-113-alan-rein-on-xmrv/ http://www.virology.ws/2010/12/26/twiv-113-alan-rein-on-xmrv/#comments Sun, 26 Dec 2010 21:56:38 +0000 Vincent Racaniello http://www.virology.ws/?p=3733

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Alan Rein

rich conditOn episode #113 of the podcast This Week in Virology, Vincent, Alan, and Rich discuss the retrovirus XMRV with retrovirologist Alan Rein of the National Cancer Institute.

Click the arrow above to play, or right-click to download TWiV #113 (55 MB .mp3, 76 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Rich – Word Lens
Alan – Tetenal Press Kit
Vincent – In the pipeline and Things I won’t work with by Derek Lowe

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/12/26/twiv-113-alan-rein-on-xmrv/feed/ 31 CFS,chronic fatigue syndrome,prostate cancer,retrovirus,TWiV,viral,virology,virus,xmrv Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Alan Rein On episode #113 of the podcast This Week in Virology, Vincent, Alan, and Rich discuss the retrovirus XMRV with retrovirologist Alan Rein of the National Cancer Institute. - Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Alan Rein On episode #113 of the podcast This Week in Virology, Vincent, Alan, and Rich discuss the retrovirus XMRV with retrovirologist Alan Rein of the National Cancer Institute. Click the arrow above to play, or right-click to download TWiV #113 (55 MB .mp3, 76 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: XMRV: A new virus is prostate cancer? (Cancer Research) Detection of XMRV in normal and prostate tumor tissue (J Inf Dis) Reach for a scorecard (commentary, J Inf Dis) Retrovirology papers: one, two, three, four, commentary Integration sites of XMRV in prostate tumor DNA (J Virol, PLoS One) TWiV on Facebook Letters read on TWiV 113 Weekly Science Picks Rich - Word Lens Alan - Tetenal Press Kit Vincent - In the pipeline and Things I won't work with by Derek Lowe Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 112: Creating a killer poxvirus http://www.virology.ws/2010/12/19/twiv-112-creating-a-killer-poxvirus/ http://www.virology.ws/2010/12/19/twiv-112-creating-a-killer-poxvirus/#comments Sun, 19 Dec 2010 18:45:01 +0000 Vincent Racaniello http://www.virology.ws/?p=3701

dickson despommierHosts: Vincent Racaniello, Alan Dove, and Rich Condit

On episode #112 of the podcast This Week in Virology, Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes.

Click the arrow above to play, or right-click to download TWiV #112(71 MB .mp3, 98 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Rich – The Scientist’s Top 10 Innovations 2010
Alan – Avian Vocalizations Center
Vincent – Microbial soap from Cleaner Science (thanks, Nadia!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/12/19/twiv-112-creating-a-killer-poxvirus/feed/ 0 bioterrorism,complement,ectromelia,H1N1,influenza,pandemic,podcast. twiv,poxvirus,smallpox,vaccinia,viral,virology Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #112 of the podcast This Week in Virology, Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #112 of the podcast This Week in Virology, Vincent, Alan, and Rich review the making of a virulent poxvirus by insertion of the gene encoding IL-4, and severe 2009 H1N1 influenza due to pathogenic immune complexes. Click the arrow above to play, or right-click to download TWiV #112(71 MB .mp3, 98 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Expression of IL-4 makes a killer poxvirus Additional studies on poxvirus-IL-4 recombinants Creation of killer poxvirus could have been predicted Interleukin regulation of Th responses Severe pandemic H1N1 disease due to immune complexes Unusually high influenza mortality in 18-65 years old The complement system TWiV on Facebook Letters read on TWiV 112 Weekly Science Picks Rich - The Scientist's Top 10 Innovations 2010 Alan - Avian Vocalizations Center Vincent - Microbial soap from Cleaner Science (thanks, Nadia!) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiP 20: The whipworm Trichuris trichiura http://www.virology.ws/2010/12/16/twip-20-the-whipworm-trichuris-trichiura/ http://www.virology.ws/2010/12/16/twip-20-the-whipworm-trichuris-trichiura/#comments Fri, 17 Dec 2010 02:59:10 +0000 Vincent Racaniello http://www.virology.ws/?p=3693

Hosts: Vincent Racaniello and Dickson Despommier

On episode 20 of the podcast This Week in Parasitism, Vincent and Dickson continue their discussion of nematodes with the whipworm Trichuris trichiura.

Click the arrow above to play, or right-click to download

TWiP is brought to you by the American Society for Microbiology at Microbeworld.org.

Links for this episode:

Download TWiP #20 (64 MB .mp3, 89 minutes)

Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email

Send your questions and comments to twip@twiv.tv

]]> http://www.virology.ws/2010/12/16/twip-20-the-whipworm-trichuris-trichiura/feed/ 1 nematode,parasite,parasitism,podcast,trichuris trichiura,twip,whipworm Hosts: Vincent Racaniello and Dickson Despommier On episode 20 of the podcast This Week in Parasitism, Vincent and Dickson continue their discussion of nematodes with the whipworm Trichuris trichiura. - Click the arrow above to play, Hosts: Vincent Racaniello and Dickson Despommier On episode 20 of the podcast This Week in Parasitism, Vincent and Dickson continue their discussion of nematodes with the whipworm Trichuris trichiura. Click the arrow above to play, or right-click to download TWiP is brought to you by the American Society for Microbiology at Microbeworld.org. Links for this episode: Trichuris trichiura adult female (jpg) Trichuris trichiura adult male (jpg) Trichuris trichiura in situ (jpg) Trichuris trichiura life cycle (jpg) Exploitation of the intestinal microflora by T. muris Letters read on TWiP 20 Download TWiP #20 (64 MB .mp3, 89 minutes) Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email Send your questions and comments to twip@twiv.tv virology blog no TWiV 111: Live at Florida Gulf Coast University http://www.virology.ws/2010/12/13/twiv-111-live-at-florida-gulf-coast-university/ http://www.virology.ws/2010/12/13/twiv-111-live-at-florida-gulf-coast-university/#comments Mon, 13 Dec 2010 19:04:09 +0000 Vincent Racaniello http://www.virology.ws/?p=3687

TWiV at FGCUHosts: Vincent Racaniello, Alan Dove, Rich Condit, Ed Fussell, Andrea Leal, and Amy Sargent

On episode #111 of the podcast This Week in Virology, the TWiV crew meets with members of the Florida Keys Mosquito Control District at Florida Gulf Coast University to discuss dengue in Florida and how to control it.

Click the arrow above to play, or right-click to download TWiV #111 (76 MB .mp3, 105 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Rich – At the Bench, A Laboratory Navigator by Kathy Barker
Alan – DEEP Indonesia Underwater Photo Contest 2010 Winners
Vincent – HHMI resources for early-career scientists

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/12/13/twiv-111-live-at-florida-gulf-coast-university/feed/ 2 Dengue,mosquito,viral,virology,virus Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Ed Fussell, Andrea Leal, and Amy Sargent On episode #111 of the podcast This Week in Virology, the TWiV crew meets with members of the Florida Keys Mosquito Control District at Florida Gulf Coast Un... Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Ed Fussell, Andrea Leal, and Amy Sargent On episode #111 of the podcast This Week in Virology, the TWiV crew meets with members of the Florida Keys Mosquito Control District at Florida Gulf Coast University to discuss dengue in Florida and how to control it. Click the arrow above to play, or right-click to download TWiV #111 (76 MB .mp3, 105 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Florida Keys Mosquito Control District Prof. Sharon Isern Florida Gulf Coast University CDC report on dengue in the Florida Keys Dengue in Miami Mosquito release in the Caymans (Oxitec press release - pdf) Concerns about mosquito release TWiV on Facebook - photos of TWiV 111 Letters read on TWiV 111 Video of this episode - Download .mp4 (136 MB) or .wmv (457 MB) or view below Weekly Science Picks Rich - At the Bench, A Laboratory Navigator by Kathy Barker Alan - DEEP Indonesia Underwater Photo Contest 2010 Winners Vincent - HHMI resources for early-career scientists Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 110: CSI virology http://www.virology.ws/2010/12/05/twiv-110-csi-virology/ http://www.virology.ws/2010/12/05/twiv-110-csi-virology/#comments Mon, 06 Dec 2010 03:18:40 +0000 Vincent Racaniello http://www.virology.ws/?p=3669

Alan DoveHosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

On episode #110 of the podcast This Week in Virology, Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, the passing of Frank Fenner, polio outbreak in The Congo, solving criminal cases of HIV transmission, and classifying viruses by capsid structure.

Click the arrow above to play, or right-click to download TWiV #110 (68 MB .mp3, 93 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Dickson – CDC’s West Nile virus case count for 2010
Rich – The red bees of Red Hook
Alan – Arsenic-based life at XKCD
Vincent – PLoS iPad app

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/12/05/twiv-110-csi-virology/feed/ 0 arsenic,bacteria,capsid,congo,frank fenner,HIV,ICTV,mono lake,OPV,paraphyly,polio,poxvirus Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #110 of the podcast This Week in Virology, Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #110 of the podcast This Week in Virology, Vincent, Alan, Rich, and Dickson discuss bacteria that can utilize arsenic in place of phosphorus, the passing of Frank Fenner, polio outbreak in The Congo, solving criminal cases of HIV transmission, and classifying viruses by capsid structure. Click the arrow above to play, or right-click to download TWiV #110 (68 MB .mp3, 93 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Bacteria that utilize arsenic (Ed Yong's view) Frank Fenner passes away Smallpox and its eradication - the 'red book' (pdf) Polio outbreak in The Congo (virus isolation) Solving criminal cases with HIV evolution (press release) Definition of paraphyly Order to the viral universe International Committee on Taxonomy of Viruses (ICTV) TWiV on Facebook Letters read on TWiV 110 Weekly Science Picks Dickson - CDC's West Nile virus case count for 2010 Rich - The red bees of Red Hook Alan - Arsenic-based life at XKCD Vincent - PLoS iPad app Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no Futures in Biotech 71: Genomics, Proteomics, Cellular Immunity, and Anti-Matter http://www.virology.ws/2010/11/30/futures-in-biotech-71-genomics-proteomics-cellular-immunity-and-anti-matter/ http://www.virology.ws/2010/11/30/futures-in-biotech-71-genomics-proteomics-cellular-immunity-and-anti-matter/#comments Tue, 30 Nov 2010 20:39:39 +0000 Vincent Racaniello http://www.virology.ws/?p=3653

I joined Marc Pelletier, Andre Nantel, and George Farr on futures-in-biotechepisode 71 of Futures in Biotech for a conversation about the 1000 genome project, the billion dollar human proteome, how antibodies block viral infection, and capturing anti-matter.

Download audio FiB #71 (42 MB .mp3, 87 minutes)


Download video (211 MB .mp4)

]]> http://www.virology.ws/2010/11/30/futures-in-biotech-71-genomics-proteomics-cellular-immunity-and-anti-matter/feed/ 0 antibody,neutralization,trim21,viral,virology,virus I joined Marc Pelletier, Andre Nantel, and George Farr on episode 71 of Futures in Biotech for a conversation about the 1000 genome project, the billion dollar human proteome, how antibodies block viral infection, and capturing anti-matter. - I joined Marc Pelletier, Andre Nantel, and George Farr on episode 71 of Futures in Biotech for a conversation about the 1000 genome project, the billion dollar human proteome, how antibodies block viral infection, and capturing anti-matter. Download audio FiB #71 (42 MB .mp3, 87 minutes) Download video (211 MB .mp4) virology blog no TWiV 109: Virologia en México http://www.virology.ws/2010/11/28/twiv-109-virologia-en-mexico/ http://www.virology.ws/2010/11/28/twiv-109-virologia-en-mexico/#comments Mon, 29 Nov 2010 03:58:52 +0000 Vincent Racaniello http://www.virology.ws/?p=3651

Hosts: Vincent Racaniello, Rosa Maria del Angel, and Ana Lorena Gutiérrez

On episode #109 of the podcast This Week in Virology, Vincent visits Mexico City and speaks with Rosa Maria del Angel and Ana Lorena Gutiérrez about virology in Mexico, and their work on dengue and caliciviruses.

Click the arrow above to play, or right-click to download TWiV #109 (58 MB .mp3, 80 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Lorena – Caliciviruses by Hansman, Jiang, and Green
Vincent – Insights into dengue virus genome replication by Alcaraz-Estrada, Yocupicio, and del Angel

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/11/28/twiv-109-virologia-en-mexico/feed/ 2 calicivirus,Dengue,Mexico,mexico city,podcast,TWiV,viral,virology,virus Hosts: Vincent Racaniello, Rosa Maria del Angel, and Ana Lorena Gutiérrez On episode #109 of the podcast This Week in Virology, Vincent visits Mexico City and speaks with Rosa Maria del Angel and Ana Lorena Gutiérrez about virology in Mexico, Hosts: Vincent Racaniello, Rosa Maria del Angel, and Ana Lorena Gutiérrez On episode #109 of the podcast This Week in Virology, Vincent visits Mexico City and speaks with Rosa Maria del Angel and Ana Lorena Gutiérrez about virology in Mexico, and their work on dengue and caliciviruses. Click the arrow above to play, or right-click to download TWiV #109 (58 MB .mp3, 80 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Rosa's PNAS paper on proteins that bind poliovirus RNA Lorena's papers on influence of proteins that bind poliovirus RNA on tropism and attenuation CINVESTAV TWiV on Facebook Weekly Science Picks Lorena - Caliciviruses by Hansman, Jiang, and Green Vincent - Insights into dengue virus genome replication by Alcaraz-Estrada, Yocupicio, and del Angel Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 108: Barking up the right Tre http://www.virology.ws/2010/11/21/twiv-108-barking-up-the-right-tre/ http://www.virology.ws/2010/11/21/twiv-108-barking-up-the-right-tre/#comments Sun, 21 Nov 2010 21:56:16 +0000 Vincent Racaniello http://www.virology.ws/?p=3638

twivHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Saul Silverstein

On episode #108 of the podcast This Week in Virology, Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, and down-regulation of a host microRNA by a viral noncoding RNA.

Click the arrow above to play, or right-click to download TWiV #108 (64 MB .mp3, 89 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Rich – Where cinema and biology meet
Alan – Qiagen iApp
Vincent – Ask a biologist

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/11/21/twiv-108-barking-up-the-right-tre/feed/ 0 AIDS,cre,HIV,miRNA,recombinase,rnai,tre,TWiV,viral,virology,virus Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Saul Silverstein On episode #108 of the podcast This Week in Virology, Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Saul Silverstein On episode #108 of the podcast This Week in Virology, Vincent, Alan, Rich, and Saul review the evolution of HIV-1 specific recombinases, and down-regulation of a host microRNA by a viral noncoding RNA. Click the arrow above to play, or right-click to download TWiV #108 (64 MB .mp3, 89 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: HIV-1 proviral excision with an evolved recombinase Evolution of HIV-1 specific recombinases - review article Down-regulation of a host miRNA by a viral noncoding RNA Paring miRNAs through pairing - commentary GM mosquitoes wipe out dengue Virology faculty position, University of Maryland TWiV on Facebook Letters read on TWiV 108 Weekly Science Picks Rich - Where cinema and biology meet Alan - Qiagen iApp Vincent - Ask a biologist Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiP 19: Enterobius vermicularis, the pinworm http://www.virology.ws/2010/11/20/twip-19-enterobius-vermicularis-the-pinworm/ http://www.virology.ws/2010/11/20/twip-19-enterobius-vermicularis-the-pinworm/#comments Sat, 20 Nov 2010 18:23:42 +0000 Vincent Racaniello http://www.virology.ws/?p=3634

Hosts: Vincent Racaniello and Dickson Despommier

On episode 19 of the podcast This Week in Parasitism, Vincent and Dickson move on to nematodes with a discussion of the pinworm.

Click the arrow above to play, or right-click to download

TWiP is brought to you by the American Society for Microbiology at Microbeworld.org.

Links for this episode:

Download TWiP #19 (60 MB .mp3, 82 minutes)

Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email

Send your questions and comments to twip@twiv.tv

]]> http://www.virology.ws/2010/11/20/twip-19-enterobius-vermicularis-the-pinworm/feed/ 1 Despommier,enterobius vermicularis,parasite,parasitism,pinworm,racaniello,twip Hosts: Vincent Racaniello and Dickson Despommier On episode 19 of the podcast This Week in Parasitism, Vincent and Dickson move on to nematodes with a discussion of the pinworm. - Click the arrow above to play, or right-click to download - Hosts: Vincent Racaniello and Dickson Despommier On episode 19 of the podcast This Week in Parasitism, Vincent and Dickson move on to nematodes with a discussion of the pinworm. Click the arrow above to play, or right-click to download TWiP is brought to you by the American Society for Microbiology at Microbeworld.org. Links for this episode: Enterobius vermicularis adult female (jpg) Enterobius vermicularis in appendix (jpg) Enterobius vermicularis embryonated eggs (jpg) Enterobius vermicularis life cycle (jpg) Letters read on TWiP 19 Download TWiP #19 (60 MB .mp3, 82 minutes) Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email Send your questions and comments to twip@twiv.tv virology blog no TWiV 107: Warning – this virus contains email http://www.virology.ws/2010/11/14/twiv-107-warning-this-virus-contains-email/ http://www.virology.ws/2010/11/14/twiv-107-warning-this-virus-contains-email/#comments Mon, 15 Nov 2010 02:46:32 +0000 Vincent Racaniello http://www.virology.ws/?p=3610

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

On episode #107 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich answer listener questions about poliovirus, social media, dengue, influenza, evolution, gel filtration, and much more.

Click the arrow above to play, or right-click to download TWiV #107 (68 MB .mp3, 94 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Rich – Protein Synthesis: An epic on the cellular level
Dickson – The Patchwork Mouse by Joseph R. Hixson
Alan – Bill Hammack’s engineering videos
Vincent – Visual Science (thanks, Svetlana)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/11/14/twiv-107-warning-this-virus-contains-email/feed/ 1 apobec,colony collapse,Dengue,email,evolution,gel filtration,influenza,mitochondria,poliovirus,prokaryote,social media,telomere Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #107 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich answer listener questions about poliovirus, social media, dengue, influenza, evolution, Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #107 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich answer listener questions about poliovirus, social media, dengue, influenza, evolution, gel filtration, and much more. Click the arrow above to play, or right-click to download TWiV #107 (68 MB .mp3, 94 minutes). Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: tre recombinase: paper one and two Universal influenza vaccines Mitochondrial and chlorophast phage-type RNA polymerase in plants Protein Data Bank Letters read on TWiV 107 Weekly Science Picks Rich - Protein Synthesis: An epic on the cellular level Dickson - The Patchwork Mouse by Joseph R. Hixson Alan - Bill Hammack's engineering videos Vincent - Visual Science (thanks, Svetlana) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 106: Making viral DNA II http://www.virology.ws/2010/11/06/twiv-106-making-viral-dna-ii/ http://www.virology.ws/2010/11/06/twiv-106-making-viral-dna-ii/#comments Sat, 06 Nov 2010 21:29:20 +0000 Vincent Racaniello http://www.virology.ws/?p=3601

the 5prime end problemHosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

On episode #106 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes replicate their genetic information.

Click the arrow above to play, or right-click to download TWiV #106 (69 MB .mp3, 95 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

  • Figures for this episode (pdf)
  • Letters read on TWiV 106
  • Video of this episode – download .mov or .wmv or view below


Weekly Science Picks

Rich – Google Health
Dickson – The Neandertal genome
Vincent – Lab techniques videos (thanks, Erik!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/11/06/twiv-106-making-viral-dna-ii/feed/ 0 adenovirus,DNA,dna synthesis,double helix,genome,herpesvirus,parvovirus,polymerase,poxvirus,replication,viral,virology Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit On episode #106 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes repli... Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit On episode #106 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes replicate their genetic information. Click the arrow above to play, or right-click to download TWiV #106 (69 MB .mp3, 95 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Figures for this episode (pdf) Letters read on TWiV 106 Video of this episode - download .mov or .wmv or view below Weekly Science Picks Rich - Google Health Dickson - The Neandertal genome Vincent - Lab techniques videos (thanks, Erik!) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 105: Finches score again http://www.virology.ws/2010/10/31/twiv-105-finches-score-again/ http://www.virology.ws/2010/10/31/twiv-105-finches-score-again/#comments Sun, 31 Oct 2010 17:55:39 +0000 Vincent Racaniello http://www.virology.ws/?p=3592

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

On episode #105 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich review eradication of rinderpest, endogenous hepatitis B virus in the zebra finch genome, and identification of the cell receptor for an extinct retrovirus.

Click the arrow above to play, or right-click to download TWiV #105 (66 MB .mp3, 92 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Dickson – Winged Migration
Alan – Web-accessible shortwave receivers
Rich – Personal Genome Project
Vincent – XVIVO scientific animation

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/10/31/twiv-105-finches-score-again/feed/ 0 endogenous virus,eradication,hepadnavirus,hepatitis b virus,morbillivirus,receptor,retrovirus,rinderpest,viral,virology,virus,zebra finch Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #105 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich review eradication of rinderpest, endogenous hepatitis B virus in the zebra finch genome, Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #105 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich review eradication of rinderpest, endogenous hepatitis B virus in the zebra finch genome, and identification of the cell receptor for an extinct retrovirus. Click the arrow above to play, or right-click to download TWiV #105 (66 MB .mp3, 92 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Eradication of rinderpest Rinderpest in the Merck Veterinary Manual Rinderpest summary (pdf) Manual on the preparation of rinderpest contingency plans Walter Plowright obituary The Plowright vaccine Measles evolution from rinderpest Endogenous hepadnaviruses in the genome of the zebra finch (PLoS One) Receptor for an extinct retrovirus (PNAS) Vertical farm: NPR post and YouTube video Letters read on TWiV 105 Weekly Science Picks Dickson - Winged Migration Alan - Web-accessible shortwave receivers Rich - Personal Genome Project Vincent - XVIVO scientific animation Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no Futures in Biotech 69: The power of yeast genetics http://www.virology.ws/2010/10/30/futures-in-biotech-69-the-power-of-yeast-genetics/ http://www.virology.ws/2010/10/30/futures-in-biotech-69-the-power-of-yeast-genetics/#comments Sat, 30 Oct 2010 12:00:17 +0000 Vincent Racaniello http://www.virology.ws/?p=3585

I joined Marc Pelletier on futures-in-biotechepisode 60 of Futures in Biotech for a conversation with Malcolm Whiteway about one of the most powerful genetic model systems: Saccharomyces cerevisiae.

Download FiB #69 (46 MB .mp3, 95 minutes)


Download video (231 MB .mp4)

]]> http://www.virology.ws/2010/10/30/futures-in-biotech-69-the-power-of-yeast-genetics/feed/ 1 candida,fib,genetics,pelletier,saccharomyces,viral,virology,virus,yeast I joined Marc Pelletier on episode 60 of Futures in Biotech for a conversation with Malcolm Whiteway about one of the most powerful genetic model systems: Saccharomyces cerevisiae. - Download FiB #69 (46 MB .mp3, 95 minutes) - I joined Marc Pelletier on episode 60 of Futures in Biotech for a conversation with Malcolm Whiteway about one of the most powerful genetic model systems: Saccharomyces cerevisiae. Download FiB #69 (46 MB .mp3, 95 minutes) Download video (231 MB .mp4) virology blog no TWiP 18: Cryptosporidium http://www.virology.ws/2010/10/27/twip-18-cryptosporidium/ http://www.virology.ws/2010/10/27/twip-18-cryptosporidium/#comments Wed, 27 Oct 2010 11:50:17 +0000 Vincent Racaniello http://www.virology.ws/?p=3567

Hosts: Vincent Racaniello and Dickson Despommier

On episode 18 of the podcast This Week in Parasitism, Vincent and Dickson discuss the intracellular parasite Cryptosporidium, which causes diarrheal disease in most mammalian species.

Click the arrow above to play, or right-click to download

TWiP is brought to you by the American Society for Microbiology at Microbeworld.org.

Links for this episode:

Download TWiP #18 (58 MB .mp3, 80 minutes)

Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email

Send your questions and comments to twip@twiv.tv

]]> http://www.virology.ws/2010/10/27/twip-18-cryptosporidium/feed/ 3 cryptosporidium,Despommier,diarrhea,meront,parasite,parasitism,racaniello,twip Hosts: Vincent Racaniello and Dickson Despommier On episode 18 of the podcast This Week in Parasitism, Vincent and Dickson discuss the intracellular parasite Cryptosporidium, which causes diarrheal disease in most mammalian species. - Hosts: Vincent Racaniello and Dickson Despommier On episode 18 of the podcast This Week in Parasitism, Vincent and Dickson discuss the intracellular parasite Cryptosporidium, which causes diarrheal disease in most mammalian species. Click the arrow above to play, or right-click to download TWiP is brought to you by the American Society for Microbiology at Microbeworld.org. Links for this episode: Cryptosporidium parvum electron micrograph (jpg) Cryptosporidium parvum meronts (jpg) Cryptosporidium parvum life cycle (jpg) Cryptosporidium page at CDC Letters read on TWiP 18 Download TWiP #18 (58 MB .mp3, 80 minutes) Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email Send your questions and comments to twip@twiv.tv virology blog no TWiV 104: The colony-collapse blues http://www.virology.ws/2010/10/24/twiv-104-the-colony-collapse-blues/ http://www.virology.ws/2010/10/24/twiv-104-the-colony-collapse-blues/#comments Mon, 25 Oct 2010 01:21:13 +0000 Vincent Racaniello http://www.virology.ws/?p=3533

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

On episode #104 of the podcast This Week in Virology, the entire TWiV family reviews the latest ideas about colony collapse disorder of honeybees, and resurgence of monkeypox in Africa.

Click the arrow above to play, or right-click to download TWiV #104 (70 MB .mp3, 97 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Dickson – Four Fish by Paul Greenberg
Alan – Nikon Small World contest, 2010 winners
Rich – Encyclopedia of Life
Vincent – First all-digital science textbook will be free (thanks, @windsurfer)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/10/24/twiv-104-the-colony-collapse-blues/feed/ 1 colony collapse,honeybee,iridovirus,microsporidian,monkeypox,nosema,smallpox,viral,virology,virus Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #104 of the podcast This Week in Virology, the entire TWiV family reviews the latest ideas about colony collapse disorder of honeybees, Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #104 of the podcast This Week in Virology, the entire TWiV family reviews the latest ideas about colony collapse disorder of honeybees, and resurgence of monkeypox in Africa. Click the arrow above to play, or right-click to download TWiV #104 (70 MB .mp3, 97 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: The Harvey Lectures Iridovirus and microsporidian linked to colony collapse disorder CCD discussed previously on TWiV 64, 49, and 46 Why are they called iridoviruses? Iridoviruses at ViralZone Scientists and soldiers solve a bee mystery (NY Times, pdf) Edgewood research center involvement in CCD Resurgence of monkeypox in Africa (PNAS) Orthopoxvirus in Ghana Outbreak of monkeypox in US (MMWR) Goodbye smallpox vaccination, hello monkeypox Letters read on TWiV 104 Weekly Science Picks Dickson - Four Fish by Paul Greenberg Alan - Nikon Small World contest, 2010 winners Rich - Encyclopedia of Life Vincent - First all-digital science textbook will be free (thanks, @windsurfer) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 103: Shots with LJ Tan http://www.virology.ws/2010/10/17/twiv-103-shots-with-lj-tan/ http://www.virology.ws/2010/10/17/twiv-103-shots-with-lj-tan/#comments Sun, 17 Oct 2010 19:35:05 +0000 Vincent Racaniello http://www.virology.ws/?p=3515

Hosts: Vincent Racaniello, Alan Dove, and LJ Tan

On Episode 103 of the podcast This Week in Virology, Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association.

Click the arrow above to play, or right-click to download TWiV #103 (56 MB .mp3, 77 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Alan – BioGene, an iApp
Vincent – The Vertical Farm by Dickson Despommier

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/10/17/twiv-103-shots-with-lj-tan/feed/ 0 adjuvant,Flu,influenza,lj tan,pandemic,podcast,TWiV,vaccine,viral,virology,virus Hosts: Vincent Racaniello, Alan Dove, and LJ Tan On Episode 103 of the podcast This Week in Virology, Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association. - Click the arrow above to play, Hosts: Vincent Racaniello, Alan Dove, and LJ Tan On Episode 103 of the podcast This Week in Virology, Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association. Click the arrow above to play, or right-click to download TWiV #103 (56 MB .mp3, 77 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: The American Medical Association Prevent Influenza Now Vaccine injury claim reaches Supreme Court Supreme Court divided on vaccine case No narcolepsy link to flu vaccine Letters read on TWiV 103 Weekly Science Picks Alan - BioGene, an iApp Vincent - The Vertical Farm by Dickson Despommier Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 102: Catch me if you can in Munich http://www.virology.ws/2010/10/10/twiv-102-catch-me-if-you-can-in-munich/ http://www.virology.ws/2010/10/10/twiv-102-catch-me-if-you-can-in-munich/#comments Mon, 11 Oct 2010 00:06:02 +0000 Vincent Racaniello http://www.virology.ws/?p=3494

Hosts: Vincent Racaniello, Andrew Baker, Karl-Klaus Conzelmann, Peter Palese, and Katharina Eisenächer

Episode #102 of the podcast This Week in Virology is a conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.

Click the arrow above to play, or right-click to download TWiV #102 (67 MB .mp3, 95 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:


Weekly Science Picks

Katharina – Deutsches Museum
Vincent – HHMI holiday lectures on science (thanks Judi!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/10/10/twiv-102-catch-me-if-you-can-in-munich/feed/ 2 adenovirus,cardiovascular disease,Flu,gene therapy,influenza virus,innate immunity,mononegavirales,rabies,RIG-I,sfb455,vaccine,viral Hosts: Vincent Racaniello, Andrew Baker, Karl-Klaus Conzelmann, Peter Palese, and Katharina Eisenächer Episode #102 of the podcast This Week in Virology is a conversation about the RNA sensor RIG-I, adenovirus gene therapy, Hosts: Vincent Racaniello, Andrew Baker, Karl-Klaus Conzelmann, Peter Palese, and Katharina Eisenächer Episode #102 of the podcast This Week in Virology is a conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’. Click the arrow above to play, or right-click to download TWiV #102 (67 MB .mp3, 95 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: SFB455 Symposium scientific program Letters read on TWiV 102 Virologists having fun (YouTube video) Video of this episode - view below or download .mov (394 MB) or .wmv (506 MB) Weekly Science Picks Katharina - Deutsches Museum Vincent - HHMI holiday lectures on science (thanks Judi!) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiP 17: Entamoeba histolytica http://www.virology.ws/2010/10/06/twip-17-entamoeba-histolytica/ http://www.virology.ws/2010/10/06/twip-17-entamoeba-histolytica/#comments Wed, 06 Oct 2010 22:54:40 +0000 Vincent Racaniello http://www.virology.ws/?p=3489

Hosts: Vincent Racaniello and Dickson Despommier

On episode 17 of the podcast This Week in Parasitism, Vincent and Dickson continue their discussion of protozoan parasites that cause diarrhea with a review of amebic dysentery caused by Entamoeba histolytica.

Click the arrow above to play, or right-click to download

TWiP is brought to you by the American Society for Microbiology at Microbeworld.org.

Links for this episode:

Download TWiP #17 (55 MB .mp3, 76 minutes)

Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email

Send your questions and comments to twip@twiv.tv

]]> http://www.virology.ws/2010/10/06/twip-17-entamoeba-histolytica/feed/ 2 amoeba,amoebae,Despommier,dysentery,entamoeba histolytica,parasite,parasitism,racaniello,twip Hosts: Vincent Racaniello and Dickson Despommier On episode 17 of the podcast This Week in Parasitism, Vincent and Dickson continue their discussion of protozoan parasites that cause diarrhea with a review of amebic dysentery caused by Entamoeba histo... Hosts: Vincent Racaniello and Dickson Despommier On episode 17 of the podcast This Week in Parasitism, Vincent and Dickson continue their discussion of protozoan parasites that cause diarrhea with a review of amebic dysentery caused by Entamoeba histolytica. Click the arrow above to play, or right-click to download TWiP is brought to you by the American Society for Microbiology at Microbeworld.org. Links for this episode: Entamoeba histolytica cyst Entamoeba histolytica trophozoite Entamoeba histolytica life cycle Galactose prevents attachment of amoebae to cells Entamoeba histolytica life cycle Charcot-Leyden crystal Letters read on TWiP 17 Download TWiP #17 (55 MB .mp3, 76 minutes) Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email Send your questions and comments to twip@twiv.tv virology blog no TWiV #101: Sizing up adenovirus http://www.virology.ws/2010/10/03/twiv-101-sizing-up-adenovirus/ http://www.virology.ws/2010/10/03/twiv-101-sizing-up-adenovirus/#comments Sun, 03 Oct 2010 20:22:07 +0000 Vincent Racaniello http://www.virology.ws/?p=3479

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Hamish Young

On episode #101 of the podcast This Week in Virology, Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity.

Click the arrow above to play, or right-click to download TWiV #101 (55 MB .mp3, 76 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Alan – National Geographic’s Best Environmental Photographs of 2010
Rich – Richard Feynman lecture: The pleasure of finding things out
Vincent – Summary of the First International XMRV Workshop (pdf)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/10/03/twiv-101-sizing-up-adenovirus/feed/ 0 adenovirus,cryoEM,obesity,podcast,TWiV,viral,virology,virus,virus structure,Xray crystallography Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Hamish Young On episode #101 of the podcast This Week in Virology, Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Hamish Young On episode #101 of the podcast This Week in Virology, Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity. Click the arrow above to play, or right-click to download TWiV #101 (55 MB .mp3, 76 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Three-dimensional structure of adenovirus solved by x-ray crystallography and Cryo-EM Movies of adenovirus Commentary on adenovirus structure Adenovirus picture book Adenovirus type 36 and obesity in children and adolescents Press release on adenovirus 36 and obesity How much TWiV do you want? Take the survey Pre-order The Vertical Farm by Dickson Despommier Letters read on TWiV 101 Weekly Science Picks Alan - National Geographic's Best Environmental Photographs of 2010 Rich - Richard Feynman lecture: The pleasure of finding things out Vincent - Summary of the First International XMRV Workshop (pdf) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no Why John Coffin doesn’t sleep well http://www.virology.ws/2010/10/02/why-john-coffin-doesnt-sleep-well/ http://www.virology.ws/2010/10/02/why-john-coffin-doesnt-sleep-well/#comments Sat, 02 Oct 2010 15:47:48 +0000 Vincent Racaniello http://www.virology.ws/?p=3470

John Coffin, Professor of Genetics and Molecular Microbiology at Tufts University, studies the molecular biology and evolution of retroviruses. He wrote a commentary (A new virus for old diseases?) that accompanied the publication by Lombardi and colleagues of the finding of the new retrovirus XMRV in patients with chronic fatigue syndrome, and has spoken widely about whether this virus has a causative role in the disease. In this video he expresses cautious optimism about the role of XMRV (and related murine retroviruses) in human disease. Note in particular his statement “While the major XMRV studies to date appear to be well controlled for these problems, extreme caution is necessary”.


]]> http://www.virology.ws/2010/10/02/why-john-coffin-doesnt-sleep-well/feed/ 21 CFS,chronic fatigue syndrome,john coffin,viral,virology,virus,xmrv John Coffin, Professor of Genetics and Molecular Microbiology at Tufts University, studies the molecular biology and evolution of retroviruses. He wrote a commentary (A new virus for old diseases?) that accompanied the publication by Lombardi and colle... John Coffin, Professor of Genetics and Molecular Microbiology at Tufts University, studies the molecular biology and evolution of retroviruses. He wrote a commentary (A new virus for old diseases?) that accompanied the publication by Lombardi and colleagues of the finding of the new retrovirus XMRV in patients with chronic fatigue syndrome, and has spoken widely about whether this virus has a causative role in the disease. In this video he expresses cautious optimism about the role of XMRV (and related murine retroviruses) in human disease. Note in particular his statement "While the major XMRV studies to date appear to be well controlled for these problems, extreme caution is necessary". virology blog no TWiV 100: TWiV catches a big fish http://www.virology.ws/2010/09/26/twiv-100-twiv-catches-a-big-fish/ http://www.virology.ws/2010/09/26/twiv-100-twiv-catches-a-big-fish/#comments Sun, 26 Sep 2010 16:27:25 +0000 Vincent Racaniello http://www.virology.ws/?p=3448

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and David Baltimore

Vincent, Alan, and Rich celebrate the 100th episode of the podcast This Week in Virology by talking about viruses with Nobel Laureate David Baltimore.

Click the arrow above to play, or right-click to download TWiV #100 (68 MB .mp3, 94 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Alan – TimeTree
Rich – The neurons that shaped civilization
Vincent – Ahead of the Curve: David Baltimore’s Life in Science by Shane Crotty

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/09/26/twiv-100-twiv-catches-a-big-fish/feed/ 3 asilomar,david baltimore,mengovirus,nobel,podcast,poliovirus,polymerase,racaniello,recombinant dna,retrovirus,reverse transcriptase,rna synthesis Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and David Baltimore Vincent, Alan, and Rich celebrate the 100th episode of the podcast This Week in Virology by talking about viruses with Nobel Laureate David Baltimore. - Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and David Baltimore Vincent, Alan, and Rich celebrate the 100th episode of the podcast This Week in Virology by talking about viruses with Nobel Laureate David Baltimore. Click the arrow above to play, or right-click to download TWiV #100 (68 MB .mp3, 94 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: David's early papers on poliovirus and mengovirus RNA synthesis Reverse transcriptase found by Baltimore and Temin (pdfs) Nobel Prize in Physiology or Medicine 1975 David fishing (Picasa web album) The David Baltimore asteroid belt Cedric's essay The 'Death' of a Virus (pdf) Letters read on TWiV 100 Weekly Science Picks Alan - TimeTree Rich - The neurons that shaped civilization Vincent - Ahead of the Curve: David Baltimore's Life in Science by Shane Crotty Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 99: ICAAC Boston 2010 http://www.virology.ws/2010/09/19/twiv-99-icaac-boston-2010/ http://www.virology.ws/2010/09/19/twiv-99-icaac-boston-2010/#comments Mon, 20 Sep 2010 02:58:30 +0000 Vincent Racaniello http://www.virology.ws/?p=3429

Host: Vincent Racaniello

Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Boston, speaking with exhibitors and visitors, including Professors Derek Smith, Michael Schmidt, Frederick Hayden, and Myra McClure.

Many thanks to Chris Condayan and Ray Ortega of the American Society for Microbiology for recording and editing this episode.

Click the arrow above to play, or right-click to download TWiV #99 (45 MB .mp3, 62 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/09/19/twiv-99-icaac-boston-2010/feed/ 9 antigenic cartography,antigenic drift,antiviral,bacteria,CFS,chronic fatigue syndrome,conference,copper,icaac,influenza,pandemic,podcast Host: Vincent Racaniello - Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Boston, speaking with exhibitors and visitors, including Professors Derek Smith, Michael Schmidt, Frederick Hayden, Host: Vincent Racaniello Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Boston, speaking with exhibitors and visitors, including Professors Derek Smith, Michael Schmidt, Frederick Hayden, and Myra McClure. Many thanks to Chris Condayan and Ray Ortega of the American Society for Microbiology for recording and editing this episode. Click the arrow above to play, or right-click to download TWiV #99 (45 MB .mp3, 62 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: 50th ICAAC ICAAC daily press conference videos (including Prof. Myra McClure) Antigenic cartography Antimicrobial properties of copper Video of this episode – download .mp4 (1.99 GB) or .wmv (935 MB) or view below Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 98: Murine musings, electric shirts, and rabid pathologists http://www.virology.ws/2010/09/12/twiv-98-murine-musings-electric-shirts-and-rabid-pathologists/ http://www.virology.ws/2010/09/12/twiv-98-murine-musings-electric-shirts-and-rabid-pathologists/#comments Mon, 13 Sep 2010 00:50:15 +0000 Vincent Racaniello http://www.virology.ws/?p=3426

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

On episode 98 of the podcast This Week in Virology, Vincent, Alan, and Rich review the finding of murine leukemia virus-related sequences in the blood of CFS patients and healthy donors, laboratory inventories for wild poliovirus containment, weaving high-performance viral batteries into fabric for the military, and a case of human rabies in Indiana.

Click the arrow above to play, or right-click to download TWiV #98 (58 MB .mp3, 80 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Alan – NCBI ROFL
Rich – The Great Bridge by David McCullough
Vincent – Dr. Rous’ Prize-Winning Chicken

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/09/12/twiv-98-murine-musings-electric-shirts-and-rabid-pathologists/feed/ 0 bacteriophage,CFS,chronic fatigue syndrome,condit,dove,M13,mlv,murine leukemia virus,pmrv,podcast,poliovirus,rabies Hosts: Vincent Racaniello, Alan Dove, and Rich Condit - On episode 98 of the podcast This Week in Virology, Vincent, Alan, and Rich review the finding of murine leukemia virus-related sequences in the blood of CFS patients and healthy donors, Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode 98 of the podcast This Week in Virology, Vincent, Alan, and Rich review the finding of murine leukemia virus-related sequences in the blood of CFS patients and healthy donors, laboratory inventories for wild poliovirus containment, weaving high-performance viral batteries into fabric for the military, and a case of human rabies in Indiana. Click the arrow above to play, or right-click to download TWiV #98 (58 MB .mp3, 80 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: MLV-related sequences in blood of CFS patients (commentary) Laboratory inventories for poliovirus containment Viral batteries for the military (abstract) - also see TWiV 28 Human rabies, Kentucky/Indiana, 2009 Letters read on TWiV 98 Weekly Science Picks Alan - NCBI ROFL Rich - The Great Bridge by David McCullough Vincent - Dr. Rous' Prize-Winning Chicken Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 97: California virology http://www.virology.ws/2010/09/05/twiv-97-california-virology/ http://www.virology.ws/2010/09/05/twiv-97-california-virology/#comments Sun, 05 Sep 2010 22:18:41 +0000 Vincent Racaniello http://www.virology.ws/?p=3387

Hosts: Vincent Racaniello, Peter Sarnow, and Bert Semler

On episode #97 of the podcast This Week in Virology, Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication.

Click the arrow above to play, or right-click to download TWiV #97 (66 MB .mp3, 91 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

  • Eukaryotic mRNAs that might contain an IRES (PNAS)
  • Modulation of HCV RNA abundance by a liver-specific microRNA (Science)
  • Viral small RNAs (PLoS Pathogens)
  • Bridging IRES elements to the translation apparatus (Biochim Biophys Acta)
  • A nucleo-cytoplasmic SR protein functions in viral IRES mediated translation (EMBO J)
  • Nuclear vs cytoplasmic routes to IRES mediated translation (Trends in Microbiology)
  • Letter read on TWiV 97

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/09/05/twiv-97-california-virology/feed/ 9 HCV,hepatitis C virus,internal ribosome binding,IRES,microrna,mIR-122,picornavirus,poliovirus,translation,viral,virology,virus Hosts: Vincent Racaniello, Peter Sarnow, and Bert Semler On episode #97 of the podcast This Week in Virology, Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, Hosts: Vincent Racaniello, Peter Sarnow, and Bert Semler On episode #97 of the podcast This Week in Virology, Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication. Click the arrow above to play, or right-click to download TWiV #97 (66 MB .mp3, 91 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Eukaryotic mRNAs that might contain an IRES (PNAS) Modulation of HCV RNA abundance by a liver-specific microRNA (Science) Viral small RNAs (PLoS Pathogens) Bridging IRES elements to the translation apparatus (Biochim Biophys Acta) A nucleo-cytoplasmic SR protein functions in viral IRES mediated translation (EMBO J) Nuclear vs cytoplasmic routes to IRES mediated translation (Trends in Microbiology) Letter read on TWiV 97 Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 96: Making viral DNA http://www.virology.ws/2010/08/22/twiv-96-making-viral-dna/ http://www.virology.ws/2010/08/22/twiv-96-making-viral-dna/#comments Sun, 22 Aug 2010 15:46:21 +0000 Vincent Racaniello http://www.virology.ws/?p=3385

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

On episode #96 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a discussion of how viruses with DNA genomes replicate their genetic information.

Click the arrow above to play, or right-click to download TWiV #96 (65 MB .mp3, 90 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:


Weekly Science Picks

Rich – Breast milk sugars give infants a protective coat (NY Times and PNAS article)
 Vincent – The Great American University by Jonathan R. Cole

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/08/22/twiv-96-making-viral-dna/feed/ 0 DNA,double helix,genome,lagging strand,leading strand,parvovirus,podcast,polyomavirus,primer,replication,SV40,viral Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit On episode #96 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a discussion of how viruses with DNA genomes replicate their genetic information. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit On episode #96 of the podcast This Week in Virology, Vincent, Dickson, and Rich continue Virology 101 with a discussion of how viruses with DNA genomes replicate their genetic information. Click the arrow above to play, or right-click to download TWiV #96 (65 MB .mp3, 90 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Figures for this episode (pdf) RNA silencing as a plant immune system (Trends in Genetics) Photos of transgenic petunia (PLoS Biology) Letters read on TWiV 96 Video of this episode - download .mov or .wmv or view below Weekly Science Picks Rich - Breast milk sugars give infants a protective coat (NY Times and PNAS article) Vincent - The Great American University by Jonathan R. Cole Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 95: Does a virus shift in the woods? http://www.virology.ws/2010/08/15/twiv-95-does-a-virus-shift-in-the-woods/ http://www.virology.ws/2010/08/15/twiv-95-does-a-virus-shift-in-the-woods/#comments Sun, 15 Aug 2010 23:40:44 +0000 Vincent Racaniello http://www.virology.ws/?p=3382

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

On episode #95 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, vaccinia virus infection in Brazilian monkeys, and viruses in the faecal microbiota.

Click the arrow above to play, or right-click to download TWiV #95 (68 MB .mp3, 94 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Alan – Families Fighting Flu
Rich – Food, Inc.
Dickson –  Fuel
Vincent – MIT Open Courseware
Michael –  Waiting for Superman and Can Science Feed the World? (Nature)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/08/15/twiv-95-does-a-virus-shift-in-the-woods/feed/ 1 bacteriophage,Brazil,Dengue,fecal,H1N1,influenza,microbiota,pandemic,podcast,swine flu,vaccinia,viral Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #95 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit On episode #95 of the podcast This Week in Virology, Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, vaccinia virus infection in Brazilian monkeys, and viruses in the faecal microbiota. Click the arrow above to play, or right-click to download TWiV #95 (68 MB .mp3, 94 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: WHO declares end of influenza H1N1 pandemic CDC's FluView WHO global monitoring of influenza Locally acquired dengue in Key West, Florida (MMWR) CDC page on dengue Vaccinia virus infection in monkeys of the Brazilian Amazon Dam site where animals were collected for vaccinia study (Google maps) Rich's article: Whence feral vaccinia? Viruses in the faecal microbiota of monozygotic twins and their Mothers (Nature) New Yorker article The Treatment (thanks, Jim!) Letters read on TWiV 95 Weekly Science Picks Alan - Families Fighting Flu Rich - Food, Inc. Dickson -  Fuel Vincent - MIT Open Courseware Michael -  Waiting for Superman and Can Science Feed the World? (Nature) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiP 14: Leishmania http://www.virology.ws/2010/08/11/twip-14-leishmania/ http://www.virology.ws/2010/08/11/twip-14-leishmania/#comments Thu, 12 Aug 2010 02:49:28 +0000 Vincent Racaniello http://www.virology.ws/?p=3367

Hosts: Vincent Racaniello and Dickson Despommier

On episode 14 of the podcast This Week in Parasitism, Vincent and Dickson consider the life cycle and pathogenesis of the protozoan parasite Leishmania.

Click the arrow above to play, or right-click to download

TWiP is brought to you by the American Society for Microbiology at Microbeworld.org.

Links for this episode:

Download TWiP #14 (61 MB .mp3, 85 minutes)

Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email

Send your questions and comments to twip@twiv.tv

]]> http://www.virology.ws/2010/08/11/twip-14-leishmania/feed/ 0 amastigote,kala-azar,leishmania,life cycle,parasite,parasitic,parasitism,promastigote,sandfly,twip Hosts: Vincent Racaniello and Dickson Despommier On episode 14 of the podcast This Week in Parasitism, Vincent and Dickson consider the life cycle and pathogenesis of the protozoan parasite Leishmania. - Click the arrow above to play, Hosts: Vincent Racaniello and Dickson Despommier On episode 14 of the podcast This Week in Parasitism, Vincent and Dickson consider the life cycle and pathogenesis of the protozoan parasite Leishmania. Click the arrow above to play, or right-click to download TWiP is brought to you by the American Society for Microbiology at Microbeworld.org. Links for this episode: L. braziliensis life cycle (jpg) L. donovani life cycle (jpg) L. tropica life cycle (jpg) L. major lesion (jpg) Transgenic mosquito delivers Leishmania vaccine (thanks, Geoffrey) Plasmodium falciparum accompanied human expansion out of Africa (thanks, Prasad) Who speaks for the guinea worm? (thanks, Michael) Letters read on TWiP 14 Download TWiP #14 (61 MB .mp3, 85 minutes) Subscribe to TWiP (free) in iTunes, at the Zune Marketplace, by the RSS feed or by email Send your questions and comments to twip@twiv.tv virology blog no TWiV 94: XMRV with Dr. Ila Singh http://www.virology.ws/2010/08/08/twiv-94-xmrv-with-dr-ila-singh/ http://www.virology.ws/2010/08/08/twiv-94-xmrv-with-dr-ila-singh/#comments Sun, 08 Aug 2010 12:24:14 +0000 Vincent Racaniello http://www.virology.ws/?p=3349

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Ila Singh

On episode #94 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome.

Click the arrow above to play, or right-click to download TWiV #94 (56 MB .mp3, 77 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Alan – The new Federal Register site (see also regulations.gov)
Rich – The Florida Museum of Nautural History Butterfly Rainforest
Vincent – JoVE, the Journal of Visualized Experiments

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/08/08/twiv-94-xmrv-with-dr-ila-singh/feed/ 2 CFS,chronic fatigue syndrome,ila singh,prostate cancer,retrovirus,viral,virology,virus,xmrv Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Ila Singh On episode #94 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association... Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Ila Singh On episode #94 of the podcast This Week in Virology, Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome. Click the arrow above to play, or right-click to download TWiV #94 (56 MB .mp3, 77 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: CFIDS Association of America Discovery of XMRV (PLoS Pathogens) Detection of XMRV in CFS patients (Science) Presence of XMRV in malignant prostate (PNAS) Inhibition of XMRV by raltegravir (PLoS One) Letters read on TWiV 94 Weekly Science Picks Alan - The new Federal Register site (see also regulations.gov) Rich - The Florida Museum of Nautural History Butterfly Rainforest Vincent - JoVE, the Journal of Visualized Experiments Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 93: Our infectious inbox http://www.virology.ws/2010/08/01/twiv-93-our-infectious-inbox/ http://www.virology.ws/2010/08/01/twiv-93-our-infectious-inbox/#comments Sun, 01 Aug 2010 14:25:48 +0000 Vincent Racaniello http://www.virology.ws/?p=3325

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

On episode #93 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about lab procedures, prokaryotes, endogenous retroviruses, the iPad and teaching, prions, mimivirus, splitting water with viruses, and the polio outbreak in Tajikistan.

Click the arrow above to play, or right-click to download TWiV #93 (76 MB .mp3, 105 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Alan – Southern Fried Science
Rich – Tree of Life web project
Vincent – Dickson Despommier at Big Think

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/08/01/twiv-93-our-infectious-inbox/feed/ 1 ERV,ipad,laboratory,mimivirus,phd,polio,poliovirus,prion,prokaryote,retrovirus,takikistan,viral Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #93 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about lab procedures, prokaryotes, endogenous retroviruses, the iPad and teaching, prions, Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #93 of the podcast This Week in Virology, Vincent, Alan, and Rich answer listener questions about lab procedures, prokaryotes, endogenous retroviruses, the iPad and teaching, prions, mimivirus, splitting water with viruses, and the polio outbreak in Tajikistan. Click the arrow above to play, or right-click to download TWiV #93 (76 MB .mp3, 105 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Biomedical Advanced Research and Development Authority (BARDA) SIGA responds to BARDA request for smallpox antiviral BARDA contract for filovirus vaccine What is a Ph.D? (pdf) HHMI resources for early career scientists Pace article on abandoning prokaryote (Nature) Three domains of life (Forterre article) Mechanoenzymatic cleavage of Von Willebrand's factor (Science) Splitting water with viruses WHO coverage on Tajikstan polio outbreak Wild type polio infection in immunized Indian children (JID) Letters read on TWiV 93 Weekly Science Picks Alan - Southern Fried Science Rich - Tree of Life web project Vincent - Dickson Despommier at Big Think Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no TWiV 92: Live at ASV in Bozeman http://www.virology.ws/2010/07/25/twiv-92-live-at-asv-in-bozeman/ http://www.virology.ws/2010/07/25/twiv-92-live-at-asv-in-bozeman/#comments Sun, 25 Jul 2010 15:12:33 +0000 Vincent Racaniello http://www.virology.ws/?p=3313

Hosts: Vincent Racaniello, Rich Condit, Karla Kirkegaard, and Marilyn Roosinck

On episode #92 of the podcast This Week in Virology, Vincent, Rich, Karla, and Marilyn recorded TWiV at the 29th Annual Meeting of the American Society for Virology in Bozeman, where they discussed plant viruses and how they make plants resistant to adverse conditions, and identification of dominant negative drug targets.

Click the arrow above to play, or right-click to download TWiV #92 (42 MB .mp3, 57 minutes)

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio.

Links for this episode:

Weekly Science Picks

Marilyn – Viruses in the faecal microbiota of monozygotic twins and their mothers (Nature)
Rich – The Known Universe by the American Museum of Natural History
Vincent – The Red Queen by Matt Ridley (thanks, Jesper!)

Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

]]> http://www.virology.ws/2010/07/25/twiv-92-live-at-asv-in-bozeman/feed/ 1 AIDS,antiviral,asv,bozeman,HIV,mutualism,plant virus,polio,poliovirus,symbiosis,tmv,viral Hosts: Vincent Racaniello, Rich Condit, Karla Kirkegaard, and Marilyn Roosinck On episode #92 of the podcast This Week in Virology, Vincent, Rich, Karla, and Marilyn recorded TWiV at the 29th Annual Meeting of the American Society for Virology in Boze... Hosts: Vincent Racaniello, Rich Condit, Karla Kirkegaard, and Marilyn Roosinck On episode #92 of the podcast This Week in Virology, Vincent, Rich, Karla, and Marilyn recorded TWiV at the 29th Annual Meeting of the American Society for Virology in Bozeman, where they discussed plant viruses and how they make plants resistant to adverse conditions, and identification of dominant negative drug targets. Click the arrow above to play, or right-click to download TWiV #92 (42 MB .mp3, 57 minutes) Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, or by email, or listen on your mobile device with Stitcher Radio. Links for this episode: Lifestyles of plant viruses Using pyrosequencing to understand virus ecology A virus in a fungus in a plant Trans-dominant inhibition of RNA viral replication Resistance is futile Announcement of TWiV at ASV (pdf) Photographs of TWiV at ASV Letters read on TWiV 92 Weekly Science Picks Marilyn - Viruses in the faecal microbiota of monozygotic twins and their mothers (Nature) Rich - The Known Universe by the American Museum of Natural History Vincent - The Red Queen by Matt Ridley (thanks, Jesper!) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv or leave voicemail at Skype: twivpodcast. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv. virology blog no