AFP surveillance in Pakistan

AFP surveillance in Pakistan. Image credit.

In early June it was widely reported that the first case of poliomyelitis in 30 years had been identified in Venezuela (see this Tech Times report as an example). Fortunately these reports were incorrect, and Venezuela remains free of polio. Let’s unpack exactly what happened.

[click to continue…]

By David Tuller, DrPH

This morning, Professor Racaniello sent the following e-mail to Richard Horton, editor of The Lancet. The subject heading: “Another open letter about the PACE trial.” He cc’d the three lead PACE investigators and the public relations office at Queen Mary University of London. Virology Blog’s previous open letter to The Lancet about the PACE trial was sent and posted in February, 2016.

[click to continue…]

By David Tuller, DrPH

Update: 6/26/18

When I wrote last week in the post below about Mike Godwin’s intervention into the PACE debate, I mentioned that “a PACE critic” triggered the events by tweeting a reference to “the banality of evil”—the famous Hannah Arendt phrase that emerged out of her coverage of the trial of Eichmann in Jerusalem. For more on the tweeter’s academic and professional background and on the context of the Arendt reference, please see the update at the end of the post.

**********

[click to continue…]

This morning I sent the following e-mail to key NICE executives involved in the effort to overhaul the clinical guidance for ME/CFS. I cc’d several stakeholders in the process as well.

**********

[click to continue…]

Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research.

Click arrow to play
Download TWiV 498 (42 MB .mp3, 68 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

IFN signaling

Type I IFN receptor binding and signal transduction.

By Gertrud U. Rey

Zika virus (ZIKV) infection causes microcephaly in newborns and is causally associated with Guillian–Barré syndrome in adults. To date, there are no drugs available to prevent or treat ZIKV infection. ZIKV vaccine research is challenging because adult immunocompetent mice are resistant to ZIKV infection and disease.

[click to continue…]

By David Tuller, DrPH

Ten years ago, the National Health Service began rolling out across England a program called Improving Access to Psychological Therapies, or IAPT. This program arose out of the notion that many people were suffering from untreated depression, anxiety and other psychiatric disorders. In parallel with that, research suggested that treating these ailments would not only be good for public health but would in turn help restrain overall medical costs. The most common but not the only psychotherapeutic intervention offered by IAPT services is cognitive behavior therapy.

[click to continue…]

By David Tuller, DrPH

This morning I sent three more e-mails alerting interested parties to my concerns about two BMJ studies of children with ME/CFS. When it comes to research, kids are already a vulnerable population, and those with a stigmatizing illness even more so. That’s why it is both surprising and troubling that BMJ appears to have little interest in addressing the ethical and/or methodological violations that Virology Blog has documented in these pediatric studies.

[click to continue…]

TWiV 497: Europic 2018

At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research.

Click arrow to play
Download TWiV 497 (36 MB .mp3, 60 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

N-terminal myristoylation

N-terminal myristoylation. An amide bond links myristate to an N-terminal glycine in the myristoylation site consensus sequence.

The common cold is an infection of the upper respiratory tract that may be caused by many different viruses, but most frequently by rhinoviruses. A compound that inhibits a cell enzyme and blocks rhinovirus replication has the potential to be developed into an antiviral drug (link to paper).

[click to continue…]