Paul Has Measles is a children's book about viruses and vaccines available in English (download link) Spanish (download link) French (download link) and German (download link).

By David Tuller, DrPH

In addition to giving a couple of talks in Norway, I also answered some questions from Trude Schei, assistant Secretary General of the Norwegian ME Association. I doubt I said anything I haven’t stated many times before.

However, members of the GET/CBT ideological brigades–in Norway and elsewhere–continue to maintain against all the evidence that their science is robust. Therefore, it cannot be repeated often enough that the PACE trial is a piece of crap and that other studies in this field–including the Cochrane systematic reviews–are also problematic and unreliable.

Trude has now posted the interview. Here’s the link:

https://www.facebook.com/MEforeningen/videos/283606169175397/

The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice.

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Zika virusIntestinal dysmotility disorders such as irritable bowel syndrome affect 10-30% of humans in Western countries. Some of these diseases appear to correlate with viral infection. Inoculation of mice with neurotropic flaviviruses leads to injury and death of enteric neurons, inflammation, intestinal dilation and retarded bowel transit, providing a model for studying and treating these human intestinal disorders. [continue reading…]

By David Tuller, DrPH

Earlier this month, NIH director Francis Collins and other agency officials held a meeting with five representatives from #MEAction. According to the group’s post about the meeting, the goal was “to discuss accelerating research in order to more rapidly provide diagnostics and treatments to people with ME.” Specifically, #MEAction urged the agency to develop “bold leadership for ME,” “disease-specific, multi-year Request for Application (RFAs) and investigator-initiated funding opportunities,” and “a strategic plan: comprehensive, fully-funded, cross-Institute and outcome-driven.”

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By David Tuller, DrPH

In an eagerly awaited draft report, an Australian advisory committee on ME/CFS has called for the development of up-to-date domestic clinical guidelines and an increase in biomedical research into the pathophysiology of the illness. The draft report, which could have a major impact on health policy going forward, also highlights the potentially dangerous impacts of graded exercise therapy, the international controversy over the PACE trial and the challenges that Australian patients confront accessing federal disability benefits.

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The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses.

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These Bacteria are Bugged

bacteriophage modelBy Gertrud U. Rey

Quorum sensing is a form of cell to cell communication in bacteria in which individual cells coordinate their behavior based on population density. In human terms, the word “quorum” means “the minimum number of people required to conduct business.”

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By David Tuller, DrPH

I haven’t had time to cover the new and wildly over-hyped study about prolonged fatigue–and purportedly about “chronic fatigue syndrome”–that was published this week in the journal Psychoneuroendocrinology. Thanks no doubt to the involvement of the Science Media Centre, this mildly interesting piece of research has received widespread media attention.

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Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel’s Autism.

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Show notes at microbe.tv/twiv

rhinovirus 16When a human population is exposed to a pathogenic virus, the outcomes among individuals may include asymptomatic, mild, severe, or no infection. Multiple parameters control these responses, including the amount of virus taken up, the age of the host, general health status, nutrition, and more. With the advent of whole exome sequencing we can now assess the role of genotype in disease severity, as illustrated by a study of a child with severe recurrent rhinovirus infections.

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