TWiV 579: Reno viral

Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases.

Click arrow to play
Download TWiV 579 (61 MB .mp3, 101 min)
Subscribe (free): iTunesGoogle PodcastsRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

Comments on this entry are closed.

  • Rishat RR Ahmetvaleev 23 December 2019, 2:25 am

    I Rakhat Rafailievich Akhmetvaleev have been proving my immunity for many years. Now my immunity is proven on the Internet. Thus, the activity of the immune system depends on a number of factors: Gastrointestinal tract health (hereinafter GIT). I eat 5 times a day. Almost every day I go to the bathroom mostly.
    Toxic load on the body. I live in the Almetyevsk oil capital of Tatarstan
    Stability of the nervous system. Since childhood, I do not work as a disabled person of 2 groups. I sleep 8 hours. Calm At home
    cat lives, constantly stroking her
    The quality of food. . Thanks to my mother, the quality of food is excellent. Mom is an old-age pensioner by profession a cook .. I eat milk porridge every day and drink 100% coffee every day. I eat or drink dairy products almost every day. I eat vegetables and fruits every day. I drink tea with lemon every day and squeeze lemon into tea and eat lemon.
      The result of the analysis made in the Almetyevsk AIDS center of lymphocytes is 55% with a norm of 11 to 37%. The result of the analysis of the outpatient clinic of PJSC Tatneft is 49%. In the 2nd immunogram, the local immunologist wrote lymphocytosis as a result of the activity of t-cells. Types of T-lymphocytes
    T-cell receptors are the main surface protein complexes of T-lymphocytes responsible for the recognition of processed antigens associated with the molecules of the main histocompatibility complex (MHC) on the surface of antigen-presenting cells [2]. The T cell receptor is linked to another polypeptide membrane complex, CD3. The functions of the CD3 complex include signaling into the cell, as well as stabilization of the T-cell receptor on the membrane surface. A T cell receptor can be associated with other surface proteins, its coreceptors. Depending on the coreceptor and the functions performed, two main types of T cells are distinguished.

    T-helpers

    Antigen-recognizing receptor complex of T-helpers
    T-helpers (from the English. Helper – assistant) – T-lymphocytes, the main function of which is to strengthen the adaptive immune response. They activate T-killers, B-lymphocytes, monocytes, NK cells in direct contact, as well as humorally, releasing cytokines. The main sign of T-helpers is the presence of a CD4 coreceptor molecule on the cell surface. T-helpers recognize antigens by the interaction of their T-cell receptor with an antigen bound to the molecules of the main histocompatibility complex of class II (Eng. Major Histocompatibility Complex II (MHC-II)).

    T-killers
    Main article: Cytotoxic T lymphocytes
    T-killers, cytotoxic T-lymphocytes, CTL (from the English killer “killer”) – T-lymphocytes, the main function of which is the destruction of damaged cells of their own body. T-killer targets are cells affected by intracellular parasites (which include viruses and some types of bacteria), tumor cells. T-killers are a major component of antiviral immunity. The main sign of T-killers is the presence of a CD8 coreceptor molecule on the cell surface. T-killers recognize antigens by the interaction of their T-cell receptor with an antigen associated with the molecules of the main histocompatibility complex class I (English Major Histocompatibility Complex I (MHC-I)).

    T-helpers and T-killers form a group of effector T-lymphocytes directly responsible for the immune response. At the same time, there is another group of cells, regulatory T-lymphocytes, whose function is to regulate the activity of effector T-lymphocytes. By modulating the strength and duration of the immune response through the regulation of T-effector cell activity, regulatory T-cells maintain tolerance to the body’s own antigens and prevent the development of autoimmune diseases. There are several suppression mechanisms: direct, with direct contact between cells, and distant, carried out at a distance – for example, through soluble cytokines.

     T-killers, cytotoxic T-lymphocytes, CTL (English killer “killer”) – a type of T-lymphocytes that performs the lysis of damaged cells of their own body. T-killer targets are cells affected by intracellular parasites (which include viruses and some types of bacteria), tumor cells. T-killers are a major component of antiviral immunity.
     You can make a vaccine in a few days from my immunoglobulin. And part of the immunoglobulin is artificially copied. I propose to make a vaccine based on my immunity. We must start now so that it is not too late.
     A disabled person of 2 groups since childhood on 2 rare internal incurable diseases, 38 years old I take medicine 3 times a day