Trial By Error: More Calls to Godlee for LP Study Retraction

By David Tuller, DrPH

Last last month, I resent Dr Fiona Godlee a letter criticizing BMJ’s decision to republish the Lightning Process study with the same findings. The first iteration, in July, was signed by 55 scientists, clinicians and other experts. This version was signed by more than 70 experts and over 60 patient and advocacy organizations. After I sent the previous version, more than a dozen of the signatories followed up with letters of their own to Dr Godlee.

Below are two more recent ones. The first is from my Berkeley colleague, infectious disease professor emeritus John Swartzberg, who is also editorial director of the Berkeley Wellness Letter and BerkeleyWellness.com. The second is from Dr Susan Taylor-Brown, a retired pediatrician at Golisano Children’s Hospital at the University of Rochester.

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Dear Dr. Godlee,

Thank you for your efforts in maintaining the high quality of the BMJ.  I am a professor in the School of Public Health at the University of California, Berkeley.  As editor of the UC Berkeley Health and Wellness Publications, I appreciate how difficult it is to uphold the highest standards of journalistic integrity.

I do think the BMJ seriously slipped when it decided not to retract the article “Clinical and Cost-Effectiveness of the Lightning Process.”  The following is a partial list of some of my concerns:  It was not a randomized controlled trial as the authors stated; protocols are portrayed as predesignated but in fact were not since they were swapped midway through the study; there was poor participation for questionnaire participation; and the research was conducted in such a way as to increase confirmation bias.

While the above reasons are sufficient to retract this paper, I believe the strongest reason is that it harms the very children it claims to help.  Its reported findings have the potential to cause severe damage to young ME/CFS patients.  It can give false hope and potentially cause patients to have a serious relapse.

I urge you to retract this damaged and damaging paper.

John Swartzberg, MD, FACP

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Dear Dr. Godlee:

I am writing to address the “Correction” published in Archives of Disease in Childhood and urge you to consider retracting this publicationChildren are a protected class of research subjects. The Lightning Process article failed to adhere to the principle of protecting vulnerable children who are diagnosed with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).  There is growing evidence that ME/CFS is a neuro immune disorder that has significant impact on a person’s ability to function (Freidberg, Sunnquist & Nacul, 2019,  Institute of Medicine, 2015); not a psychosomatic illness as assumed by the Lightning Process authors.

Since the early 1990s, multiple studies have compared patients with ME/CFS with healthy age- and sex-matched controls and found abnormalities of the central and autonomic nervous system (Komaroff & Cho, 2011). An analysis of large international patient surveys (Kindlon, 2011) found that over 50% of patients reported that CBT and GET not only fell short of delivering significant improvements but often let to worsened health due to ill-advised activity and exercise prescriptions. Blease, Carel, & Geraghty (2017) note that the failure to address these negative outcomes appears to be the result of skepticism of ME/CFS. Experienced clinicians do not recommend PACE-type GET or CBT as treatments (Friedberg, Bateman, Bested, Friedman, Gurwitt, Lapp, & Vallings, 2012).

It is unfortunate that the authors of the Lightning article addressed the Lightning Process correction rather than an independent panel of ME/CFS experts. This study appears to be the contemporary example of a poorly designed, unethical research study that fails to protect pediatric subjects. This study will be used as an exemplar of poorly designed and implemented research. As researchers, we are to do no harm; the Lightning Process fails to protect children and must be retracted.

Sincerely,

Susan Taylor-Brown, PhD

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Blease C, Carel H, Geraghty K. Epistemic injustice in healthcare encounters: evidence from chronic fatigue syndrome. J Med Ethics. 2017;43(8)549–557.

Friedberg, F., Sunnquist, M, and Nacul, L. Rethinking the Standard for Care of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Gen intern Med (2019)

Friedberg F, Bateman L, Bested AC, Friedman KJ, Gurwitt A, Lapp CW, Vallings R. ME/CFS: A primer for clinical practitioners. Chicago: International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. 2012.

Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. Washington, DC: National Academies Press; 2015.

Kindlon T. Reporting of harms associated with graded exercise therapy and cognitive behavioural therapy in myalgic encephalomyelitis/chronic fatigue syndrome. Bull the IACFS/ME. 2011;19(2)59–111. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. Washington (DC): National Academies Press (US); 2015 Feb.

 

{ 4 comments… add one }
  • CT 2 December 2019, 8:26 pm

    ‘Too Much Quackery’ and ‘Not Enough Medicine’, I’d say. The longer this drags on, the worse it looks for the BMJ.

  • Alicia Butcher Ehrhardt 3 December 2019, 5:20 am

    Their name is mud already. It’s not going to get better. And the longer they keep up the farce, the harder it will be to save whatever face they have left.

    The letter from Dr. Swartzberg is beautifully concise.

  • CT 3 December 2019, 6:07 am

    The BMJ turned a soundbite -‘Too Much Medicine’ – into a far-reaching campaign objective that seemingly finds them content to leave sick kids standing in circles shouting ‘stop’ at their debilitating symptoms rather than receiving good medical care. In my opinion they lost the plot, Godlee lost the plot, and she needs to act fast to try to reverse the damage.

    This ‘too much medicine’ soundbite is dangerous, because the only thing it’s certain to do is reduce healthcare spending. I’m sure there are tests and treatments that aren’t helpful and may be harmful, that need weeding out by listening to doctors AND patients, but the intense focus on the iatrogenic harm of ‘bio’/physical medicine for the sake of saving money has left many patients excluded from the biomedical care that they desperately need. It’s a bit late in the day for Godlee to start back-pedalling, but back-pedal she must, and fast. It appears that she may have paused for thought -https://www.bmj.com/content/364/bmj.l902 – as she writes here -“individual judgment will always be needed” – but is that advice 14 years too late? Let’s hope she uses some individual judgment now, sees the error of her ways, and retracts this appallingly bad study without delay.

  • jimells 3 December 2019, 2:15 pm

    Dr Taylor-Brown,
    Thank you for your strongly worded rebuke of the LP study. Plain spoken public statements will be very important evidence when the Wessely School associates are finally held to account in a court of law.

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