June 2014

Implications of finding poliovirus in sewers of Brazil and Israel

Wild poliovirus has been detected in the sewers of Brazil and Israel. Fortunately, no cases of poliomyelitis have been reported in either country. Why is poliovirus present in these countries and what are the implications for the eradication effort? Wild type poliovirus (e.g. not vaccine-derived virus) was detected in sewage samples that had been collected …

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Reconstruction of 1918-like avian influenza virus stirs concern over gain of function experiments

The gain of function experiments in which avian influenza H5N1 virus was provided the ability to transmit by aerosol among ferrets were met with substantial outrage from both the press and even some scientists; scenarios of lethal viruses escaping from the laboratory and killing millions proliferated (see examples here and here). The recent publication of …

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Origin of segmented RNA virus genomes

Segmented genomes abound in the RNA virus world. They are found in virus particles from different families, and can be double stranded (Reoviridae) or single stranded of (+) (Closteroviridae) or (-) (Orthomyxoviridae) polarity. Our recent discussion of the advantages of a segmented viral genome, compared with monopartitie genomes, generated a good discussion. Another interesting question concerns the evolutionary relationship between the two …

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