Is it Ebolavirus or Ebola virus?

Hi Pr. Racaniello,

A few months ago I was struggling with the taxonomy of viruses while writing my
PhD thesis since I didn’t want to be inaccurate or make sloppy mistakes in what
was supposed to be the “culminating point” of my training. Back then
I didn’t realize there was such an increasing discrepancy (that I was
contributing to incidentally) as to the terminology of viral taxonomy.

Since I read the piece of Kuhn and Jahrling (Clarification & guidance on
the proper usage of virus and virus species names), I think that I finally use
the terminology related to virus & virus species names much more
appropriately than I did before.

Now that I have understood that I shouldn’t use the name of a species – which
is a taxon and therefore a “concept” – to describe those properties
that should only be assigned to virions, I am much more careful. A great
reminder for me is that taxa are created and can change over time but that virions
are “tangible”, they are what they are and them only can be actually
characterized (For instance, I used to say that a certain viral species was
known to infect a certain host. Now I try to be more specific by saying that
the virions belonging/assigned to this very species are what actually infects
cells, not the taxon).

The example given by Kuhn and Jahrling is kinda funny but helped me a lot: they
say that we intuitively understand that a standard poodle and a German shepherd
are very different although both being “domestic dogs”, meaning they
both belong to the species Canis lupus
familiaris. They explain that a standard poodle and a German
shepherd are related enough on several levels (including genomic) to be grouped
in a taxonomic class as low as the species BUT that it is also way obvious that
both of them can still be easily discriminated based on many other factors
(including genomic as well). So basically, they recommend thinking of virus and
virus species names the same way.

However, I can’t help finding that being accurate with virus and virus species
names is a little less intuitive than it is with dog breeds and the species Canis lupus familiaris because in
virology, many species are represented by only one strain/isolate sharing the
same name as the species it is assigned to. And to be honest, though I
think I’ve cleared my mind as to the virus I’ve been actually working on, I can
still be a little confused when it comes to other viruses. Like the example you
are actually giving right above!

I did understand that the finding of distinct
isolates was reason enough to create 5 distinct species within the genus Ebolavirus. But here is what I am not sure of: as long as
the ICTV hasn’t ratified the revised version of the genus Ebolavirus, what would be the most accurate way to describe the
current outbreak in Uganda? Should we say that Sudan ebolaviruses are infecting
people and are responsible for the disease? Is that how the virions should be
called based on the current, ratified taxonomy? Or do I not understand how the whole terminology of taxonomy works after all?

Thank you very much in advance for your answer and sorry for having written such a long comment to ask such a short question…

Audrey
 

My feeling with these things is that it is best to make a distinction between formal taxonomy (and usage), and, where the public is concerned, clarity. As long as there is no confusion, ebola virus is more understandable to the average Joe than ebolavirus. And if that helps people approach the science and understand the issues, that’s why we publish in these media.

My supervisors told me how people once tried changing the name of measles virus to human morbillivirus in order to make it easier to understand and place it into context with other related viruses. Truth be told this didn’t catch on and even if it was formally recognised I doubt people would have really stopped the usage of measles. 

Once a name like that is out there you it will be very hard to put the genie back in the bottle so to speak. Same with something like mumps. As Alan says below, you’ve got to weigh up the pros and cons for the technical and lay communities. 

The purpose of viral taxonomy is to allow virologists to have a file system that makes sense, reveals similarities and differences, and to help guide their thinking. It is not to allow non-scientists to easily understand what a virus is or is not. If we simplify it for the public, we will lose its utility for virologists. I don’t know what the solution is, but I’ve always felt that dumbing down science is not the answer. On the other hand, if the article says ‘Sudan virus’, no one except virologists will know that it is an Ebolavirus. What’s wrong with saying at the beginning of the article, ‘Sudan virus’, one of the Ebolaviruses…’?

Formal taxonomy has it place. But in writing for the public (on general news websites), clarity trumps formality. Otherwise, you’d just tell the public to go and read your papers in PNAS.

You are right, my wording wasn’t entirely correct. I used the term ‘Ebolavirus’ throughout the article, no italics. I should have used ‘Sudan Ebolavirus’ according to current nomenclature, or ‘Sudan virus’, according to the new nomenclature. One of my reasons for writing this post was to sort out this nomenclature issue.

I only
discovered this discussion now. As the lead author of the two papers discussed
in this thread (and as the current ICTV _Filoviridae Study Group Chair) I hope
I can clear up a few things.

The new
filovirus taxonomy as outlined in Dr. Racaniello’s blog has been fully accepted
by the ICTV a few months ago (with the exception of the
“cuevaviruses”, i.e. the proposed genus “Cuevavirus” and
species “Lloviu cuevavirus” for the recently discovered filovirus
Lloviu virus).

If you take a
step back, then you will quickly see that the new nomenclature now resembles
that for many other viruses. The five viruses that, based on molecular data,
clearly belong to five different species in the genus _Ebolavirus (the
ebolaviruses) need to be considered as different entities, and therefore need
to have different names. When deciding on names, the following considerations
were taken into account:

1.       Filovirus names should
look like names for all other viruses, i.e. follow the format “xxx virus”.
According to the nomenclature in place at the time of discussion, this was not
the case (viruses were called Zaire ebolavirus, Sudan ebolavirus etc.)

2.       Virus names should not
be identical to species names, as otherwise virus and species can easily be
confused (at the time, Zaire ebolavirus was a member of the species _Zaire
ebolavirus etc.)

3.       The right of the
discoverer of a virus to name the virus should be respected and given names
should not be changed if not absolutely necessary. As Dr. Racaniello points out
correctly, the first ebolavirus to be discovered was given the name “Ebola
virus” by Karl Johnson, not “Zaire ebolavirus”; and the first marburgvirus to
be discovered was given the name “Marburg virus” by Rudolf Siegert (not “Lake
Viktoria marburgvirus”). Confusion arose because other filoviruses were later
discovered that at first looked like Ebola virus. Hence they were first named
subtypes (Ebola virus Sudan subtype etc.) before they were recognized as
distinct viruses and especially non-molecular biologists in the field have not
yet fully accepted the fact that these five viruses are really five different
viruses

4.       Names should not be used
when they prove to be derogatory (“Ivory Coast ebolavirus” was an unfortunate
name because it’s a jargon term – not an official translation of the country
Côte d’Ivoire; and there were objections to use “Côte d’Ivoire” in a virus
name)

5.       Abbreviations of viruses
should not have the same pronunciation as it makes their use in talks pointless
(at the time, the abbreviations for “Zaire ebolavirus”, “Sudan ebolavirus”, and
“Côte d’Ivoire ebolavirus” were ZEBOV, SEBOV, and CIEBOV… )

6.       Finally, to follow the
rules of the ICTV, taxon names should be changed as little as possible.

The Study Group
therefore came up, among others, with the following solutions:

1.       Re-instate the names
“Ebola virus” and “Marburg virus” to honor the discoverers – which required
abolishing the abbreviation ZEBOV (therefore replaced with the original
abbreviation EBOV) but which allowed to keep the abbreviation MARV (which was
also the abbreviation for “Lake Victoria marburgvirus”)

2.       Keep the existing
species names _Zaire ebolavirus, _Sudan ebolavirus, _Reston ebolavirus etc.,
but change the species name _ Côte d’Ivoire ebolavirus (now Tai Forest
ebolavirus)  to address the concern about
“Côte d’Ivoire”

3.       Change the names of the
viruses assigned to the species _Sudan ebolavirus, _Reston ebolavirus, and _Tai
Forest ebolavirus to Sudan virus, Reston virus, and Tai Forest virus. This made
them different from species names, adhere to common virus naming conventions,
and kept the word stems that everybody is used to (“here we infected with
Sudan…”) – but these new names then required new abbreviations.

Now, in a
discussion outside of scientific circles, should we use “Ebola virus” for all
ebolaviruses?

Take, for
instance, the henipaviruses. If you look into the press, you find very few
articles describing a new “henipavirus disease outbreak” (or worse, a
“henipa virus disease outbreak”). Instead, reports address Hendra
virus disease outbreaks, or Nipah virus disease oubreaks – even though the
disease caused by both, severe encephalitis, may be similar. It’s even more
true if the disease is different (“Measles virus” vs. “Mumps virus” is of
course used and not “paramyxovirus”).

In the case of
filoviruses, clear differentiation of viruses may be meaningful. Take, for
instance, the current ebolavirus disease outbreak in Uganda. Ebola virus (EBOV)
has never been detected in this country, whereas Bundibugyo virus (BDBV) and
Sudan virus (SUDV) are endemic. BDBV and SUDV cause similar disease as EBOV
with one important difference: lethality of BDBV and SUDV disease outbreaks is
usually around 50% or lower, whereas EBOV disease outbreaks often reach 80% or
more. EBOV therefore is “worse” than SUDV. Pointing out, in the press or in
government reports, that the virus that causes disease in Uganda, SUDV, is
related to Ebola virus (EBOV) might send a different message than saying that
“IS Ebola virus”. On the one hand, the Ugandan government may increase awareness
with using the catch phrase “Ebola virus” and people may modify their behavior
and therefore decrease transmission. On the other hand, people may also become
panicky and change their behavior that furthers spread (leave affected villages
rather than go to a hospital upon suspicion of infection). A country will also
get different international headlines depending on the catch phrase, which can
affect trade (neighbor countries closing borders or stopping import of, say,
meat products) and also tourism. Personally, for these reasons and of course
for scientific accuracy, I would prefer headlines that state a “Sudan virus
disease outbreak” in Uganda, and a specifying line in the article such as
“Sudan virus, a relative of Ebola virus…”. This would make clear that the
situation is serious, but also that it is not as serious as it would be in the
case of an Ebola virus epidemic.

Specific
comments to individual posts:

-         
Guest:
You are right, one cannot become infected with a genus (or a species or any
other taxon). So, one cannot become infected with _Ebolavirus. But the members
of each species have a vernacular name. The members of the genus _Ebolavirus
(italicized, capitalized) are called ebolaviruses (not italicized, not
capitalized). And therefore one can become infected with AN ebolavirus. This is
why adherence to italicization and capitalization rules is important in virus
nomenclature. This is exactly the same for all other virus groups: the members
of the family_Paramyxoviridae are called paramyxoviruses; the members of the
genus _Flavivirus are called flaviviruses and so on. By the way, there are no
abbreviations for “paramyxoviruses” or “flaviviruses” - only for individual
members of these groups. That is also the reason why there is no abbreviation
for “ebolaviruses”, but there is one for one particular ebolavirus, Ebola virus
(EBOV).

-         
Connor
Bamford: of course, changing virus names just for the heck of it is silly.
Measles virus will remain measles virus for a very long time and a change to
“human morbillivirus” would only confuse everybody and be LESS precise (as I am
sure there are human morbilliviruses other than measles virus out there).
Likewise, I am not sure whether human herpesvirus 1 will ever catch on for
herpes simplex virus 1. But in the case of filoviruses, this is different. If
you go into PubMed, go search for “Zaire ebolavirus [title]” and compare that
to “Ebola virus [title] ”. You will quickly see that Ebola virus has been used
in 95% or more of all the publications. Now if you look into these publications
you will see that the majority of them actually addresses what is now again
called Ebola virus – namely the entity discovered in Zaire in 1976 by Karl
Johnson. Very few papers actually address Sudan virus or the other
ebolaviruses. Likewise, do the same exercise for marburgviruses. You will find
only a handful of articles who use the name “Lake Viktoria marburgvirus” in the
title (ironically, you will find one written by me), whereas all others use
“Marburg virus”. The change of names we brought forward therefore simply makes
correct what is used anyway; and “forces” changes on things barely used.

-         
And
Audrey Richard is absolutely right, in my opinion, because the case he
describes has almost already happened: Lloviu virus (LLOV) is a novel filovirus
not known to be pathogenic to people. As a filovirus, it is related to
ebolaviruses (although not closely enough to be grouped in the same genus
_Ebolavirus), and of course the headlines therefore read “Ebola virus found in
Spain”. Such a headline is more than misleading as it implies it is dangerous
to go into certain areas of Spain…

-         
And
one more time Audrey Richard: we used the dog breeds as a visual example for
the difference between a species and individuals. This example is not entirely
correct, as dog breeds are of course artificially selected for being
particularly different. The right example would be you vs. me as examples of
“isolates” of the members of the species _Homo sapiens (humans). The problem is
that sample size in virology is still small. But I am sure we all agree that
there are millions of viruses out there, not only the 3,000 or so currently
described, and that hundreds, thousands or even millions of individual variants
of each individual virus exist in all their individual hosts (think variants of
a particular herpesvirus in the entire human population…). Taxa are designed to
encompass all of these variants, even if they are not yet in our hands.

 
Pheww. Sorry
for being lengthy. I hope this was somewhat useful.

Thanks Jens! Your reply is almost as long as your paper We still have to meet for a beer!