TWiV 159: Flu gets the REDD light

28 November 2011

ferretHosts: Vincent RacanielloAlan Dove, and Rich Condit

Vincent, Alan, and Rich review concern over an influenza H5N1 transmission experiment, and a new host defense protein against RNA viruses.

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Weekly Science Picks

Rich – Livescribe Smartpen
Alan – Royal Society journal archive
Vincent - Chronic fatigue syndrome and the CDC by Dave Tuller

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  • http://profiles.google.com/ellenjhunt Ellen Hunt

    That method CIDRAP report is concerned about of making a microorganism more virulent (works for mortality and for transmission, depending on selection criteria) is not news. It has been publicly published to the general public twice before. Without a report of concern, the paper would have passed unnoticed, most likely.

    Alibek published it in Biohazard.
    Laurie Garrett published it. I believe it was in Collapse of Global Public Health.

    Yes. It works. It works well. Nothing to be gained by putting one’s head in the sand.

  • http://twitter.com/cggbamford Connor Bamford

    What about this paper: http://www.ncbi.nlm.nih.gov/pubmed/21825167 published in August this year. Here they identified the gene (specifically, the activity of NA) responsible for H1N1 transmissibility in ferrets. Although this is in a different – and less dangerous – strain, I don’t remember this kind of media attention revolving around this paper, which essentially deals with the same problem and could be used by hypothetical molecular biologist/bioterrorists. 

    We should now also take bets on what gene(s) it turns out to be.

  • gsgs

    twiv159.mp3 ,

    2:00 basements,humour

    4:00 listener servey, 10000 regular listeners (!! surprise), 400 surveys so
    far

    6:00 letter,CIDRAP,Fouchier et.al.

    9:00 questioning H2H of H5N1

    9:30 probably around for decades,centuries

    10:20  assumes alpha2-3–>alpha2-6

    5 mutations(no mention of 2aa)

    11:50 engineered mutations , not transmissable

    12:50 retains lethality

    13:20 Fouchier called ferret-passage “stupid experiment”

    14:40  attenuate it by passage

    16:30  should be published*3

    17:00  animal model completely inappropriate (Kawaoke 2009)

    18:00 computer-security

    21:00 pro transparency

    22:30  nature is better in making deadly viruses *3

    26:00 Congress shouldn’t decide about this regulation but rather scientific
    regulation boards

    28:00  shouldn’t be done (if you think it makes a dangerous virus),

    [which obviously the 3 discussants here don't think. As the accompanying
    sensationalism

    was inappropriate,partially wrong they conclude that there is no reason for
    the whole concern

    in the first place]

    33:00 funding should already regulate it

    37:00 no response from Palese (yet)

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    38:00 NS1   RADD1(?) (pronounced redone)

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    58:00  Uta Schwedler

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    1:00:15  pox lollipop

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    1:02:30  chicungunya

    —————————

    1:05,1:07,1:08herpesB,1:11,1:14

    1:14  Royal Society makes articles free  philosophical transactions
    <1940 (1918flu?searchable?)

    1:16

    1:17

     

     

     

     

     

     

  • gsgs

    still nothing from Palese ?

  • gsgs

    OK, some comments from
    Roth,Lowen,Palese,Perez,Racaniello, Webby, (general research)
    are here
    http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/news/dec2311ferrets-jw.html