Virology lecture #20: Vaccines

3 May 2010

Download: .wmv (314 MB) | .mp4 (82 MB)

Visit the virology W3310 home page for a complete list of course resources.

  • gsgs

    wrong lesson (#19)

  • gsgs

    I'd like to have the last part about eliminating viruses from the planet
    without having to listen to the whole lesson
    Is there a software to cut these videos ?

  • gsgs

    life expectancy curves (cause) http://magictour.free.fr/panflu/usdeath.JPG

    herd immunity % threshold
    –> no outbreak in areas with smaller population density
    not existing = better than immune ?!

    doesn't seem to work this way

    [25min through, from 63]

  • gsgs

    it omehow seems to depend, how it's downloaded.
    Sometimes I can switch forward sometimes not.
    seems that VRR is pessimistic about eradication….

    eradicate flu ?
    eradicate it (flu-A) in birds –> no more pandemics

    create a mild or asymptomatic flu and let it outcrowd other strains
    in an artificial pandemic

    one day we may create universal flu vaccine
    one day we may upload epitopes directly to the immune system
    one day we may create cheap antibodies
    one day we may create virus-eating machines (nanotech ?)
    or connect the immune-system to a computer-chip

  • http://www.virology.ws profvrr

    Yes, you can edit the videos. What are you using, pc, mac, linux?

  • http://www.virology.ws profvrr

    I don't see how you could eradicate influenza in all the animal
    reservoirs. Birds are the main one; you could not possibly find all
    the infected ones. And if you did, and eliminated the infection,
    perhaps the virus in other animals would fill the void. At least with
    today's technology, eradication of influenza is impossible. But I'm
    training tomorrow's virologists who might have better tools.

  • gsgs

    “impossible” usually means : we need more money for that …

    create a new human virus, which causes very mild disease and is more fit than current viruses
    Find it through extensive testing and reassortments in the lab or by computer-simulation
    or whatever.
    Use this new manmade virus as a living,replicating vaccine, attach epitopes to it from
    other viruses against which we want immunity.
    Whenever an epidemic wave threatens, generate a counter-(mild)epidemic with
    this virus to create protection.
    Equip it with immunity evasion = variable envelopes.
    With our knowledge we should be able to create “better” viruses than nature can.

  • gsgs

    “impossible” usually means : we need more money for that …

    create a new human virus, which causes very mild disease and is more fit than current viruses
    Find it through extensive testing and reassortments in the lab or by computer-simulation
    or whatever.
    Use this new manmade virus as a living,replicating vaccine, attach epitopes to it from
    other viruses against which we want immunity.
    Whenever an epidemic wave threatens, generate a counter-(mild)epidemic with
    this virus to create protection.
    Equip it with immunity evasion = variable envelopes.
    With our knowledge we should be able to create “better” viruses than nature can.

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    nice theme. but it takes a while to load