Hosts: Vincent Racaniello and Adolfo Garcia-Sastre
Vincent speaks with Adolfo Garcia-Sastre talk about the origin, pathogenesis, and prevention of the 2009 pandemic influenza H1N1 virus.
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Links for this episode:
- Influenza virus receptor specificity and disease
- PB1-F2 expression by 2009 H1N1 strain does not increase virulence
- Protection against 2009 H1N1 infection by immunization with older strains
- Passage in eggs changes influenza receptor specificity
- Association between D222G mutation and virulence
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{thanks for that.
GS is a bit hard to understand. Maybe Spanish with the choppy syllables spreads flu
better than English (i.e. Spanish flu and Mexican flu ) – has it been examined ? }
will it replace oldflu
protection for 1/2 year (or 1.5 years) {but waves typically take 10 weeks ?!}
cellular immunity
antigenic sin 13:30 , plays no major role
different subtype with antisera ? 15:55 {but similar to swine H1 which comes from 1918}
>65y protected ,
H1 in pigs is antigenically more stable than in humans
20:50 Gibbs
{Gibbs discusses here: http://fluboard.rhizalabs.com/forum/viewtopic.p…
{where discusses GS ?}}
22:30 reassorted in humans ?
{smoking pig analysis: http://www.setbb.com/fluwiki2/viewtopic.php?t=1…
this pig probably doesn't descend from the original mexflu}
not more virulent in children than oldflu
{but papers give a much higher CFR}
R. mentions Ukraine wrt. D225G(H3) !
225G doesn't spread , {spread of mixed viruses, 225D and 225G ?}
35:08 PB1-F2 {test the effect in mallards {waterborne transmission}, please}
surprised by H1 being the pandemic , not surprised by swine initiating the pandemic
1976 vaccine study underway
we need better vax for older people
3 shots per life, universal vaccine
cross protection , some regions in HA conserved in all HA
{but how will the antibodies detect them when the virus hides them,
doesn't work for seasonal flu, same serotype}
{thanks for that.
GS is a bit hard to understand. Maybe Spanish with the choppy syllables spreads flu
better than English (i.e. Spanish flu and Mexican flu ) – has it been examined ? }
will it replace oldflu
protection for 1/2 year (or 1.5 years) {but waves typically take 10 weeks ?!}
cellular immunity
antigenic sin 13:30 , plays no major role
different subtype with antisera ? 15:55 {but similar to swine H1 which comes from 1918}
>65y protected ,
H1 in pigs is antigenically more stable than in humans
20:50 Gibbs
{Gibbs discusses here: http://fluboard.rhizalabs.com/forum/viewtopic.p…
{where discusses GS ?}}
22:30 reassorted in humans ?
{smoking pig analysis: http://www.setbb.com/fluwiki2/viewtopic.php?t=1…
this pig probably doesn't descend from the original mexflu}
not more virulent in children than oldflu
{but papers give a much higher CFR}
R. mentions Ukraine wrt. D225G(H3) !
225G doesn't spread , {spread of mixed viruses, 225D and 225G ?}
35:08 PB1-F2 {test the effect in mallards {waterborne transmission}, please}
surprised by H1 being the pandemic , not surprised by swine initiating the pandemic
1976 vaccine study underway
we need better vax for older people
3 shots per life, universal vaccine
cross protection , some regions in HA conserved in all HA
{but how will the antibodies detect them when the virus hides them,
doesn't work for seasonal flu, same serotype}
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