About viruses and viral disease
1 March 2010
Download: .wmv (354 MB) | .mp4 (104 MB)
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I could watch this one with AOL. Being primarily interested in flu, I wondered:
can 2 non-infective particles with missing segments together be infective in the same cell ?if only 0ne in 400 viruses are infective then an awful lot of cells are partially infectedand disturbed invain before the infection process somehow can't proceed. Host and virusdon't want this…where are the addresses of viral parts where to move or the packaging signals ? I've read it's encoded in nucleotides, not amino-acidsbut the “assembler” only sees the nucleocapsid-complexes not the enclosed nucleotidesno more coughing in NY in March in accordance with NY-ILI-charts
Reply to GSGS,
1. Two noninfectious influenza virus particles can initiate infection if the defective or missing gene segment is not the same, i.e. for example if one particles is missing a polymerase whilst the other lacks the M gene segment they will complement each other. This is called multiplicity-dependent reactivation. 2. We study biological activities of influenza noninfectious particles. By noninfectious I mean a particle that can enter the cell but fail to replicate and produce new particles [that can infect new host cells]. These particles particles are important in for examples, inducing interferon, interfering with the replication of [fellow] infectious particles during coinfection, or killing the host cell thereby reducing the number of competent cells for replication of infectious particles. This latter function is unfortunately accompanied by enhanced pathogenesis.
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