TWiV 71: Please Mr. Postman

28 February 2010

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Vincent, Dickson, Alan, and Rich answer listener questions about maternal infection and fetal injury, viral gene therapy, eyeglasses and influenza, filtering prions from blood, eradication of rinderpest, Tamiflu resistance of H1N1 influenza, bacteriophages and the human microbiome, H1N1 vaccine recalls, human tumor viruses, RNA interference, and junk DNA.

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  • BrianHanley

    The article on rinderpest really should mention Dr. Yilma, who developed the vaccinia based vaccine that is stable enough in the field to have high efficacy. He left Ethiopia to develop that vaccine and did it.

  • dmcilroy

    On the question from a biology student about antiviral gene therapy. T-cell receptor gene transfer has been proposed as a therapy for HIV infection. There was a paper in Nature Medicine in 2008 on this subject ( http://www.ncbi.nlm.nih.gov/pubmed/18997777). The idea is that by enhancing the TCR binding, it would be a way to help T-cells recognize viral escape variants. Apparently a clinical trial has been approved to test this approach (at U Penn, I believe).

    Otherwise, for rinderpest, I thought the vaccine used in the eradication campaign was an attenuated rinderpest virus, not a vaccinia recombinant. As that right?

    DMc

  • http://www.virology.ws profvrr

    You are correct, the rinderpest vaccine is an attenuated strain, not a
    vaccinia recombinant. We'll fix this on an upcoming TWiV.

  • http://www.virology.ws profvrr

    You are correct, the rinderpest vaccine is an attenuated strain, not a
    vaccinia recombinant. We'll fix this on an upcoming TWiV.