Comments on: TWiP 3: Trichinella spiralis http://www.virology.ws/2009/12/28/twip-3-trichinella-spiralis/ About viruses and viral disease Sat, 11 Feb 2012 17:38:00 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: Chris http://www.virology.ws/2009/12/28/twip-3-trichinella-spiralis/comment-page-1/#comment-21529 Chris Mon, 04 Jan 2010 00:47:29 +0000 http://www.virology.ws/?p=2613#comment-21529 I very much enjoy Prof. Despommeir's way of telling a story. This is what makes both TWiV and TWiP good listening for me (no medical or biology background, just an interest). I very much enjoy Prof. Despommeir's way of telling a story. This is what makes both TWiV and TWiP good listening for me (no medical or biology background, just an interest).

]]> By: Chris http://www.virology.ws/2009/12/28/twip-3-trichinella-spiralis/comment-page-1/#comment-19536 Chris Sun, 03 Jan 2010 16:47:29 +0000 http://www.virology.ws/?p=2613#comment-19536 I very much enjoy Prof. Despommeir's way of telling a story. This is what makes both TWiV and TWiP good listening for me (no medical or biology background, just an interest). I very much enjoy Prof. Despommeir's way of telling a story. This is what makes both TWiV and TWiP good listening for me (no medical or biology background, just an interest).

]]> By: josh89 http://www.virology.ws/2009/12/28/twip-3-trichinella-spiralis/comment-page-1/#comment-19498 josh89 Wed, 30 Dec 2009 13:20:12 +0000 http://www.virology.ws/?p=2613#comment-19498 Very informative and easy to follow podcast. Just one small error I noticed regarding your brief definition of Paget's disease. Dick said it was a 'degenerative disease of the spinal cord' which is not correct. It is a bone disease caused by excessive breakdown and pathological laying down of new bone. This leads to weakened but enlarged and often malformed bone. The abnormal bone growth can interfere with nerves due to impingement but it is not primarily a disease of bone. <br><br>At medical school we were told it is caused by genetic factors but upon undertaking some research I found it may also be caused by virus infection! Including measles virus and respiratory syncitial virus. Here are a few references for interest's sake:<br><br><a href="http://en.wikipedia.org/wiki/Paget%2527s_disease_of_bone#cite_note-pmid11771661-2" rel="nofollow">http://en.wikipedia.org/wiki/Paget%27s_disease_...</a><br><br>Friedrichs WE, Reddy SV, Bruder JM, et al. (January 2002). "Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease". J. Bone Miner. Res. 17 (1): 145–51. doi:10.1359/jbmr.2002.17.1.145. PMID 11771661. <br><br>Baslé MF, Fournier JG, Rozenblatt S, Rebel A, Bouteille M (May 1986). "Measles virus RNA detected in Paget disease bone tissue by in situ hybridization". J. Gen. Virol. 67 ( Pt 5): 907–13. PMID 3701300. <a href="http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=3701300" rel="nofollow">http://vir.sgmjournals.org/cgi/pmidlookup?view=...</a>. <br><br>Matthews BG, Afzal MA, Minor PD, et al. (April 2008). "Failure to detect measles virus ribonucleic acid in bone cells from patients with Paget's disease". J. Clin. Endocrinol. Metab. 93 (4): 1398–401. doi:10.1210/jc.2007-1978. PMID 18230662. <a href="http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=18230662" rel="nofollow">http://jcem.endojournals.org/cgi/pmidlookup?vie...</a>. <br><br>Mills BG, Singer FR, Weiner LP, Holst PA (February 1981). "Immunohistological demonstration of respiratory syncytial virus antigens in Paget disease of bone". Proc. Natl. Acad. Sci. U.S.A. 78 (2): 1209–13. doi:10.1073/pnas.78.2.1209. PMID 6940136. Very informative and easy to follow podcast. Just one small error I noticed regarding your brief definition of Paget's disease. Dick said it was a 'degenerative disease of the spinal cord' which is not correct. It is a bone disease caused by excessive breakdown and pathological laying down of new bone. This leads to weakened but enlarged and often malformed bone. The abnormal bone growth can interfere with nerves due to impingement but it is not primarily a disease of bone.

At medical school we were told it is caused by genetic factors but upon undertaking some research I found it may also be caused by virus infection! Including measles virus and respiratory syncitial virus. Here are a few references for interest's sake:

http://en.wikipedia.org/wiki/Paget%27s_disease_…

Friedrichs WE, Reddy SV, Bruder JM, et al. (January 2002). “Sequence analysis of measles virus nucleocapsid transcripts in patients with Paget's disease”. J. Bone Miner. Res. 17 (1): 145–51. doi:10.1359/jbmr.2002.17.1.145. PMID 11771661.

Baslé MF, Fournier JG, Rozenblatt S, Rebel A, Bouteille M (May 1986). “Measles virus RNA detected in Paget disease bone tissue by in situ hybridization”. J. Gen. Virol. 67 ( Pt 5): 907–13. PMID 3701300. http://vir.sgmjournals.org/cgi/pmidlookup?view=….

Matthews BG, Afzal MA, Minor PD, et al. (April 2008). “Failure to detect measles virus ribonucleic acid in bone cells from patients with Paget's disease”. J. Clin. Endocrinol. Metab. 93 (4): 1398–401. doi:10.1210/jc.2007-1978. PMID 18230662. http://jcem.endojournals.org/cgi/pmidlookup?vie….

Mills BG, Singer FR, Weiner LP, Holst PA (February 1981). “Immunohistological demonstration of respiratory syncytial virus antigens in Paget disease of bone”. Proc. Natl. Acad. Sci. U.S.A. 78 (2): 1209–13. doi:10.1073/pnas.78.2.1209. PMID 6940136.

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