Comments on: Novartis influenza A H1N1 vaccine clinical data

By: kikan

kikan — Thu, 26 Nov 2009 10:39:26 +0000

hi, the side effect which happened recently is not those small swelling at the injection side, but is the swelling of tongue, and the swelling of the whole leg. These seems to be quite serious to me. May I know is this kind of swelling consider as dangerous?

What is the different in the H1N1 vaccine produce by Novartis and GSK or other company? How do we know which Vaccine is safer?

By: Novartis influenza A H1N1 vaccine clinical data | H3N2FLU.US

Novartis influenza A H1N1 vaccine clinical data | H3N2FLU.US — Thu, 26 Nov 2009 10:30:29 +0000

[...] It is made in the same way as the 2009 H1N1 vaccine; the … Originally posted here: Novartis influenza A H1N1 vaccine clinical data Posted in H3N2 Influenza Information. Tags: same, seasonal, the, the-2009, the-same, [...]

By: profvrr

profvrr — Wed, 25 Nov 2009 16:37:12 +0000

The 'normal' influenza vaccine, or the seasonal vaccine, consists of
three different viruses: seasonal H1N1 and H3N2, and an influenza B
virus strain. It is made in the same way as the 2009 H1N1 vaccine; the
only difference is that vaccine contains only one virus, the pandemic
H1N1 strain. Side effects such as swelling at the injection site,
fever, and rashes were reported in the clinical trial and are not
unexpected when the vaccine is used in the general population.
Clinical trials cannot prove that a vaccine is 100% safe; but they can
provide information on commonly occurring side effects.

By: kikan

kikan — Wed, 25 Nov 2009 09:44:55 +0000

hi,
there are news about H1N1 vaccine getting side effects like swelling, rashes and fever happening recently. So how do these clinical trial prove to us that they are really safe?
What is the different between (Influza A) H1N1 vaccine and the normal influza vaccine?
Please advise. Thank you.

By: profvrr

profvrr — Thu, 19 Nov 2009 00:33:05 +0000

According to the Novartis results, one shot of a half-dose provides
protective immunity. So the kids should be protected after one dose if
they received the Novartis vaccine. The vaccines of the other
manufacturers haven't been tested at half dose, so we don't know if
they would be fully protective. But I think some protection would be
conferred, at least to make the disease milder if acquired.

By: Tweets that mention Novartis influenza A H1N1 vaccine clinical data -- Topsy.com

Tweets that mention Novartis influenza A H1N1 vaccine clinical data -- Topsy.com — Wed, 18 Nov 2009 22:39:32 +0000

[...] This post was mentioned on Twitter by Vincent Racaniello, Daniel Ferreira. Daniel Ferreira said: Novartis influenza A #H1N1 vaccine clinical data http://bit.ly/2CeEnX at virology blog #swineflu [...]

By: trinetsouderos

trinetsouderos — Wed, 18 Nov 2009 20:20:37 +0000

I think a lot of parents who had a hard time getting their kids the first dose may find it difficult to get their kids the booster four weeks later. For many kids, it will be many weeks after that. How protected are the kids until they get that second immunization?

By: profvrr

profvrr — Wed, 18 Nov 2009 20:14:35 +0000

Hi Trine,

Immune responses peak in ~3 weeks, therefore 4 weeks is used just to be safe. See figure in http://www.virology.ws/2009/07/22/adaptive-immu.... You want to wait for the primary response to be over before boosting.

By: trinetsouderos

trinetsouderos — Wed, 18 Nov 2009 20:11:32 +0000

Hi Vincent,
Quick question: Why four weeks apart? Is there some special reason for this, and what if it is five weeks apart, or more, or less? How do they determine the spacing? Thanks, T