Comments on: Is yearly influenza vaccination of children a bad idea? http://www.virology.ws/2009/11/06/is-yearly-influenza-vaccination-of-children-a-bad-idea/ About viruses and viral disease Sat, 11 Feb 2012 17:38:00 +0000 hourly 1 http://wordpress.org/?v=3.3.1 By: marketa http://www.virology.ws/2009/11/06/is-yearly-influenza-vaccination-of-children-a-bad-idea/comment-page-1/#comment-21881 marketa Sat, 21 Nov 2009 15:31:44 +0000 http://www.virology.ws/?p=2273#comment-21881 thanx for reply, i try to make my concerns a bit clearer.. lets assume they get their vaccine, that protect them from this "swine" flu, but the flu mutates, their antigenic sin would not recognize the new strain and thats why it coud not protect them against it..the same as if you get seasonal flu shot, it wud not help u much against the swine flu..am I right? and if the flu mutates to even more similar flu as the one in 1918, which caused pheumonie mostly by young healthy adults, on wiki they said, their healthy imune system was a liability, as the cytokine storm hits them..so small childrena and elderly was not as afected..so if I boost them with adjuvant, their imunte system becomes stronger, right? Its all too much at the moment, as I read reports from ukraine.. the swine flu suppose to be mild, most of the time, the same as seasonal flu, more fever and coughing, but otherwise the same. though they vaccinate as mad.. and we dont know, there is no time for all the necessery testing..there is new vacine padenza from france, which should not be as bad, as they say, no adjuvants, tested etc.. <br>whats other people opinion? thanx for reply, i try to make my concerns a bit clearer.. lets assume they get their vaccine, that protect them from this “swine” flu, but the flu mutates, their antigenic sin would not recognize the new strain and thats why it coud not protect them against it..the same as if you get seasonal flu shot, it wud not help u much against the swine flu..am I right? and if the flu mutates to even more similar flu as the one in 1918, which caused pheumonie mostly by young healthy adults, on wiki they said, their healthy imune system was a liability, as the cytokine storm hits them..so small childrena and elderly was not as afected..so if I boost them with adjuvant, their imunte system becomes stronger, right? Its all too much at the moment, as I read reports from ukraine.. the swine flu suppose to be mild, most of the time, the same as seasonal flu, more fever and coughing, but otherwise the same. though they vaccinate as mad.. and we dont know, there is no time for all the necessery testing..there is new vacine padenza from france, which should not be as bad, as they say, no adjuvants, tested etc..
whats other people opinion?

]]> By: marketa http://www.virology.ws/2009/11/06/is-yearly-influenza-vaccination-of-children-a-bad-idea/comment-page-1/#comment-18730 marketa Sat, 21 Nov 2009 07:31:44 +0000 http://www.virology.ws/?p=2273#comment-18730 thanx for reply, i try to make my concerns a bit clearer.. lets assume they get their vaccine, that protect them from this "swine" flu, but the flu mutates, their antigenic sin would not recognize the new strain and thats why it coud not protect them against it..the same as if you get seasonal flu shot, it wud not help u much against the swine flu..am I right? and if the flu mutates to even more similar flu as the one in 1918, which caused pheumonie mostly by young healthy adults, on wiki they said, their healthy imune system was a liability, as the cytokine storm hits them..so small childrena and elderly was not as afected..so if I boost them with adjuvant, their imunte system becomes stronger, right? Its all too much at the moment, as I read reports from ukraine.. the swine flu suppose to be mild, most of the time, the same as seasonal flu, more fever and coughing, but otherwise the same. though they vaccinate as mad.. and we dont know, there is no time for all the necessery testing..there is new vacine padenza from france, which should not be as bad, as they say, no adjuvants, tested etc.. <br>whats other people opinion? thanx for reply, i try to make my concerns a bit clearer.. lets assume they get their vaccine, that protect them from this “swine” flu, but the flu mutates, their antigenic sin would not recognize the new strain and thats why it coud not protect them against it..the same as if you get seasonal flu shot, it wud not help u much against the swine flu..am I right? and if the flu mutates to even more similar flu as the one in 1918, which caused pheumonie mostly by young healthy adults, on wiki they said, their healthy imune system was a liability, as the cytokine storm hits them..so small childrena and elderly was not as afected..so if I boost them with adjuvant, their imunte system becomes stronger, right? Its all too much at the moment, as I read reports from ukraine.. the swine flu suppose to be mild, most of the time, the same as seasonal flu, more fever and coughing, but otherwise the same. though they vaccinate as mad.. and we dont know, there is no time for all the necessery testing..there is new vacine padenza from france, which should not be as bad, as they say, no adjuvants, tested etc..
whats other people opinion?

]]> By: profvrr http://www.virology.ws/2009/11/06/is-yearly-influenza-vaccination-of-children-a-bad-idea/comment-page-1/#comment-18689 profvrr Thu, 19 Nov 2009 12:28:32 +0000 http://www.virology.ws/?p=2273#comment-18689 On the contrary, immunization boosts the immune response. On the contrary, immunization boosts the immune response.

]]> By: marketa http://www.virology.ws/2009/11/06/is-yearly-influenza-vaccination-of-children-a-bad-idea/comment-page-1/#comment-18658 marketa Wed, 18 Nov 2009 08:54:32 +0000 http://www.virology.ws/?p=2273#comment-18658 hi, im researching lot of websites on this theme, but it is not clear to me, as im no scientist, but mother of 2 young chilldren, due to be vaccinated.. if there is a new strain of flu, will not be their imune system weekened after the vaccination?<br>can you please let me know? hi, im researching lot of websites on this theme, but it is not clear to me, as im no scientist, but mother of 2 young chilldren, due to be vaccinated.. if there is a new strain of flu, will not be their imune system weekened after the vaccination?
can you please let me know?

]]> By: epringle http://www.virology.ws/2009/11/06/is-yearly-influenza-vaccination-of-children-a-bad-idea/comment-page-1/#comment-18352 epringle Fri, 06 Nov 2009 21:37:12 +0000 http://www.virology.ws/?p=2273#comment-18352 We should still expect a CD8+ T cell response to inactivated vaccine due to MHC cross-presentation by dendritic cells at the site of inoculation.<br><br>The evidence in Bodewes et al., was based on a subunit vaccine, not an inactivated virus. The J Immunol aritcle [He et al., 2006] they cite in support shows that live attenuated virus produce a strong CD8 response however they also show a lesser, but still greatly increased CD8 response with inactivated virus. <br><br>What concerns me here is original antigenic sin. If we vaccinate with attenuated virus we may prevent a protective immune response to a more virulent strain in the future. We do not observe substantial original antigenic sin in inactivated virus vaccines. We should still expect a CD8+ T cell response to inactivated vaccine due to MHC cross-presentation by dendritic cells at the site of inoculation.

The evidence in Bodewes et al., was based on a subunit vaccine, not an inactivated virus. The J Immunol aritcle [He et al., 2006] they cite in support shows that live attenuated virus produce a strong CD8 response however they also show a lesser, but still greatly increased CD8 response with inactivated virus.

What concerns me here is original antigenic sin. If we vaccinate with attenuated virus we may prevent a protective immune response to a more virulent strain in the future. We do not observe substantial original antigenic sin in inactivated virus vaccines.

]]> By: michael http://www.virology.ws/2009/11/06/is-yearly-influenza-vaccination-of-children-a-bad-idea/comment-page-1/#comment-18349 michael Fri, 06 Nov 2009 18:43:32 +0000 http://www.virology.ws/?p=2273#comment-18349 Even if this were so, the pandemic year is exactly the year you do want a child vaccinated. <br><br>Suppressing all forest fires isn't considered good policy. But there are forest fires worth putting out. You've talked about the case for season flu vaccination being reasonable but arguable. For which groups and ages is it strongest? Even if this were so, the pandemic year is exactly the year you do want a child vaccinated.

Suppressing all forest fires isn't considered good policy. But there are forest fires worth putting out. You've talked about the case for season flu vaccination being reasonable but arguable. For which groups and ages is it strongest?

]]> By: Tweets that mention Is yearly influenza vaccination of children a bad idea? -- Topsy.com http://www.virology.ws/2009/11/06/is-yearly-influenza-vaccination-of-children-a-bad-idea/comment-page-1/#comment-18346 Tweets that mention Is yearly influenza vaccination of children a bad idea? -- Topsy.com Fri, 06 Nov 2009 18:42:26 +0000 http://www.virology.ws/?p=2273#comment-18346 [...] This post was mentioned on Twitter by Sally Church and Vincent Racaniello, Chris Upton. Chris Upton said: RT @profvrr: Is yearly influenza vaccination of children a bad idea? http://bit.ly/1CePrX at virology blog #h1n1 #swineflu [...] [...] This post was mentioned on Twitter by Sally Church and Vincent Racaniello, Chris Upton. Chris Upton said: RT @profvrr: Is yearly influenza vaccination of children a bad idea? http://bit.ly/1CePrX at virology blog #h1n1 #swineflu [...]

]]>