Comments on: No tetravalent influenza vaccine http://www.virology.ws/2009/08/26/no-tetravalent-influenza-vaccine/ About viruses and viral disease Sun, 21 Mar 2010 16:57:56 -0700 http://wordpress.org/?v=2.8.6 hourly 1 By: No tetravalent influenza vaccine virology http://www.virology.ws/2009/08/26/no-tetravalent-influenza-vaccine/comment-page-1/#comment-17458 No tetravalent influenza vaccine virology Sat, 12 Sep 2009 05:46:12 +0000 http://www.virology.ws/?p=1985#comment-17458 [...] Original post:  No tetravalent influenza vaccine [...] [...] Original post:  No tetravalent influenza vaccine [...]

]]> By: profvrr http://www.virology.ws/2009/08/26/no-tetravalent-influenza-vaccine/comment-page-1/#comment-17393 profvrr Wed, 09 Sep 2009 00:15:02 +0000 http://www.virology.ws/?p=1985#comment-17393 The problem is that the trivalent is now available here in the north,<br>and CDC feels they can't conclude that the old H3N2 and H1N1 will be<br>gone. Hence, the vaccine is being distributed. Both vaccines will<br>therefore be used. Perhaps next year we'll need a monovalent against<br>2009 H1N1, or maybe a drifted variant. The problem is that the trivalent is now available here in the north,
and CDC feels they can't conclude that the old H3N2 and H1N1 will be
gone. Hence, the vaccine is being distributed. Both vaccines will
therefore be used. Perhaps next year we'll need a monovalent against
2009 H1N1, or maybe a drifted variant.

]]> By: Ed Rybicki http://www.virology.ws/2009/08/26/no-tetravalent-influenza-vaccine/comment-page-1/#comment-17326 Ed Rybicki Fri, 04 Sep 2009 07:56:11 +0000 http://www.virology.ws/?p=1985#comment-17326 The little matter of clinical trials being necessary before ANY change in compostion of a vaccine raises its ugly head, again...which is why we will have 3-in-1 (H3N2, old H1N1 and B) and single pandemic H1N1 vaccines this year.<br><br>However, there seems to be considerable and accumulating evidence that pandemic AH1N1 2009 in the southern hemisphere is almost completely replacing the standard seasonal variants: see <a href="http://www.cdc.gov/h1n1flu/updates/international/" rel="nofollow">http://www.cdc.gov/h1n1flu/updates/international/</a> . This means that maybe you'll only need the one vaccine, come flu time in the north? The little matter of clinical trials being necessary before ANY change in compostion of a vaccine raises its ugly head, again…which is why we will have 3-in-1 (H3N2, old H1N1 and B) and single pandemic H1N1 vaccines this year.

However, there seems to be considerable and accumulating evidence that pandemic AH1N1 2009 in the southern hemisphere is almost completely replacing the standard seasonal variants: see http://www.cdc.gov/h1n1flu/updates/international/ . This means that maybe you'll only need the one vaccine, come flu time in the north?

]]> By: profvrr http://www.virology.ws/2009/08/26/no-tetravalent-influenza-vaccine/comment-page-1/#comment-17246 profvrr Tue, 01 Sep 2009 00:20:02 +0000 http://www.virology.ws/?p=1985#comment-17246 If there is an upper limit, I am not aware of it. There are some<br>vaccines which are 20-valent and above, at least for bacterial<br>infections. At some point, depending on the antigen concentration, you<br>reach a point where there is so little antigen for each pathogen that<br>the immune response is weak. If there is an upper limit, I am not aware of it. There are some
vaccines which are 20-valent and above, at least for bacterial
infections. At some point, depending on the antigen concentration, you
reach a point where there is so little antigen for each pathogen that
the immune response is weak.

]]> By: MJ http://www.virology.ws/2009/08/26/no-tetravalent-influenza-vaccine/comment-page-1/#comment-17213 MJ Fri, 28 Aug 2009 17:07:59 +0000 http://www.virology.ws/?p=1985#comment-17213 Another reason is that the vaccine for the 2009 pandemic H1N1 strain may require two doses for an adequate immune response, while people who have previously received seasonal trivalent influenza vaccine may only need one dose of seasonal vaccine. Another reason is that the vaccine for the 2009 pandemic H1N1 strain may require two doses for an adequate immune response, while people who have previously received seasonal trivalent influenza vaccine may only need one dose of seasonal vaccine.

]]> By: albatross http://www.virology.ws/2009/08/26/no-tetravalent-influenza-vaccine/comment-page-1/#comment-17212 albatross Fri, 28 Aug 2009 16:56:09 +0000 http://www.virology.ws/?p=1985#comment-17212 Is there some upper limit to how many different strains you can put in the vaccine before you start losing effectiveness? That is, why not put ten strains in, instead of three? <br><br>I assume whatever limit exists is not too low, at least not based on your immune response, since it's absolutely commonplace to get a bunch of vaccinations on the same day. Is there some upper limit to how many different strains you can put in the vaccine before you start losing effectiveness? That is, why not put ten strains in, instead of three?

I assume whatever limit exists is not too low, at least not based on your immune response, since it's absolutely commonplace to get a bunch of vaccinations on the same day.

]]> By: Twitter Trackbacks for No tetravalent influenza vaccine [virology.ws] on Topsy.com http://www.virology.ws/2009/08/26/no-tetravalent-influenza-vaccine/comment-page-1/#comment-17204 Twitter Trackbacks for No tetravalent influenza vaccine [virology.ws] on Topsy.com Fri, 28 Aug 2009 01:43:19 +0000 http://www.virology.ws/?p=1985#comment-17204 [...] link is being shared on Twitter right now. @microbytes, an influential author, said No tetravalent [...] [...] link is being shared on Twitter right now. @microbytes, an influential author, said No tetravalent [...]

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