Comments on: Adaptive immune defenses http://www.virology.ws/2009/07/03/adaptive-immune-defenses/ About viruses and viral disease Fri, 12 Mar 2010 13:40:43 -0800 http://wordpress.org/?v=2.8.6 hourly 1 By: The complement system http://www.virology.ws/2009/07/03/adaptive-immune-defenses/comment-page-1/#comment-17652 The complement system Mon, 28 Sep 2009 21:18:19 +0000 http://www.virology.ws/?p=1745#comment-17652 [...] and cell surface proteins that is a major primary defense and a clearance component of innate and adaptive immune responses. At least 30 different complement proteins act sequentially to produce a wide [...] [...] and cell surface proteins that is a major primary defense and a clearance component of innate and adaptive immune responses. At least 30 different complement proteins act sequentially to produce a wide [...]

]]> By: Adaptive immune defenses: Antibodies http://www.virology.ws/2009/07/03/adaptive-immune-defenses/comment-page-1/#comment-11201 Adaptive immune defenses: Antibodies Wed, 22 Jul 2009 20:16:13 +0000 http://www.virology.ws/?p=1745#comment-11201 [...] important to understand how vaccines work. To do this we must have a good understanding of adaptive immune defenses. Today we’ll begin a discussion of the humoral arm of the adaptive immune response – [...] [...] important to understand how vaccines work. To do this we must have a good understanding of adaptive immune defenses. Today we’ll begin a discussion of the humoral arm of the adaptive immune response – [...]

]]> By: profvrr http://www.virology.ws/2009/07/03/adaptive-immune-defenses/comment-page-1/#comment-10426 profvrr Mon, 20 Jul 2009 17:48:21 +0000 http://www.virology.ws/?p=1745#comment-10426 What is 'remembered' is conserved protein sequences that bind<br>antibodies (in the case of B cell memory, for example). Every particle<br>is not antigenically different - the genome is different but that does<br>not always translate into different protein. When differences emerge<br>in antigenic sites, that's when antigenic drift occurs, and antibodies<br>no longer neutralize the virus. More on this to come. What is 'remembered' is conserved protein sequences that bind
antibodies (in the case of B cell memory, for example). Every particle
is not antigenically different – the genome is different but that does
not always translate into different protein. When differences emerge
in antigenic sites, that's when antigenic drift occurs, and antibodies
no longer neutralize the virus. More on this to come.

]]> By: mdubuque http://www.virology.ws/2009/07/03/adaptive-immune-defenses/comment-page-1/#comment-5973 mdubuque Mon, 06 Jul 2009 23:48:13 +0000 http://www.virology.ws/?p=1745#comment-5973 What exactly is "remembered" here? Since every viral particle is different, it would seem that the adaptive system needs to remember "similarities" and not just individual signatures.<br><br>In other words, they seem to have somehow classified viruses by serial homology, in my view.<br><br>Are there disadvantages to having too broad of spectrum of "memory" in different aspects of the adaptive system? How is that memory "tuned" and "modulated"?<br><br>I remain intriuged by the notion that all this coding and "memory" in viral systems can be informed by the debate on mathematical linguistics.<br><br>Matt Dubuque What exactly is “remembered” here? Since every viral particle is different, it would seem that the adaptive system needs to remember “similarities” and not just individual signatures.

In other words, they seem to have somehow classified viruses by serial homology, in my view.

Are there disadvantages to having too broad of spectrum of “memory” in different aspects of the adaptive system? How is that memory “tuned” and “modulated”?

I remain intriuged by the notion that all this coding and “memory” in viral systems can be informed by the debate on mathematical linguistics.

Matt Dubuque

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