Comments on: Swine influenza A/Mexico/2009 (H1N1) update

By: profvrr

profvrr — Fri, 08 May 2009 05:34:28 +0000

New cases in Mexico appear to be rapidly declining
(http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5817...). There is
an excellent chance that it will all be done by June; it's very rare
to have flu outbreaks in that month.

By: teeess

teeess — Fri, 08 May 2009 05:23:37 +0000

I'm supposed to take my students to a National Convention in Dallas in June (which was post phoned from May 6-9) . I'm afraid that Texas is too close to the border, and I don't want to be in a conference with over 5,000+ students, one of which could have just come over from Mexico. What are the chances this is all going to be over by June 17?

By: profvrr

profvrr — Thu, 07 May 2009 22:34:28 +0000

By: teeess

teeess — Thu, 07 May 2009 22:23:37 +0000

By: Nucleotide sequences of A/Mexico/2009 (H1N1) available

Nucleotide sequences of A/Mexico/2009 (H1N1) available — Tue, 05 May 2009 03:11:40 +0000

[...] have not been available. Today we received a comment from Dr. Ruben Donis, who we quoted in a previous post. Dr. Donis wrote: Thank you for the nice vignette about the ScienceInsider interview. I would like [...]

By: profvrr

profvrr — Tue, 05 May 2009 00:59:20 +0000

Thank you Ruben for clarifying this. I just discovered the Mexican
sequences today. I missed the WHO announcement about GISAID as did
most readers of virology blog.

By: Ruben Donis

Ruben Donis — Tue, 05 May 2009 00:42:41 +0000

Thank you for the nice vignette about the ScienceInsider interview. I would like to point out that full genome sequences of Mexican viruses have been available in the public domain at the GISAID database http://www.gisaid.org since April 24, 2009. Sequences were posted in the public domain as soon as they were completed and curated. The availability of sequences at GISAID was also posted at the WHO website
http://www.who.int/csr/disease/swineflu/swinefl...

By: bibi

bibi — Sat, 02 May 2009 09:00:31 +0000

Thank you – your blog is great – I can find this information no where and spent hours on pubmed
I dont understand the terminology : how could two H1N1 strain be different ?
Could you explain how vaccination works : when H1N1 strains are used to produce a vaccination why wouldn't they work on “other H1N1 ” strains ? ( Hapten has changed – but not enough to call it HxNx)?
many thanks again:
from europe
bibi

By: Is it time to panic yet? - Page 2 - Volconvo Debate Forums

Is it time to panic yet? - Page 2 - Volconvo Debate Forums — Sat, 02 May 2009 02:54:22 +0000

[...] returns to the north in a more virulent form in the fall? Can a vaccine be prepared in time? Swine influenza A/Mexico/2009 (H1N1) update The Forum Rules Radical Atheist Heathen Queer Ubuntu [...]

By: profvrr

profvrr — Sat, 02 May 2009 00:42:17 +0000

You are right, it doesn't make sense. There is no reference to the
statement about Mexican isolates. They clearly are not releasing these
sequences.

By: profvrr

profvrr — Fri, 01 May 2009 23:35:15 +0000

Even though both viruses are H1N1, the Mexico isolate is very
different from the previous H1N1 and therefore there is probably no
cross-protection. So says the CDC, although no one has seen the data
that would answer the question either way. I will ask Peter Palese
this question next week on TWiV.

By: bibi

bibi — Fri, 01 May 2009 20:59:15 +0000

Hello,
could anybody answer this:
how comes that the current year's vaccin is not effectiv on the new “mexico ” H1N1 ?
The H1N1 strain is used in vaccins since 2002 ( probalbly much longer before) ?
thanks
bibi

By: Matt Dubuque

Matt Dubuque — Fri, 01 May 2009 12:34:04 +0000

At the end of the interview, Dr. Donis states that the USA has received 300 samples of this virus from Mexico.

It seems to be a conscious and intentional decison not to publish those sequences.

Why would the CDC fail to publish the sequences of any of the 300 samples Dr. Donis says they have received from Mexico?

Matt Dubuque

By: diana

diana — Fri, 01 May 2009 12:16:58 +0000

Dr. Racaniello,

This confuses me:

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0...

See note 1.

"genetically similar to viruses subsequently isolated from patients in Mexico "

Hunh?

When you click on Note one, you get

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5816...

Which doesn't contain a reference to RNA sequences of Mexican cases. Unless I am misreading - which is possible.