TWiV #18: Can a virus make you fat?

31 January 2009

twiv_aa_2001On This Week in Virology #18, Vincent, Dick, and Alan discuss adenovirus type 36 and obesity, new influenza antiviral drugs, viral hemorrhagic septicemia virus of fish, and Ebola virus in pigs and pig farmers in the Phillipines.

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  • Everett

    Regarding Rabies patient:

    I heard Dr. Despommier mention a teen who had recovered from rabies. Im not too sure if this is the case that he was walking about, but to my understanding, this is the first case of patient who had symptomatic rabies with no prior prophylaxis before the onset in symptoms. I think this protocol had been tried again with limited success (although seems to me a boy in Brazil had this same protocol and survived). For her high school graduation she was interviewed on the news, and while her gait had changed a small amount, her speech was clear, and her mental faculties appeared to be wholly intact. Absolutely amazing.

    The only reason I know this is because it happened here in Milwaukee and Childrens Hospital.

    Here are a few links:
    http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5350
    http://en.wikipedia.org/wiki/Jeanna_Giese

  • profvrr

    Thanks for the information, Everett. You are absolutely right; the
    young woman in Wisconsin is apparently the only individual to survive
    rabies without having been vaccinated. The physicians placed her in a
    coma which probably was the key to survival. Your CDC link documents
    this case well. There is also an article in the NEJM on this case:

    http://content.nejm.org/cgi/content/abstract/35

    I'm not sure if Dick was referring to this or not. However, Dr.
    Koprowski was probably referring to this case during his talk at
    Columbia in May 2005. He indicated that the woman was severely
    compromised, as I mentioned in the podcast, but apparently she has
    recovered well. I found a USA Today article which indicates that she
    had attended college.

    Others have survived rabies after having been immunized; these are
    apparently vaccine failures. Here is one reported in the NY Times:

    http://query.nytimes.com/gst/fullpage.html?sec=

    As for the person who Dick indicated had recently recovered from
    rabies, I suspect he was thinking about the fatal case in Ireland. The
    following is from the ProMed mail description:

    A woman who contracted rabies while working in an African animal
    sanctuary has become the 1st Briton to die from this virus infection
    for 4 years. The woman, from Northern Ireland, had been in a critical
    condition in the intensive care unit of Belfast's Royal Victoria
    Hospital since the condition was diagnosed in December [2008]. It is
    thought she was infected with the virus — which is invariably fatal
    if not treated immediately — after being scratched or bitten by a
    rabid dog she had been helping to look after.

    The ProMedMail link:

    http://www.promedmail.org/pls/otn/f?p=2400:1001

    This case had been discussed in the virology meeting in Saanen,
    Switzerland a few weeks ago that I attended.

    Vincent

  • Everett

    Regarding Rabies patient:

    I heard Dr. Despommier mention a teen who had recovered from rabies. Im not too sure if this is the case that he was walking about, but to my understanding, this is the first case of patient who had symptomatic rabies with no prior prophylaxis before the onset in symptoms. I think this protocol had been tried again with limited success (although seems to me a boy in Brazil had this same protocol and survived). For her high school graduation she was interviewed on the news, and while her gait had changed a small amount, her speech was clear, and her mental faculties appeared to be wholly intact. Absolutely amazing.

    The only reason I know this is because it happened here in Milwaukee and Childrens Hospital.

    Here are a few links:
    http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5350
    http://en.wikipedia.org/wiki/Jeanna_Giese

  • http://www.virology.ws profvrr

    Thanks for the information, Everett. You are absolutely right; the
    young woman in Wisconsin is apparently the only individual to survive
    rabies without having been vaccinated. The physicians placed her in a
    coma which probably was the key to survival. Your CDC link documents
    this case well. There is also an article in the NEJM on this case:

    http://content.nejm.org/cgi/content/abstract/35

    I'm not sure if Dick was referring to this or not. However, Dr.
    Koprowski was probably referring to this case during his talk at
    Columbia in May 2005. He indicated that the woman was severely
    compromised, as I mentioned in the podcast, but apparently she has
    recovered well. I found a USA Today article which indicates that she
    had attended college.

    Others have survived rabies after having been immunized; these are
    apparently vaccine failures. Here is one reported in the NY Times:

    http://query.nytimes.com/gst/fullpage.html?sec=

    As for the person who Dick indicated had recently recovered from
    rabies, I suspect he was thinking about the fatal case in Ireland. The
    following is from the ProMed mail description:

    A woman who contracted rabies while working in an African animal
    sanctuary has become the 1st Briton to die from this virus infection
    for 4 years. The woman, from Northern Ireland, had been in a critical
    condition in the intensive care unit of Belfast's Royal Victoria
    Hospital since the condition was diagnosed in December [2008]. It is
    thought she was infected with the virus — which is invariably fatal
    if not treated immediately — after being scratched or bitten by a
    rabid dog she had been helping to look after.

    The ProMedMail link:

    http://www.promedmail.org/pls/otn/f?p=2400:1001

    This case had been discussed in the virology meeting in Saanen,
    Switzerland a few weeks ago that I attended.

    Vincent