Comments on: Integration of arenavirus DNA into the cell genome

By: profvrr

profvrr — Fri, 17 Jun 2011 14:39:00 +0000

I’m not aware of that study, could you provide a link? However
arenaviruses and HIV are completely different, and the experiment has
no bearing on HIV infection.

By: brad

brad — Mon, 13 Jun 2011 09:55:00 +0000

They took a mouse infected with an arenavirus and cured it with IL-7. The media claimed “IL-7 cures HIV mouse!”…….how similar are arenoviruses to HIV? Does this experiment really provide hope that an IL-7-containing regimen could cure HIV in humans?

By: SCIENCEPODCASTERS.ORG » This Week in Virology #65: Matt’s bats

SCIENCEPODCASTERS.ORG » This Week in Virology #65: Matt’s bats — Mon, 11 Jan 2010 02:12:16 +0000

[...] Arenavirus DNA can be integrated into the cell genome [...]

By: TWiV 65: Matt’s bats

TWiV 65: Matt’s bats — Mon, 11 Jan 2010 01:53:48 +0000

[...] Arenavirus DNA can be integrated into the cell genome [...]

By: eyalmm

eyalmm — Sun, 23 Aug 2009 20:24:46 +0000

Hi all,

More studies have been published about this fascinating phenomena;

Maori, E., Tanne, E., and Sela, I., Reciprocal sequence exchange between non-retro viruses and hosts leading to the appearance of new host phenotypes. Virology, 2007. 362(2): p. 342-9.

Tanne, E., and Sela, I., Occurrence of a DNA sequence of a non-retro RNA virus in a host plant genome and its expression: evidence for recombination between viral and host RNAs. Virology, 2005. 332: p. 614-622.

By: eyalmm

eyalmm — Sun, 23 Aug 2009 13:24:46 +0000

By: profvrr

profvrr — Tue, 27 Jan 2009 19:13:23 +0000

You are correct, retrotransposon mediated insertion might not be
universal. The example in this paper was observed after laboratory
manipulation; there is no evidence for viral genomes, except for
retroviruses, in mammalian genomes. Clearly more work needs to be done
to answer these interesting questions.

By: Rashid

Rashid — Tue, 27 Jan 2009 15:41:04 +0000

Sir,Its very interesting finding that RNA viruses can integrate their virome in to human genome.The retrotranspsons are responsible for integration process.Is there any evidence of dsRNA virome integration in human genome.If we succeed in finding the genomes of RNA viruses,its really as important as HERV archive present in our genome.If they inherit in mendelian fashion,we can give the term V – linked inheritance:Virus Inheritance pattern in Human genome.

Sir,I guess there might be retrotransposon – independent integration in other dsRNA viruses,but after integration we fail to find out the virus RNA genome,as during host genome replication virus RNA genome will be replaced by the
DNA from DNA polymerases.Retrotransoson mediated RNA virome integration may not be universal.