Comments on: Tamiflu resistance of influenza H1N1 strains

By: Krieger1118

Krieger1118 — Wed, 07 Dec 2011 10:39:00 +0000

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By: aylabr

aylabr — Wed, 15 Jun 2011 03:03:00 +0000

relenza, also called zananivir, has demonstrated to be able to treat tamiflu resistant strains of influenza

By: ranjani

ranjani — Sat, 22 Jan 2011 12:01:00 +0000

i just chkd ur article…i m just curious to know….is dere chances of treatng tamiflu resistant strains???? is it by giving relenza…do reply

By: profvrr

profvrr — Tue, 07 Dec 2010 21:41:00 +0000

No, this article refers to the seasonal H1N1 strain that circulated before the emergence of swine-origin H1N1.

By: Mohamed

Mohamed — Mon, 06 Dec 2010 19:17:00 +0000

Hey

Maybe it’s been mentioned before, but is this article about the recent swine-flu H1N1?

By: profvrr

profvrr — Tue, 24 Nov 2009 00:00:24 +0000

Yes, the current vaccine will definitely protect even against a H1N1
strain resistant to Tamiflu. I'm shocked that the CDC rep didn't know
that.

By: Yoly

Yoly — Mon, 23 Nov 2009 23:16:51 +0000

Will the current vaccine protect against this mutated strain?

Called the CDC and representative couldn't answer the question even after consulting with others.

By: profvrr

profvrr — Mon, 23 Nov 2009 16:00:24 +0000

Yes, the current vaccine will definitely protect even against a H1N1
strain resistant to Tamiflu. I'm shocked that the CDC rep didn't know
that.

By: Yoly

Yoly — Mon, 23 Nov 2009 15:16:51 +0000

Will the current vaccine protect against this mutated strain?

Called the CDC and representative couldn't answer the question even after consulting with others.

By: profvrr

profvrr — Mon, 16 Nov 2009 13:19:16 +0000

Interesting question. I don't believe so. Viral resistance is a
consequence of mutation in the viral genome, and I'm not aware of any
human proteins that influence resistance to Tamiflu. I wouldn't rule
out the possibility for other viruses, though.

By: hadi

hadi — Sat, 14 Nov 2009 19:17:04 +0000

Could the human genome contribute to the viral H1N1 resistance to Tamiflu?

By: profvrr

profvrr — Mon, 02 Nov 2009 14:26:29 +0000

Tamifly doesn't completely block viral replication so there will still be an immune response to infection.

By: Donna

Donna — Mon, 02 Nov 2009 08:42:06 +0000

Does the use of antiviral medications such as Tamiflu prevent a person infected with H1N1 from producing antibodies to prevent reoccuring infection?

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By: profvrr

profvrr — Mon, 21 Sep 2009 13:15:07 +0000

In theory such passive transfer of antibodies would be protective. An
excellent example from the 1960s is how serum from a nurse who
recovered from Lassa fever was used to save Jordi Casal's life after
he acquired a laboratory infection. But this is not likely to be done
for influenza.

By: akshay

akshay — Sat, 19 Sep 2009 04:24:25 +0000

is blood transfusion of an recovered human to the resisting individual can b effective
so tht the antibodies can transfuse to it ??????????

By: CommentReader

CommentReader — Wed, 09 Sep 2009 13:27:47 +0000

I think you need to re-read the conversations. The replies clarify that the current H1N1 strain is NOT showing resistance to Tamiflu… This article was posted before the swine-origin strain emerged.

By: Jako

Jako — Fri, 04 Sep 2009 02:32:07 +0000

It's all very sad. I am from Brazil, we have a lot of people die, the government does nothing. We do not really buy Tamiflu, my sister, my brother bought the medicine at the pharmacy USA. The medicine helped, during the week my sister recovered. I personally do not believe in these conversations that Tamiflu does not help. Usli who need, then his brother was there to buy (not advertising) www.ekpharm.org

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By: profvrr

profvrr — Wed, 12 Aug 2009 15:15:18 +0000

There are many different 'vintages' of influenza H1N1 viruses. Since
1977 an H1N1 strains (“Russian flu”) has been circulating globally.
That strain was the subject of this blog post. In March 2009 a very
different strain of influenza H1N1 virus emerged, the swine-origin
strain that is causing the current pandemic.

By: Anurag

Anurag — Wed, 12 Aug 2009 14:47:06 +0000

how is H1N1 different from Swine Flu … and how is it that an article on H1N1 was published in Jan 09 whereas it was only in March 09 when the 1st cases were registered with WHO ??

By: profvrr

profvrr — Wed, 15 Jul 2009 15:35:34 +0000

Either Tamiflu or Relenza should be taken, not both. It's highly
unlikely that last year's H1N1 virus is causing the infection,
although there is still some of that virus circulating. The strains
can be differentiated from one another, but it requires sophisticated
lab tests which cannot be done in a doctor's office. Tamiflu should
lead to improvement within a few days.

By: siam_spearo

siam_spearo — Tue, 14 Jul 2009 13:20:59 +0000

Dear Profvrr,

I am not a Doctor or a specialist in medicine. I am living in Thailand and the doctors here are less educated than those on the front line, they tend to copy the trends and go with second opinions from the states, europe and WHO.
It is very confussing for me as these opinions seem to change as quickly as the Virus does.
My Partner tested positive to type A and negative to type B, we have been told that this means there is a chance that she may have H1N1, I am now online a few hours later after putting her in bed looking for help on the internet as the academics of Thailand seem to have little to no help for us.
She has been given TAMIFLU 75MG (Oseltamivir) BISOLVEN 8MG (Bromhexine Hydrochloride) ROTUSS CAPSULE and CLARINASE (5MG LORATADINE & 120MG PSEUDOEPHEDRINE SULFATE)

From what little I have learnt on the net this evening it looks as though she should be taking Tamiflu and Relenza and not either or, could you confirm this for me? I noticed your most recent post mentioning the previous strains resistance to Tamiflue, is it possible that we are suffering from the same strain of tamiflu resistant H1N1 and is there anyway to tell the seperate strains from one another?
We have been told that she will be better in 5 days of treatment and that there is nothing to worry about but after living here for a decade I know that this is just another way of saying they don't know what will happen.
I'm sorry to trouble you but i Love her very very much I hope to hear from you soonest.

Regards,
Craig

By: Tom

Tom — Fri, 19 Jun 2009 19:37:48 +0000

Thanks!

By: profvrr

profvrr — Fri, 19 Jun 2009 14:39:20 +0000

The H1N1 influenza virus strain of the past season was highly
resistant to Tamiflu. The 2009 pandemic H1N1 strain, however, is
susceptible to the antiviral drug. The blog post you are reading here
concerns the previous season's H1N1 strain; it was written before the
new H1N1 strain emerged.

By: Tom

Tom — Fri, 19 Jun 2009 14:02:01 +0000

A popular health website (www.everydayhealth.com) provides the following Q&A:

"Should I take Tamiflu or Relenza to prevent swine flu?
According to the CDC, Tamiflu and Relenza can be used to prevent influenza in a person who is not ill but who has been or may be near a person with swine influenza. These antiviral drugs are 70 to 90 percent effective, and the dosage depends on an individual's particular situation. The average person does not need to take either Tamiflu or Relenza at this time, and it is likely that pharmacists will not fill prescriptions unless you already have confirmed swine influenza."
If most North American H1N1 is highly resistant to Tamiflu, presumably this advice is dead wrong; or am I missing something? Thanks

Tom

By: Kumar

Kumar — Sun, 14 Jun 2009 02:57:07 +0000

Is the current h1n1 epidemic could again rise the tamiflu resistance?

By: DSS

DSS — Sat, 09 May 2009 15:13:56 +0000

Finally, an educated san opinion
Congratulations

Dr D S S

By: robert

robert — Mon, 04 May 2009 11:37:16 +0000

Swine flu is man made…follow the money

By: robert

robert — Mon, 04 May 2009 11:37:16 +0000

Swine flu is man made…follow the money

By: Matt

Matt — Mon, 04 May 2009 09:40:11 +0000

Aggravating our susceptibility to becoming ill, there is the stress in our society due to an almost unique confluence of record unemployment, insolvency, bankruptcy with war and pandemics— Not to mention the general lack of affordability in health-care

By: drC

drC — Sun, 26 Apr 2009 23:25:02 +0000

the anti-virals we currently have demonstrate 8-10% rate of mutation at baseline, greater percentages in the pediatric population for some reason. Anyway, using these meds on a population scale response to influenza is irresponsible at least and criminal at worst.

By: american dream

american dream — Wed, 11 Mar 2009 12:15:42 +0000

Raivo Pommer
raimo1@hot.ee

HEDGE-FOND

Die Kapitalabflüsse gestalteten sich in der Branche in Europa und den Vereinigten Staaten allerdings sehr unterschiedlich: Während amerikanische Hedge-Fonds in großem Umfang juristische Sperren nutzten, die eine sofortige Rückzahlung von Anlagegeld an die Kunden beschränkten oder hinauszögerten (Gates), ist dies bei europäischen Hedge-Fonds weniger üblich. Auch gibt es in Europa mehr Dachfonds, in die Privatinvestoren investieren. Diese hatten die erste Kündigungswelle bei Hedge-Fonds im Herbst 2008 ausgelöst. Die Kapitalabflüsse aus Hedge-Fonds waren daher in der zweiten Jahreshälfte vor allem in Europa relativ hoch. Die Mittel europäischer Hedge-Fonds schrumpften nach Einschätzung von Morgan Stanley um 25 bis 30 Prozent.

In den Vereinigten Staaten beliefen sich die Mittelabflüsse zunächst „nur“ auf 15 bis 20 Prozent. Dies erklärt, warum der weltweite Verband der Hedge-Fonds, die Alternative Investment Management Association (AIMA), kürzlich bekanntgab, dass das Anlagekapital der 1200 bei der AIMA registrierten Mitglieder jetzt zum Großteil von institutionellen Investoren gehalten werde und nicht mehr von vermögenden Einzelpersonen, wie dies früher der Fall gewesen war.

By: pum

pum — Thu, 05 Mar 2009 18:52:19 +0000

Raivo Pommer
raimo1@hot.ee

Gegen krise

Die norddeutschen Länder wollen gemeinsam beim Bund für ihre Verkehrsprojekte kämpfen. Hamburgs Bürgermeister Ole von Beust (CDU) sagte heute nach einem Treffen mit den Regierungschefs von Schleswig-Holstein, Niedersachsen, Bremen und Mecklenburg-Vorpommern, Berlin müsse sich der Hinterlandanbindung der Häfen und der Infrastruktur mehr widmen: "Wichtig ist uns, dass der Bund verstärkt einsteigt." Aus dem Konjunkturprogramm I sei nicht genug angekommen. "Da geht es darum, das aufzustocken." Bremens Bürgermeister Jens Böhrnsen (SPD) betonte: "Dazu gehört auch, dass wir (...) deutlich machen, dass der Anteil des Bundes an Hafeninvestitionen und vor allem auch an der Hafenunterhaltung viel zu gering ist."

By: money prof

money prof — Wed, 04 Mar 2009 16:44:15 +0000

Raivo Pommer
raimo1@hot.ee

Depfa Bank Krise

Es handelt sich dabei um eine nachrangige Anleihe über 500 Millionen Euro. Die für den 21. März geplante Zinszahlung falle nach einem Beschluss des Verwaltungsrats der Depfa aus.

Eine Entscheidung zu ähnlichen Papieren der Depfa stehe noch aus. "Diese Nachricht könnte das Vertrauen in das Marktsegment erschüttern", kommentierten Anleihenhändler.

"Das ist ein politisches Debakel", sagte Bankenprofessor Klaus Fleischer von der Fachhochschule München. Schließlich seien die Garantien und Hilfen des staatlichen Rettungsfonds Soffin in Höhe von mehr als 102 Milliarden Euro in die HRE-Gruppe geflossen, "um Schaden vom Kapitalmarkt abzuwenden".

Nach Angaben der HRE hat die Bankengruppe vier Nachranganleihen im Volumen von insgesamt 1,55 Milliarden Euro ausstehen. Zinstermine sind im März, im Juni und im Oktober. Der Analysedienst Dealogic gibt den Gesamtmarkt vergleichbarer Nachranganleihen in Europa mit 300 Milliarden Euro an.

By: profvrr

profvrr — Mon, 19 Jan 2009 12:47:15 +0000

You are right. The combination of RNA virus + just a few antiviral
compounds = guaranteed resistance. But I understand that new flu
antivirals are being tested, so that perhaps in the future we will use
combinations as is done for HIV.

By: Jonathon Singleton

Jonathon Singleton — Fri, 16 Jan 2009 00:18:24 +0000

’Spontaneous’ — perhaps an evolutionary paradigm consistent with the flawed science of genetically modified crops and organisms using unstable viral promoters!?! Horizontal gene transfer and recombination working at an accelerated pace — not unlike the premise of a science fiction disaster novel, where corporate greed and nu science in its longitudinal tested infancy is thrown out into the commercial world and… Hey cliche, a few years later we have what we are now experiencing re: Tamiflu resistance at 100% in H1N1 which may cross over into other H/N viruses shortly!?! Just a thought — I've been researching this area for nine years…

By: profvrr

profvrr — Tue, 13 Jan 2009 19:08:47 +0000

I'm not aware of any such HIV-resistant prostitutes. The road to
Kinshasha has a huge death rate because over 90% of the prostitutes
who work there are infected. But I will ask Jeremy Luban who is
joining me in the next TWiV this week.

The HERVs in humans are retroviruses, not lentiviruses and thus would
not be expected to interfere with HIV replication.

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Tue, 13 Jan 2009 16:21:16 +0000

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By: ET

ET — Mon, 12 Jan 2009 20:22:28 +0000

To switch topics if I may;

frequently there is reference to women 'along the road to Kinshasha' who, despite being exposed to HIV presumably repeatedly since the beginning of the epidemic, have no trace of the virus. I suppose my first question is a) are their such women (who seem to have achieved a folklore-like status), and b) if they have no trace what so ever of the virus, then are they controlling it in a way different from the elite controllers?

And finally, Is it possible that HERV's play a role here? These are records of our previous battles with retroviruses are they not? So then, by default, does that mean that there must be some segment of the population that is completely immune to this disease somewhere?

By: profvrr

profvrr — Mon, 12 Jan 2009 11:08:26 +0000

In theory, yes…but individual glycoproteins are not always as immunogenic as the whole virion. As you know, there is an effective vaccine for influenza which consists of whole, inactivated virions (or in some cases whole virions which are then disrupted with detergent). These vaccines are immunogenic and protective. Glycoprotein vaccines against influenza have been tested but are far less effective than the current vaccines. Which is not to say the situation will not improve with futher research.

By: ET

ET — Sun, 11 Jan 2009 21:10:50 +0000

If the technique for an HIV vaccine is to find a glycoprotein that is always present, then is it not possible to do the same with Influenza?

By: profvrr

profvrr — Sat, 10 Jan 2009 20:17:40 +0000

Because of the central nervous system side effects of amantadine is less frequently used to treat influenza. Rimantadine has fewer side effects. I suspect the H1N1 strains are susceptible to amantadine as it is very similar to rimantadine. In recent years the CDC has recommended the use of amantadine, but this year, the recommendation is zanamivir or a combination of oseltamivir and rimantadine.

By: ET

ET — Sat, 10 Jan 2009 12:27:10 +0000

Is amantadine ( the original one I mean) still used as an antiviral, and is it efficacious against influenza?