By David Tuller, DrPH

This month is the start of the second half of my one-year crowdfunding commitment to keep reporting on ME/CFS, so I figured I should review what I’ve done so far, what I still hope to do, and what changes have taken place during the last six months. So, here goes.

[click to continue…]

TWiV 476: In ACOD1 we trust

Nels joins the TWiV team to talk about his work on genomic accordions in vaccinia virus, hepatitis B virus in a 439 year old mummy, and viral induction of energy synthesis by a long noncoding RNA.

Click arrow to play
Download TWiV 476 (63 MB .mp3, 105 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

HBV mummy

Vesicopustular rash on face (C) and arm (D) of 439 year old mummy. Image credit.

A study done in 1985 on a 16th century Italian mummy suggested that the two year old child had smallpox. Recent sequence analysis of tissues from the mummy now reveal the presence of hepatitis B virus, not smallpox virus. The sequence of the viral genome suggests that HBV entered the human population well before 1500.

[click to continue…]

In the first episode for 2018, the TWiV team reviews the amazing virology stories of 2017.

Click arrow to play
Download TWiV 475 (67 MB .mp3, 110 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

By David Tuller, DrPH

Yesterday I reviewed an account of a publishing dilemma that had been submitted to the forum of the Committee on Publication Ethics. The COPE forum offers advice on thorny situations submitted anonymously by members. In this case, the submission appeared to be from BMJ Open and it appeared to be discussing Professor Esther Crawley’s school absence study. That study was exempted from ethical review on the specious grounds that it qualified as “service evaluation.” BMJ Open has defended its decision to publish the paper without ethical review.

[click to continue…]

By David Tuller, DrPH

This post is about a serious issue–ethical approval for research studies involving children. It is also about how powerful institutions, like leading medical journals, respond to concerns. But the story is really too long and complicated. I recommend it only for those following things pretty closely or who for whatever reason like this kind of granular, somewhat obsessive analysis.

[click to continue…]

TWiV 474: Call me fish meal

The TWiVanguardians take on Bodo saltans virus, a leviathan which infects an abundant flagellated eukaryote in Earth’s waters.

Click arrow to play
Download TWiV 474 (62 MB .mp3, 103 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv

Bodo saltans

Bodo saltans

The discovery of Mimivirus in a French cooling tower amazed virologists and changed our view of the biology and evolution of giant viruses. Since then, many other giant viruses have been identified, and with three exceptions, they all appear to infect species of Acanthamoeba. Now a new member of the Mimivirus family has been discovered that infects the flagellated eukaryote Bodo saltans (pictured: image credit).

[click to continue…]

By David Tuller, DrPH

I wanted to post something this week, but not a whole long thing. So I thought I’d just post the top of what I’ll post in full next week.

This week ends the first half–six months!–of my crowdfunded project. Sometime soon I’ll post something or other looking backward and forward a bit. But not today.

**********

[click to continue…]

The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors.

Click arrow to play
Download TWiV 473 (67 MB .mp3, 110 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Show notes at microbe.tv/twiv