Virology
Does Herpes Simplex Virus Cause Alzheimer’s Disease?
By Gertrud U. Rey | | Basic virology, Gertrud Rey
by Gertrud U. Rey Alzheimer’s Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Although its exact cause is unclear, an increasing body of evidence suggests that an infection with herpes simplex virus (HSV) may contribute to onset of AD later in life. Both types of HSV (HSV-1 and HSV-2) infect …
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Dogma Does Not Belong in Science
By Gertrud U. Rey | | Basic virology, Gertrud Rey
by Gertrud U. Rey According to established scientific dogma, infection of cells with HIV-1 leads to delivery of the viral capsid into the cell cytoplasm, followed by “uncoating” of the capsid to release the single-stranded RNA genome. A viral-encoded enzyme called reverse transcriptase then catalyzes the conversion of the viral RNA into a single strand …
Let’s Talk About Measles
By Gertrud U. Rey | | Basic virology, Gertrud Rey
by Gertrud U. Rey Recent news headlines have been featuring multiple outbreaks of measles across the globe, and an announcement from the Centers for Disease Control and Prevention dated January 25, 2024, also reported 23 confirmed cases in the US over the past month. These outbreaks happen every few years and are usually triggered by …
The Problem of Original Antigenic Sin
By Gertrud U. Rey | | Basic virology, Gertrud Rey
by Gertrud U. Rey Once the innate immune system senses a never-seen-before pathogen as new, it engages elements of the adaptive immune response. These adaptive immunity elements coordinate over time to develop a response that protects from re-infection and disease upon a second exposure to the same pathogen. The second exposure will immediately lead to …
A Satellite Takes a Bite of Phage
By Gertrud U. Rey | | Basic virology, Gertrud Rey
by Gertrud U. Rey Satellite viruses lack one or more of the elements needed to replicate, and thus they depend on co-infection with a helper virus that can provide the missing components. In a well-known example of a satellite-helper system, Hepatitis D virus requires the presence of its helper Hepatitis B virus to make copies …
A Nobel Discovery
By Gertrud U. Rey | | Basic virology, Gertrud Rey
by Gertrud U. Rey On October 2nd, 2023, the Nobel Assembly at Karolinska Institutet announced the award of the 2023 Nobel Prize in Physiology or Medicine to Katalin Karikó and Drew Weissman. The decision was based on a series of fundamental discoveries that led to the development of the COVID-19 messenger RNA (mRNA) vaccines. Katalin …
David Tuller
Trial By Error: Australian GP Group Recommends “Incremental Physical Activity” for “CFS/ME” Patients
By David Tuller, DrPH What’s going on with Aussie members of the graded exercise therapy cult? (Oops!—I meant the Royal Australian College of General Practitioners, a trade and professional organization. Sorry!) In 2019, I wrote about the organization’s guidance for “CFS/ME.” This guidance, published in 2015, was part of the group’s Handbook of Non-Drug Interventions …
Trial By Error: Guardian Columnist George Monbiot Discusses His Scathing Rebuke of the Biopsychosocial Brigades–Text Version
By David Tuller, DrPH Last week, I spoke with George Monbiot, a British investigative reporter and political activist, who has been a columnist for The Guardian for almost 30 years. He and I have been in occasional communication in recent years over an issue of mutual interest—the scandalous mistreatment of patients suffering from the devastating illness (or cluster …
Trial By Error: Guardian Columnist George Monbiot Discusses His Scathing Critique of the “Biopsychosocial” Approach to ME/CFS and Long Covid
By David Tuller, DrPH Earlier today I spoke with George Monbiot, a British investigative reporter and political activist, who has been a columnist for The Guardian for almost 30 years. He and I have been in occasional communication in recent years over an issue of mutual interest—the scandalous mistreatment of patients suffering from the devastating …
Trial By Error: Senator Bernie Sanders’ $10 Billion Long Covid “Moonshot” Proposal
By David Tuller, DrPH On April 9th, Senator Bernie Sanders, the independent senator from Vermont who votes with the Democrats, unveiled an ambitious $10 billion “moonshot” proposal to fund research into Long Covid. The proposal has raised hopes among patients with the disease or cluster of diseases now being called ME/CFS—as well as concerns that …
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Trial By Error: An Interview with the Authors of the European ME Alliance Survey of 11,000+ Patients
By David Tuller, DrPH Earlier this month, the European Myalgic Encephalomyelitis Alliance (EMEA) released a 235-page report on a survey of ME/CFS patients in Europe titled “Same disease, different approaches and experiences.” The authors are Arild Angelsen, a board member of the Norwegian ME Association and a professor at the School of Economics and Business …
Trial By Error: REGAIN Team Responds to Criticism with Unconvincing Defenses of Methodological Missteps
By David Tuller, DrPH In recent weeks, I have been urging The BMJ to correct a flawed University of Warwick trial of an online mental and physical health rehab program for people with prolonged symptoms at least three months after hospitalization for Covid-19. The primary outcome was health-related quality of life, assessed with a measure …